Riding the metal wave: A review of the latest developments in metal-based anticancer agents

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 501, P. 215579 - 215579

Published: Nov. 28, 2023

Language: Английский

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Multimetallic transition metal complexes:Luminescent probes for biomolecule sensing, ion detection, imaging and therapeutic application

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 504, P. 215656 - 215656

Published: Jan. 19, 2024

Language: Английский

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Synthesis of TiO2 nanoparticles using different routes with enhanced photocatalytic and antibacterial properties

Ceramics International, Journal Year: 2024, Volume and Issue: 50(9), P. 15780 - 15789

Published: Feb. 5, 2024

Language: Английский

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Recent advances and clinical challenges of phototherapeutic nanoparticles in cancer monotherapy or combination therapy

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 518, P. 216069 - 216069

Published: July 15, 2024

Language: Английский

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Metal-based nanoparticles in cancer therapy: Exploring photodynamic therapy and its interplay with regulated cell death pathways

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 649, P. 123622 - 123622

Published: Nov. 19, 2023

Photodynamic therapy (PDT) represents a non-invasive treatment strategy currently utilized in the clinical management of selected cancers and infections. This technique is predicated on administration photosensitizer (PS) subsequent irradiation with light specific wavelengths, thereby generating reactive oxygen species (ROS) within targeted cells. The cellular effects PDT are dependent both localization PS severity ROS challenge, potentially leading to stimulation various cell death modalities. For many years, concept regulated (RCD) triggered by photodynamic reactions predominantly encompassed apoptosis, necrosis, autophagy. However, recent decades, further explorations have unveiled additional modalities, such as necroptosis, ferroptosis, cuproptosis, pyroptosis, parthanatos, immunogenic (ICD), which helps achieve tumor elimination. Recently, nanoparticles (NPs) demonstrated substantial advantages over traditional PSs become important components PDT, due their improved physicochemical properties, enhanced solubility superior specificity for review aims summarize advancements applications different metal-based NPs or delivery systems optimized cancer treatment. Furthermore, it mechanistically highlights contribution RCD pathways during metal how these forms can improve regimens therapy.

Language: Английский

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Ruthenium (II) polypyridyl complexes as two-photon absorbers and sensitizers: Design, structure-properties relationships and applications

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 518, P. 216050 - 216050

Published: July 7, 2024

This review addresses recent advancements in understanding multiphoton excitation of ruthenium polypyridyl complexes, highlighting their relevance the fields molecular materials and bio-medical applications. Emphasis is placed on two-photon absorption excited photoluminescence for which these complexes meet several requirements as sensitizers. Alongside appealing one-photon properties, are photostable under can exhibit noticeable cross-sections near-infrared (NIR) region. Moreover, presence atom favors spin–orbit coupling, facilitating rapid efficient population triplet states, thereby extending emission lifetimes, or uncaging reactions, according to structural characteristics. Indeed, offer great versatility terms functionalization, enabling property fine-tuning. also outlines forthcoming challenges prospects field through representative examples area materials, bio-imaging phototherapies.

Language: Английский

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Recent Advances in Photodynamic Therapy: Metal-Based Nanoparticles as Tools to Improve Cancer Therapy

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(7), P. 932 - 932

Published: July 12, 2024

Cancer remains a significant global health challenge, with traditional therapies like surgery, chemotherapy, and radiation often accompanied by systemic toxicity damage to healthy tissues. Despite progress in treatment, these approaches have limitations such as non-specific targeting, toxicity, resistance development cancer cells. In recent years, nanotechnology has emerged revolutionary frontier therapy, offering potential solutions challenges. Nanoparticles, due their unique physical chemical properties, can carry therapeutic payloads, navigate biological barriers, selectively target Metal-based nanoparticles, particular, offer properties suitable for various applications. Recent advancements focused on the integration of metal-based nanoparticles enhance efficacy precision photodynamic therapy. Integrating into therapy represents paradigm shift, enabling strategies enhanced specificity reduced off-target effects. This review aims provide comprehensive understanding pivotal role We explore mechanisms, biocompatibility, applications highlighting challenges use, well combining nanoparticles/photodynamic other synergistic approach treatment.

Language: Английский

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Leveraging the Photofunctions of Transition Metal Complexes for the Design of Innovative Phototherapeutics

Small Methods, Journal Year: 2024, Volume and Issue: 8(11)

Published: Sept. 25, 2024

Abstract Despite the advent of various medical interventions for cancer treatment, disease continues to pose a formidable global health challenge, necessitating development new therapeutic approaches more effective treatment outcomes. Photodynamic therapy (PDT), which utilizes light activate photosensitizer produce cytotoxic reactive oxygen species (ROS) eradicating cells, has emerged as promising approach due its high spatiotemporal precision and minimal invasiveness. However, widespread clinical use PDT faces several challenges, including inefficient production ROS in hypoxic tumor microenvironment, limited penetration depth biological tissues, inadequate accumulation photosensitizers at site. Over past decade, there been increasing interest utilization photofunctional transition metal complexes applications their intriguing photophysical photochemical properties. This review provides an overview current design strategies used innovative phototherapeutics, aiming address limitations associated with achieve The challenges future perspectives on translation are also discussed.

Language: Английский

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Synthesis and Characterization of a Hercynite-Supported Copper(II) Complex Based on 1,10-Phenanthroline-5,6-dione and Acetylacetone Building Blocks and Its Catalytic Application in Annulation Reactions

Langmuir, Journal Year: 2024, Volume and Issue: 40(43), P. 22773 - 22786

Published: Oct. 18, 2024

In the present work, a novel Cu(II) complex containing 10-phenanthroline-5,6-dione (phen-dione) and acetylacetone (acac) was prepared via solid-phase synthesis on silica-modified hercynite magnetic nanoparticles (MNPs). The resulting structure underwent thorough structural analysis using diverse instrumental techniques. catalytic potential of synthesized successfully demonstrated in 2-amino-3-cyano-4

Language: Английский

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Luminescent lanthanide-based molecular materials: applications in photodynamic therapy

Dalton Transactions, Journal Year: 2024, Volume and Issue: 53(5), P. 1898 - 1914

Published: Jan. 1, 2024

This review focuses on the latest developments in luminescent lanthanide-based molecular materials as photosensitizers and their applications photodynamic therapy.

Language: Английский

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