Thymoquinone as an electron transfer mediator to convert Type II photosensitizers to Type I photosensitizers DOI Creative Commons
Jiahao Zhuang, Guobin Qi,

Yecheng Feng

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 10, 2024

Abstract The development of Type I photosensitizers (PSs) is great importance due to the inherent hypoxic intolerance photodynamic therapy (PDT) in microenvironment. Compared II PSs, PSs are less reported absence a general molecular design strategy. Herein, we report that combination typical PS and natural substrate carvacrol (CA) can significantly facilitate pathway efficiently generate superoxide radical (O 2 –• ). Detailed mechanism study suggests CA activated into thymoquinone (TQ) by local singlet oxygen generated from upon light irradiation. With TQ as an efficient electron transfer mediator, it promotes conversion O via transfer-based pathway. Notably, three classical employed demonstrate universality proposed approach. PDT against S. aureus has been demonstrated under conditions vitro. Furthermore, this coupled agent exhibits significant bactericidal activity with antibacterial rate 99.6% for bacterial-infection female mice vivo experiments. Here, show simple, effective, universal method endow traditional tolerance.

Language: Английский

A Cascade Strategy Boosting Hydroxyl Radical Generation with Aggregation-Induced Emission Photosensitizers-Albumin Complex for Photodynamic Therapy DOI
Yulu Li, Di Zhang, Yuewen Yu

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(17), P. 16993 - 17003

Published: Aug. 22, 2023

Effective photodynamic therapy (PDT) requires photosensitizers (PSs) to massively generate type I reactive oxygen species (ROS) in a less oxygen-dependent manner the hypoxia tumor microenvironment. Herein, we present cascade strategy boost ROS, especially hydroxyl radical (OH·-), generation with an aggregation-induced emission (AIE) photosensitizer-albumin complex for hypoxia-tolerant PDT. The cationic AIE PS TPAQ-Py-PF6 (TPA = triphenylamine, Q anthraquinone, Py pyridine) contains three important moieties cooperatively enhance free generation: AIE-active TPA unit ensures effective triplet exciton aggregate, anthraquinone moiety possesses redox cycling ability promote electron transfer, while methylpyridinium cation further increases intramolecular charge transfer and separation processes. Inserting into hydrophobic domain of bovine serum albumin nanoparticles (BSA NPs) could greatly immobilize its molecular geometry increase generation, electron-rich microenvironment BSA ultimately leads OH·- generation. Both experimental theoretical results confirm effectiveness our cationization immobilization enhancing In vitro vivo experiments validate excellent antitumor PDT performance NPs, superior conventional polymeric encapsulation approach. Such multidimensional specially boosting shall hold great potential related applications.

Language: Английский

Citations

59
Lipid Droplet Targeting Type I Photosensitizer for Ferroptosis via Lipid Peroxidation Accumulation DOI
Tao Xiong, Yingchao Chen, Qiang Peng

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(4)

Published: Nov. 21, 2023

Abstract As an iron‐dependent lipid peroxidation (LPO) mediated cell death pathway, ferroptosis offers promises for anti‐tumor treatment. Photodynamic therapy (PDT) is ideal way to generate reactive oxygen species (ROS) LPO. However, the conventional PDT normally functions on subcellular organelles, such as endoplasmic reticulum, mitochondria, and lysosome, causing rapid before triggering ferroptosis. Herein, first droplet (Ld)‐targeting type I photosensitizer (PS) with enhanced superoxide anion (O 2 −· ) production, termed MNBS , reported. The newly designed PS selectively localizes at Ld in cells, causes cellular LPO accumulation by generating sufficient O upon irradiation, subsequently induces chronical PDT, achieving high‐efficient hypoxia normoxia. Theoretical calculations comprehensive characterizations indicate that targeting property generation of originate from elevated H‐aggregation tendency owing dispersed molecular electrostatic distribution. Further vivo studies using ‐encapsulated liposomes demonstrate excellent anti‐cancer efficacy well anti‐metastatic activity. This study a paradigm reinforced achieve ferroptosis‐mediated PDT.

Language: Английский

Citations

56
External physical field‐driven nanocatalytic cancer therapy DOI Creative Commons
Qingyuan Wu, Haoyuan Zhang, Huiyu Liu

et al.

BMEMat, Journal Year: 2023, Volume and Issue: 1(1)

Published: Feb. 14, 2023

Abstract Recently, variable nanocatalysts have provided novel, highly selective, minimally invasive strategies driven by external physical fields for cancer therapy. In the catalytic reaction, less toxic or nontoxic substances can be in situ converted into agents suppression. this review, we systematically summarize therapy based on different types of fields, including light, ultrasound, electricity, temperature, X‐ray, magnetic field, and microwave. The properties, mechanisms, advantages corresponding are also introduced. Importantly, considering rapid development nanomedicine, research progress is discussed. Finally, remaining challenges outlooks that faced outlined. We believe emerging fields‐driven nanocatalytic will provide a new avenue treatment.

Language: Английский

Citations

53
Nanoprobe-based molecular imaging for tumor stratification DOI

Xianbin Ma,

Mingchuan Mao,

Jiaqi He

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(18), P. 6447 - 6496

Published: Jan. 1, 2023

This review highlights the use of nanoprobes to stratify various therapeutic modalities and provides an outlook on challenges future directions for patient stratification.

Language: Английский

Citations

50
Interrelation between Programmed Cell Death and Immunogenic Cell Death: Take Antitumor Nanodrug as an Example DOI
Qi Meng, Binbin Ding,

Ping’an Ma

et al.

Small Methods, Journal Year: 2023, Volume and Issue: 7(5)

Published: Jan. 27, 2023

Abstract Programmed cell death (PCD, mainly including apoptosis, necrosis, ferroptosis, pyroptosis, and autophagy) immunogenic (ICD), as important mechanisms, are widely reported in cancer therapy, understanding the relationship between two is significant for clinical tumor treatments. Considering that vast nanodrugs developed to induce PCD ICD simultaneously, this review, interrelationship described using nanomedicines examples. First, an overview of patterns focus on morphological differences interconnections among them provided. Then apoptosis terms endoplasmic reticulum stress by introducing various treatments recent developments with inducible immunogenicity. Next, crosstalk non‐apoptotic (including signaling pathways introduced their through examples further illustrated. Finally, its application prospects development new nanomaterials summarized. This review believed deepen ICD, extend biomedical applications nanodrugs, promote progress therapy.

Language: Английский

Citations

49
A Mild Hyperthermia Hollow Carbon Nanozyme as Pyroptosis Inducer for Boosted Antitumor Immunity DOI
Na Tao, Lei Jiao, Huihuang Li

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(22), P. 22844 - 22858

Published: Nov. 9, 2023

The immune checkpoint blockade (ICB) antibody immunotherapy has demonstrated clinical benefits for multiple cancers. However, the efficacy of in tumors is suppressed by deficient tumor immunogenicity and immunosuppressive microenvironments. Pyroptosis, a form programmed cell death, can release antigens, activate effective immunogenicity, improve efficiency ICB, but efficient pyroptosis treatment currently limited. Herein, we show mild hyperthermia-enhanced pyroptosis-mediated based on hollow carbon nanozyme, which specifically amplify oxidative stress-triggered synchronously magnify anticancer responses microenvironment. sphere modified with iron copper atoms (HCS-FeCu) enzyme-mimicking activities been engineered to induce via radical oxygen species (ROS)-Tom20-Bax-Caspase 3-gasdermin E (GSDME) signaling pathway under light activation. Both vitro vivo antineoplastic results confirm superiority HCS-FeCu nanozyme-induced pyroptosis. Moreover, photothermal-activated combining anti-PD-1 enhance antitumor immunotherapy. Theoretical calculations further indicate that photothermal stimulation generates high-energy electrons enhances interaction between surface adsorbed oxygen, facilitating molecular activation, improves ROS production efficiency. This work presents an approach effectively transforms immunologically "cold" into "hot" ones, significant implications

Language: Английский

Citations

48
Type I Photosensitizer Targeting G‐Quadruplex RNA Elicits Augmented Immunity for Cancer Ablation DOI
Wen Chen, Yuan Zhang, Haibo Yi

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(17)

Published: March 1, 2023

Type I photodynamic therapy (PDT) represents a promising treatment modality for tumors with intrinsic hypoxia. However, type photosensitizers (PSs), especially ones near infrared (NIR) absorption, are limited and their efficacy needs improvement via new targeting tactics. We develop NIR PS by engineering acridinium derived donor-π-acceptor systems. The exhibits an exclusive PDT mechanism due to effective intersystem crossing disfavored energy transfer O2 , shows selective binding G-quadruplexes (G4s) hydrogen bonds identified molecular docking study. Moreover, it enables fluorogenic detection of G4s efficient ⋅- production in hypoxic conditions, leading immunogenic cell death substantial variations gene expression RNA sequencing. Our strategy demonstrates augmented antitumor immunity ablation cold tumor, highlighting its potential RNA-targeted precision cancer therapy.

Language: Английский

Citations

44
NIR-II Light-Driven Genetically Engineered Exosome Nanocatalysts for Efficient Phototherapy against Glioblastoma DOI

Xueyang Fang,

Rui Gong,

Decai Yang

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(22), P. 15251 - 15263

Published: May 23, 2024

Glioblastoma (GBM) poses a significant therapeutic challenge due to its invasive nature and limited drug penetration through the blood–brain barrier (BBB). In response, here we present an innovative biomimetic approach involving development of genetically engineered exosome nanocatalysts (Mn@Bi2Se3@RGE-Exos) for efficient GBM therapy via improving BBB enzyme-like catalytic activities. Interestingly, photothermally activatable multiple reactivity is observed in such nanosystem. Upon NIR-II light irradiation, Mn@Bi2Se3@RGE-Exos are capable converting hydrogen peroxide into hydroxyl radicals, oxygen, superoxide providing peroxidase (POD), oxidase (OXD), catalase (CAT)-like nanocatalytic cascade. This consequently leads strong oxidative stresses damage cells. vitro, vivo, proteomic analysis further reveal potential disruption cellular homeostasis, enhancement immunological induction cancer cell ferroptosis, showcasing great promise anticancer efficacy against with favorable biosafety profile. Overall, success this study provides feasible strategy future design clinical stimuli-responsive medicine, especially context challenging brain cancers like GBM.

Language: Английский

Citations

24
Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy DOI Creative Commons
Hai Xu, Dahee Kim, Yuanyuan Zhao

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(27)

Published: March 29, 2024

Cancer treatment requires precise tumor-specific targeting at specific sites that allows for high-resolution diagnostic imaging and long-term patient-tailorable cancer therapy; while, minimizing side effects largely arising from non-targetability. This can be realized by harnessing exogenous remote stimuli, such as tissue-penetrative ultrasound, magnetic field, light, radiation, enable local activation therapy in deep tumors. A myriad of nanomedicines efficiently activated when the energy stimuli transformed into another type energy. review discusses control transformation targetable, efficient, therapy. Such ultrasonic, magnetic, photonic, radiative, radioactive mechanical, thermal, chemical, radiative to a variety modalities. The current article describes multimodal where serial cascade or multiple types occur. includes not only hyperthermia, radiation but also emerging thermoelectric, pyroelectric, piezoelectric therapies treatment. It illustrates resonance, fluorescence, computed tomography, photoluminescence, photoacoustic imaging-guided therapies. highlights afterglow eliminate autofluorescence sustained signal emission after excitation.

Language: Английский

Citations

22
Photocatalytic Carbon Dots‐Triggered Pyroptosis for Whole Cancer Cell Vaccines DOI Creative Commons
Quansheng Cheng, Tesen Zhang, Qingcheng Wang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 12, 2024

Abstract Manufacturing whole cancer cell vaccines (WCCV) with both biosafety and efficacy is crucial for tumor immunotherapy. Pyroptotic cells, due to their highly immunogenic properties, present a promising avenue the development of WCCV. However, successful WCCV based on pyroptotic cells yet be accomplished. Here, facile strategy that utilized photocatalytic carbon dots (CDs) induce pyroptosis fabricating reported. Photocatalytic CDs are capable generating substantial amounts hydroxyl radicals can effectively decrease cytoplasmic pH values under white light irradiation. This process efficiently triggers through reactive oxygen species (ROS)‐mitochondria‐caspase 3‐gasdermin E pathway proton motive force‐driven mitochondrial ATP synthesis pathway. Moreover, in vitro, these CDs‐induced (PCIP) hyperactivate macrophage (M0–M1) upregulation major histocompatibility complex class II expression. In vivo, PCIP induced specific immune‐preventive effects melanoma breast mouse models anticancer immune memory, demonstrating effective work provides novel insights inducing bridges gap fabrication cells.

Language: Английский

Citations

21