Nanozyme‐Enhanced Electrochemical Biosensors: Mechanisms and Applications

Small, Journal Year: 2023, Volume and Issue: 20(14)

Published: Nov. 20, 2023

Abstract Nanozymes, as innovative materials, have demonstrated remarkable potential in the field of electrochemical biosensors. This article provides an overview mechanisms and extensive practical applications nanozymes First, definition characteristics are introduced, emphasizing their significant role constructing efficient sensors. Subsequently, several common categories nanozyme materials delved into, including metal‐based, carbon‐based, metal‐organic framework, layered double hydroxide nanostructures, discussing Regarding mechanisms, two key roles particularly focused biosensors: selective enhancement signal amplification, which crucially support sensor performance. In terms applications, widespread use nanozyme‐based biosensors showcased various domains. From detecting biomolecules, pollutants, nucleic acids, proteins, to cells, providing robust means for high‐sensitivity detection. Furthermore, insights into future development is provided, encompassing improvements optimizations design integration, expansion application fields through interdisciplinary collaboration. conclusion, this systematically presents biosensors, offering valuable references prospects research field.

Language: Английский

---

Solubilization techniques used for poorly water-soluble drugs

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(11), P. 4683 - 4716

Published: Sept. 2, 2024

About 40% of approved drugs and nearly 90% drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving bioavailability is a critical issue that needs to be urgently addressed in development application. This review briefly introduces conventional solubilization techniques such as solubilizers, hydrotropes, cosolvents, prodrugs, salt modification, micronization, cyclodextrin inclusion, solid dispersions, details crystallization strategies, ionic liquids, polymer-based, lipid-based, inorganic-based carriers bioavailability. Some most commonly used carrier materials for presented. Several using summarized. Furthermore, this summarizes mechanism each technique, reviews latest research advances challenges, evaluates potential clinical translation. could guide selection approach, dosage form, administration route Moreover, we discuss several promising attracting increasing attention worldwide.

Language: Английский

---

An Injectable Thermosensitive Hydrogel Containing Resveratrol and Dexamethasone‐Loaded Carbonated Hydroxyapatite Microspheres for the Regeneration of Osteoporotic Bone Defects

Small Methods, Journal Year: 2023, Volume and Issue: 8(1)

Published: Oct. 6, 2023

Abstract Bone defects in osteoporosis usually present excessive reactive oxygen species (ROS), abnormal inflammation levels, irregular shapes and impaired bone regeneration ability; therefore, osteoporotic are difficult to repair. In this study, an injectable thermosensitive hydrogel poly (D, L‐lactide)‐poly (ethylene glycol)‐ L‐lactide) (PLEL) system containing resveratrol (Res) dexamethasone (DEX) is designed create a microenvironment conducive osteogenesis defects. This PLEL injected filled defect areas achieving rapid sol‐gel transition situ. Res has strong anti‐inflammatory effects that can effectively remove excess free radicals at the damaged site, guide macrophage polarization M2 phenotype, regulate immune responses. Additionally, DEX promote osteogenic differentiation. vitro experiments showed promoted differentiation of mesenchymal stem cells, removed intracellular ROS, regulated reduce inflammatory vivo modulated Overall, study confirmed treat by synergistically modulating damage microenvironment, alleviating responses, promoting osteogenesis; thus, it represents promising drug delivery strategy repair

Language: Английский

---

Layered Double Hydroxides: A Novel Promising 2D Nanomaterial for Bone Diseases Treatment

Advanced Science, Journal Year: 2023, Volume and Issue: 10(24)

Published: June 17, 2023

Bone diseases including bone defects, infections, osteoarthritis, and tumors seriously affect life quality of the patient bring serious economic burdens to social health management, for which current clinical treatments bear dissatisfactory therapeutic effects. Biomaterial-based strategies have been widely applied in treatment orthopedic but are still plagued by deficient bioreactivity. With development nanotechnology, layered double hydroxides (LDHs) with adjustable metal ion composition alterable interlayer structure possessing charming physicochemical characteristics, versatile bioactive properties, excellent drug loading delivery capabilities arise widespread attention achieved considerable achievements disease last decade. However, authors' best knowledge, no review has comprehensively summarized advances LDHs treating so far. Herein, advantages disorders outlined corresponding state-of-the-art first time. The potential LDHs-based nanocomposites extended therapeutics is highlighted perspectives scaffold design proposed facilitated translation.

Language: Английский

---

Recent advances using MXenes in biomedical applications

Materials Horizons, Journal Year: 2023, Volume and Issue: 11(4), P. 876 - 902

Published: Dec. 1, 2023

The structure of this review includes applications MXenes in drug delivery, tissue engineering, antimicrobial, and biosensors.

Language: Английский

---

Emerging 2D Nanomaterials‐Integrated Hydrogels: Advancements in Designing Theragenerative Materials for Bone Regeneration and Disease Therapy

Advanced Science, Journal Year: 2024, Volume and Issue: 11(31)

Published: June 14, 2024

Abstract This review highlights recent advancements in the synthesis, processing, properties, and applications of 2D‐material integrated hydrogels, with a focus on their performance bone‐related applications. Various synthesis methods types 2D nanomaterials, including graphene, graphene oxide, transition metal dichalcogenides, black phosphorus, MXene are discussed, along strategies for incorporation into hydrogel matrices. These composite hydrogels exhibit tunable mechanical high surface area, strong near‐infrared (NIR) photon absorption controlled release capabilities, making them suitable range regeneration therapeutic In cancer therapy, 2D‐material‐based show promise photothermal photodynamic therapies, drug delivery (chemotherapy). The properties these materials enable selective tumor ablation upon NIR irradiation, while drug‐loading capacity facilitates targeted chemotherapeutic agents. Additionally, 2D‐materials ‐infused potent antibacterial activity, effective against multidrug‐resistant infections disruption biofilm generated implant surface. Moreover, synergistic therapy approach combines multiple treatment modalities such as photothermal, chemo, immunotherapy to enhance outcomes. bio‐imaging, serve versatile contrast agents imaging probes, enabling real‐time monitoring during imaging. Furthermore, bone regeneration, most incorporated promote osteogenesis tissue offering potential solutions defects repair. Overall, integration presents promising platform developing multifunctional theragenerative biomaterials.

Language: Английский

---

A Se Nanoparticle/MgFe‐LDH Composite Nanosheet as a Multifunctional Platform for Osteosarcoma Eradication, Antibacterial and Bone Reconstruction

Advanced Science, Journal Year: 2024, Volume and Issue: 11(33)

Published: July 3, 2024

Despite advances in treating osteosarcoma, postoperative tumor recurrence, periprosthetic infection, and critical bone defects remain concerns. Herein, the growth of selenium nanoparticles (SeNPs) onto MgFe-LDH nanosheets (LDH) is reported to develop a multifunctional nanocomposite (LDH/Se) further modification on bioactive glass scaffold (BGS) obtain versatile platform (BGS@LDH/Se) for comprehensive osteosarcoma management. The uniform dispersion negatively charged SeNPs LDH surface restrains toxicity-inducing aggregation inactivation, thus enhancing superoxide dismutase (SOD) activation anion radical (·O

Language: Английский

---

Functional Antimicrobial Peptide-loaded 3D Scaffolds for Infected Bone Defect Treatment with AI and Multidimensional Printing

Materials Horizons, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Infection is the most prevalent complication of fractures, particularly in open and often leads to severe consequences.

Language: Английский

---

Advanced layered nanocomposites with controllable aligned channels for efficient solar-driven desalination

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 507, P. 160350 - 160350

Published: Feb. 7, 2025

Language: Английский

---

Anti‐Acidification and Immune Regulation by Nano‐Ceria‐Loaded Mg–Al Layered Double Hydroxide for Rheumatoid Arthritis Therapy

Advanced Science, Journal Year: 2023, Volume and Issue: 11(6)

Published: Dec. 8, 2023

Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease featuring an abnormal immune microenvironment and resultant accumulation of hydrogen ions (H + ) produced by activated osteoclasts (OCs). Currently, clinic RA therapy can hardly achieve sustained or efficient therapeutic outcomes due to the failures in generating sufficient modulation manipulating H that deteriorates bone damage. Herein, highly effective modulatory nanocatalytic platform, nanoceria‐loaded magnesium aluminum layered double hydroxide (LDH‐CeO 2 ), proposed for enhanced based on acid neutralization metal ion inherent bioactivity. Specifically, mild alkaline LDH initiates significant M2 repolarization macrophages triggered elevated antioxidation effect CeO via neutralizing excessive microenvironment, thus resulting recruitment regulatory T cell (Treg) suppressions helper 17 (Th 17) plasma cells. Moreover, osteogenic activity stimulated Mg released from LDH, thereby promoting damaged healing. The encouraging adjuvant‐induced model mice demonstrate high feasibility such concept, which provides novel modality bone‐repairing effects inorganic material.

Language: Английский

---