Layered double hydroxide-based nanomaterials for biomedical applications

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(14), P. 6126 - 6176

Published: Jan. 1, 2022

Against the backdrop of increased public health awareness, inorganic nanomaterials have been widely explored as promising nanoagents for various kinds biomedical applications. Layered double hydroxides (LDHs), with versatile physicochemical advantages including excellent biocompatibility, pH-sensitive biodegradability, highly tunable chemical composition and structure, ease composite formation other materials, shown great promise in In this review, we comprehensively summarize recent advances LDH-based Firstly, material categories are discussed. The preparation surface modification nanomaterials, pristine LDHs, nanocomposites LDH-derived then described. Thereafter, systematically describe potential LDHs applications drug/gene delivery, bioimaging diagnosis, cancer therapy, biosensing, tissue engineering, anti-bacteria. Finally, on basis current state art, conclude insights remaining challenges future prospects rapidly emerging field.

Language: Английский

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A MgFe‐LDH Nanosheet‐Incorporated Smart Thermo‐Responsive Hydrogel with Controllable Growth Factor Releasing Capability for Bone Regeneration

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(5)

Published: Nov. 25, 2022

Although growth factor (GF)-loaded hydrogels have been explored as promising materials in repairing bone defects, it still remains challenging to construct smart with excellent gelation/mechanical properties well controllable GF releasing capability. Herein, the incorporation of morphogenetic protein 2 (BMP-2)-functionalized MgFe-layered double hydroxide (LDH) nanosheets into chitosan/silk fibroin (CS) loaded platelet-derived factor-BB (PDGF-BB) a injectable thermo-responsive hydrogel (denoted CSP-LB), which can achieve burst release PDGF-BB and sustained BMP-2, for highly efficient regeneration is reported. The MgFe-LDH CS not only shortens gelation time decreases sol-gel transition temperature, but also enhances mechanical property hydrogel. Because sequential dual-GFs bioactive Mg2+ /Fe3+ ions, vitro experiments prove that CSP-LB exhibits angiogenic osteogenic compared In vivo further significantly enhance higher volume mineral density than This thermo-sensitive possesses capability properties, thus providing minimally invasive solution defect treatment.

Language: Английский

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Microenvironment-responsive nanocarriers for targeted bone disease therapy

Nano Today, Journal Year: 2023, Volume and Issue: 50, P. 101838 - 101838

Published: March 29, 2023

Language: Английский

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Synthetic biology‐based bacterial extracellular vesicles displaying BMP‐2 and CXCR4 to ameliorate osteoporosis

Journal of Extracellular Vesicles, Journal Year: 2024, Volume and Issue: 13(4)

Published: April 1, 2024

Osteoporosis (OP) is a systematic bone disease characterized by low mass and fragile microarchitecture. Conventional treatment for OP has limited efficacy long-term toxicity. Synthetic biology makes bacterial extracellular vesicle (BEVs)-based therapeutic strategies promising alternative the of OP. Here, we constructed recombinant probiotics Escherichia coli Nissle 1917-pET28a-ClyA-BMP-2-CXCR4 (ECN-pClyA-BMP-2-CXCR4), in which BMP-2 CXCR4 were overexpressed fusion with BEVs surface protein ClyA. Subsequently, isolated engineered BEVs-BMP-2-CXCR4 (BEVs-BC) therapy. The BEVs-BC exhibited great targeting vivo. In addition, had good biocompatibility remarkable ability to promote osteogenic differentiation BMSCs. Finally, synthetic biology-based significantly prevented an ovariectomized (OVX) mouse model. conclusion, both bone-targeting bone-forming one-step using biology, provides effective strategy potential industrialization.

Language: Английский

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Layered Double Hydroxides: Recent Progress and Promising Perspectives Toward Biomedical Applications

Advanced Science, Journal Year: 2024, Volume and Issue: 11(20)

Published: March 19, 2024

Abstract Layered double hydroxides (LDHs) have been widely studied for biomedical applications due to their excellent properties, such as good biocompatibility, degradability, interlayer ion exchangeability, high loading capacity, pH‐responsive release, and large specific surface area. Furthermore, the flexibility in structural composition ease of modification LDHs makes it possible develop specifically functionalized meet needs different applications. In this review, recent advances applications, which include LDH‐based drug delivery systems, cancer diagnosis therapy, tissue engineering, coatings, functional membranes, biosensors, are comprehensively discussed. From these various research fields, can be seen that there is great potential possibility use However, at same time, must recognized actual clinical translation still very limited. Therefore, current limitations related on discussed by combining limited examples with requirements biomaterials. Finally, an outlook future provided.

Language: Английский

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Doping Engineering of Piezo‐Sonocatalytic Nanocoating Confer Dental Implants with Enhanced Antibacterial Performances and Osteogenic Activity

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(21)

Published: Jan. 30, 2024

Abstract Rescuing dental implants from plaque‐induced infection and implementing effective plaque control methods in a limited oral environment pose challenges for modern dentistry. To address this issue, Al ion doped strontium titanate/titanium dioxide nanotubes (Al‐SrTiO 3 /TiO 2 nanotubes, Al‐STNT) are designed as an ultrasound‐responsive nanocoating immobilized on the Ti implant surface. Introducing 3+ ions into inorganic sonosensitive SrTiO heterojunction induces oxygen vacancies disrupts lattice of . By overcoming bandgap barrier through ultrasonic stimulated piezoelectric effect, Al‐STNT produces more reactive species (ROS). In sonodynamic therapy (SDT) process, stimulus abundant ROS efficiently disrupting bacteria biofilm inhibiting metabolism. Moreover, specific nanoscale coating endows with osteogenic activity, facilitating formation rigid osseointegration between surface alveolar bone. mimicking human rats, demonstrates optimal postimplant while retaining its antibacterial ability sonosensitizer. Thanks to portability ultrasound instrument stability implant‐based sonosensitizer, strategy presents attractive option patients self‐treat secure long‐term success their implants.

Language: Английский

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Biomaterial design for regenerating aged bone: materiobiological advances and paradigmatic shifts

National Science Review, Journal Year: 2024, Volume and Issue: 11(5)

Published: Feb. 27, 2024

China's aging demographic poses a challenge for treating prevalent bone diseases impacting life quality. As regeneration capacity diminishes with age due to cellular dysfunction and inflammation, advanced biomaterials-based approaches offer hope aged regeneration. This review synthesizes materiobiology principles, focusing on biomaterials that target specific biological functions restore tissue integrity. It covers strategies stem cell manipulation, regulation of the inflammatory microenvironment, blood vessel regeneration, intervention in anabolism catabolism, nerve regulation. The also explores molecular mechanisms underlying proposes database-driven design process future biomaterial development. These insights may guide therapies other age-related conditions, contributing pursuit 'healthy aging'.

Language: Английский

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Surface Functionalization of Hydroxyapatite Scaffolds with MgAlEu‐LDH Nanosheets for High‐Performance Bone Regeneration

Advanced Science, Journal Year: 2022, Volume and Issue: 10(1)

Published: Nov. 17, 2022

Although artificial bone repair scaffolds, such as titanium alloy, bioactive glass, and hydroxyapatite (HAp), have been widely used for treatment of large-size defects or serious destruction, they normally exhibit unsatisfied efficiency because their weak osteogenic angiogenesis performance well poor cell crawling adhesion properties. Herein, the surface functionalization MgAlEu-layered double hydroxide (MAE-LDH) nanosheets on porous HAp scaffolds is reported a simple effective strategy to prepare HAp/MAE-LDH enhanced regeneration. The MAE-LDHs scaffold can significantly improve its roughness, specific surface, hydrophilicity, thus effectively boosting cells differentiation. Importantly, grown enable sustained release Mg

Language: Английский

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Engineered bacterial extracellular vesicles for osteoporosis therapy

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 450, P. 138309 - 138309

Published: July 30, 2022

Osteoporosis (OP) is a systemic bone disease characterized by reduction of mass and destruction structure, which can easily lead to fragility fractures. Over the past decade, an expanding body study suggests that gut microbiota (GM) plays important role in homeostasis pathogenesis OP. The communication mechanism between GM OP has received increasing attention. Bacterial extracellular vesicles (BEVs) are irreproducible phospholipid bilayer nanocarriers with sizes ranging from 20 400 nm, mediate delivering various bioactive molecules. BEVs have emerged as promising platform for treatment due their nanosized structures, low toxicity, drug loading capacity, good biocompatibility, ease modification industrialization. Here, we summarize overview BEVs, including biogenies, classes, compositions, internalization, isolation BEVs. We then focus on applications natural Subsequently, present two major engineering strategies, parental strain after isolation, modifying treatment. Finally, provide outlook challenges future prospects hope comprehensive understanding engineered will new solutions

Language: Английский

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Composite Nanocoatings of Biomedical Magnesium Alloy Implants: Advantages, Mechanisms, and Design Strategies

Advanced Science, Journal Year: 2023, Volume and Issue: 10(18)

Published: April 25, 2023

The rapid degradation of magnesium (Mg) alloy implants erodes mechanical performance and interfacial bioactivity, thereby limiting their clinical utility. Surface modification is among the solutions to improve corrosion resistance bioefficacy Mg alloys. Novel composite coatings that incorporate nanostructures create new opportunities for expanded use. Particle size dominance impermeability may increase prolong implant service time. Nanoparticles with specific biological effects be released into peri-implant microenvironment during promote healing. Composite nanocoatings provide nanoscale surfaces cell adhesion proliferation. activate cellular signaling pathways, while those porous or core-shell structures carry antibacterial immunomodulatory drugs. vascular reendothelialization osteogenesis, attenuate inflammation, inhibit bacterial growth, thus increasing applicability in complex microenvironments such as atherosclerosis open fractures. This review combines physicochemical properties efficiency Mg-based biomedical summarize advantages nanocoatings, analyzes mechanisms action, proposes design construction strategies, purpose providing a reference promoting application further nanocoatings.

Language: Английский

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