Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 2, 2025
Chemiluminescence
(CL)
is
a
self-illuminating
phenomenon
fueled
by
chemical
energy
instead
of
extra
excited
light,
which
features
superiority
in
sensitivity,
signal-to-background
ratios,
and
imaging
depth.
Strategies
to
synthesize
CL
emission
unimolecular
skeleton
the
second
near-infrared
window
(NIR-II)
probe
with
direct
duplex
NIR-II
[CL/fluorescence
(FL)]
are
lacking.
Here,
we
employ
modular
synthesis
routes
construct
series
directly
activated
probes
maximum
wavelength
up
1060
nm,
use
them
for
real-time
continuous
detection
superoxide
anion
generated
acetaminophen
induced
liver
injury
female
mice
model
under
both
FL
channels.
Thus,
this
study
establishes
activatable
skeleton,
validating
scalability
CL/FL
platform
bioactive
molecule
disease
diagnosis.
chemiluminescence
authors
NIRII
iScience,
Journal Year:
2024,
Volume and Issue:
27(3), P. 109223 - 109223
Published: Feb. 15, 2024
SummaryIn
recent
years,
significant
advancements
have
been
made
in
the
synthesis
and
application
of
1,3-dienes.
This
specific
structural
motif
has
garnered
attention
from
researchers
materials
science
biology
due
to
its
unique
aggregation-induced
emission
(AIE)
properties
extensive
conjugation
systems.
The
luminescent
characteristics
these
compounds
are
notably
influenced
by
geometry
two
double
bonds.
Therefore,
it
is
essential
consolidate
stereoselective
synthetic
strategies
for
comprehensive
review
seeks
elucidate
diverse
techniques
employed
attain
stereo-control
1,3-diene-based
AIE
luminogens
(AIEgens).
Particular
emphasis
placed
on
comprehending
determinants
stereoselectivity
exploring
array
substrates
amenable
methods.
Furthermore,
underscores
exhibited
their
utility
organic
light-emitting
diodes
(OLEDs),
stimuli-responsive
materials,
sensors,
bioimaging,
photodynamic
therapy
(PDT).Graphical
abstract
Biophysics and Physicobiology,
Journal Year:
2024,
Volume and Issue:
21(Supplemental), P. n/a - n/a
Published: Jan. 1, 2024
Bioluminescence
imaging
has
recently
attracted
great
attention
as
a
highly
sensitive
and
non-invasive
analytical
method.
However,
weak
signal
low
chemical
stability
of
the
luciferin
are
conventional
drawbacks
bioluminescence
imaging.
In
this
review
article,
we
describe
recent
progress
on
development
applications
bioluminescent
probes
for
overcoming
aforementioned
limitations,
thereby
enabling
spatiotemporal
trans-scale
The
detailed
molecular
design
manipulation
their
luminescent
properties
functions
enabled
variety
applications,
including
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(36), P. 7601 - 7606
Published: Sept. 4, 2024
Dithiane
chemistry
is
increasingly
advantageous
in
the
development
of
novel
anion
relay
(ARC)
modes
that
harness
their
umpolung
properties
to
address
new
chemical
challenges.
Herein,
we
report
use
an
ARC
strategy
promote
regioselective
carbonyl
alkyne
metathesis
(CAM)
various
compounds
with
alkynyl
1,3-dithianes.
Notably,
this
transformation
provides
a
platform
for
obtaining
stereodefined
polysubstituted
1,3-dienes.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 9, 2025
Bioimaging
technology
has
been
broadly
used
in
biomedicine,
and
the
growth
of
multimodal
imaging
based
on
synergistic
advantages
can
overcome
shortcomings
traditional
single-modal
bioimaging
methods
attain
high
specificity
sensitivity
fields
biosensing.
The
analysis
low-abundance
microRNAs
(miRNAs)
complex
organisms
is
importance
for
early-stage
diagnosis
clinical
treatment
tumors.
In
our
current
study,
a
biosensing
nanoplatform
Tf-AuNCs
MnO2
nanosheets
was
developed
tumor
cells.
First,
oxidizable
provided
smart
tool
use
as
nanocarriers
contrast
agents
intracellular
glutathione
(GSH)-activated
magnetic
resonance
(MRI).
Then,
delivered
Tf-AuNC-based
nanoplatforms
into
cells
through
endocytosis.
Endogenous
GSH
degraded
Mn2+,
released
functional
nucleic
acid
probes
perform
specific
responses
to
miR-21
exhibiting
including
two-photon
near-infrared
fluorescence
(TP-NIRFI),
lifetime
(FLIM),
MRI.
Finally,
achieved
satisfactory
results
tissues
by
TP-NIRFI
(300.0
μm
penetration
depth),
FLIM
(τ
≈
50.0
ns),
Therefore,
show
great
potential
detection
Analytical Sciences,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 28, 2025
Near-infrared
I
(NIR-I:
650–950
nm)
fluorescence
imaging
is
a
powerful
tool
for
deep-tissue
biological
imaging,
addressing
the
limitations
of
photon
penetration
depth
in
visible-light
region.
Over
past
decade,
NIR
has
extended
to
near-infrared
II
(NIR-II:
1000–1700
region,
offering
high-resolution
and
low
background
by
suppressing
light
scattering,
autofluorescence
tissues.
fluorescent
probes
from
NIR-I
NIR-II,
with
diverse
functionalities,
are
increasingly
utilized
across
fields
meet
various
detection
needs
explore
physiological
events
real
time
spatial
dimensions.
This
review
discusses
recent
advancements
small-molecule
dyes
probes,
particularly
those
based
on
cyanine
rhodamine
scaffolds,
highlighting
examples
their
applications
bioimaging.
Asian Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 11, 2025
Abstract
Polymethine
cyanine
dyes
have
witnessed
significant
advancements
in
bioimaging
and
phototherapy
due
to
their
optical
properties
ease
of
modification.
This
review
categorizes
introduces
typical
synthesis
Cy3,
Cy5,
Cy7
longer
polymethine
dyes,
highlights
organic‐specific
in‐cell
cyanines
via
the
newly‐established
pseudo‐trimerization
method
using
a
single
exogenous
precursor
activatable
by
visible
light,
free
radicals
or
reactive
oxygen
species.
Further
discussions
delve
into
functionalization
strategies
structure‐activity
relationships
summarizes
bioapplications
fluorescence
imaging,
multimodal
assisted
diagnosis
treatments,
aiming
unlock
full
potential
scientific
research
clinical
translation.
Journal of Medicinal Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 28, 2025
Photocleavable
protecting
groups
hold
great
promise
in
photopharmacology
to
control
the
release
of
bioactive
molecules
from
their
caged
precursors
within
specific
subcellular
compartments.
Herein,
we
describe
a
series
photocages
based
on
COUPY
scaffold,
incorporating
chlorambucil
(CLB)
and
4-phenylbutyric
acid
(4-PBA)
as
payloads
that
can
be
efficiently
activated
with
visible
light.
Confocal
microscopy
confirmed
preferential
accumulation
CLB
4-PBA
N-hexyl
mitochondria,
which
exhibited
remarkable
phototoxicity
against
cancer
cells
upon
green-yellow
light
irradiation,
IC50
values
nanomolar
range.
This
effect
was
attributed
synergistic
mechanism
involving
photorelease
intrinsic
photogeneration
Type
I
II
ROS
by
scaffold
mitochondria.
Thus,
COUPY-caged
derivatives
underscore
potential
COUPY-caging
versatile
platform
develop
innovative
light-activated
agents
operating
simultaneously
through
photodynamic
therapy
photoactivated
chemotherapy.
Neurophotonics,
Journal Year:
2024,
Volume and Issue:
11(02)
Published: Feb. 22, 2024
Bioluminescence
is
a
popular
modality
for
imaging
in
living
organisms.
The
platform
relies
on
enzymatically
(luciferase)
generated
light
via
the
oxidation
of
small
molecule
luciferins.
Since
no
external
needed
photon
production,
there
are
concerns
with
background
autofluorescence
or
photobleaching
over
time-features
that
have
historically
limited
other
optical
readouts.
thus
routinely
used
longitudinal
tracking
across
whole
animals.
Applications
brain,
though,
been
more
challenging
due
to
lack
sufficiently
bioavailable,
bright,
and
easily
multiplexed
probes.
Recent
years
seen
development
designer
luciferase
luciferin
pairs
address
these
issues,
providing
sensitive
real-time
readouts
biochemical
features
relevant
neurobiology.
This
review
highlights
many
advances
bioluminescent
probe
design,
focus
emitter,
luciferin.
Specific
efforts
improve
pharmacokinetics
tissue-penetrant
emission
covered,
addition
applications
such
probes
enabled.
continued
improved
will
aid
illuminating
critical
neurochemical
processes
brain.
