A Multifunctional Covalent Organic Framework Nanozyme for Promoting Ferroptotic Radiotherapy against Esophageal Cancer

ACS Nano, Journal Year: 2023, Volume and Issue: 17(20), P. 20445 - 20461

Published: Oct. 6, 2023

Radiotherapy is inevitably accompanied by some degree of radiation resistance, which leads to local recurrence and even therapeutic failure. To overcome this limitation, herein, we report the room-temperature synthesis an iodine- ferrocene-loaded covalent organic framework (COF) nanozyme, termed TADI-COF-Fc, for enhancement radiotherapeutic efficacy in treatment radioresistant esophageal cancer. The iodine atoms on COF not only exerted a direct effect radiotherapy, increasing its X-ray absorption, but also promoted radiolysis water, increased production reactive oxygen species (ROS). In addition, ferrocene surface decoration disrupted redox homeostasis levels hydroxyl lipid peroxide radicals depleting intracellular antioxidants. Both vitro vivo experiments substantiated excellent response TADI-COF-Fc. This study demonstrates potential COF-based multinanozymes as radiosensitizers suggests possible integration strategy combination oncotherapy.

Language: Английский

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Selenium‐Doped Nanoheterojunctions for Highly Efficient Cancer Radiosensitization

Advanced Science, Journal Year: 2024, Volume and Issue: 11(29)

Published: June 3, 2024

Abstract Exploring efficient and low‐toxicity radiosensitizers to break through the bottleneck of radiation tolerance, immunosuppression poor prognosis remains one critical developmental challenges in radiotherapy. Nanoheterojunctions, due their unique physicochemical properties, have demonstrated excellent radiosensitization effects energy deposition lifting tumor radiotherapy inhibition. Herein, they doped selenium (Se) into prussian blue (PB) construct a nano‐heterojunction (Se@PB), which could promote increase Fe 2+ /Fe 3+ ratio conversion Se high valence state with introduction. The ‐Se‐Fe electron transfer chain accelerates rate on surface nanoparticles, turn endows it X‐ray transport capability, enhances physical sensitivity. Furthermore, Se@PB induces glutathione (GSH) depletion accumulation pro‐Fenton reaction, thereby disturbs redox balance cells biochemical sensitivity As an radiosensitizer, effectively induced mitochondrial dysfunction DNA damage, promotes cell apoptosis synergistic cervical cancer This study elucidates mechanism Se‐doped nanoheterojunction from perspective biochemistry provides low‐toxic strategy

Language: Английский

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Radiotherapy-triggered reduction of platinum-based chemotherapeutic prodrugs in tumours

Nature Biomedical Engineering, Journal Year: 2024, Volume and Issue: 8(11), P. 1425 - 1435

Published: July 18, 2024

Language: Английский

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A Cancer Nanovaccine Based on an FeAl-Layered Double Hydroxide Framework for Reactive Oxygen Species-Augmented Metalloimmunotherapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(11), P. 8143 - 8156

Published: March 4, 2024

The complexity and heterogeneity of individual tumors have hindered the efficacy existing therapeutic cancer vaccines, sparking intensive interest in development more effective situ vaccines. Herein, we introduce a nanovaccine for reactive oxygen species-augmented metalloimmunotherapy which FeAl-layered double hydroxide (LDH) is used as delivery vehicle with dihydroartemisinin (DHA) cargo. LDH framework acid-labile can be degraded tumor microenvironment, releasing iron ions, aluminum DHA. ions contribute to aggravated intratumoral oxidative stress injury by synergistic Fenton reaction DHA activation, causing apoptosis, ferroptosis, immunogenic cell death cells. subsequently released tumor-associated antigens adjuvant form generate robust long-term immune responses against recurrence metastasis. Moreover, Fe ion-enabled T1-weighted magnetic resonance imaging facilitate real-time therapy monitoring. This cancer-nanovaccine-mediated strategy has potential revolutionizing precision immunotherapy landscape.

Language: Английский

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MOF-on-MOF Growth: Inducing Naturally Nonpreferred MOFs and Atypical MOF Growth

Accounts of Chemical Research, Journal Year: 2024, Volume and Issue: 57(21), P. 3113 - 3125

Published: Oct. 10, 2024

ConspectusOverflowing metal–organic frameworks (MOFs) have been synthesized from a wide range of metal and organic components for specific purposes intellectual curiosity. Each MOF has unique chemical structural characteristics directed by the incorporated components, ions (or clusters), linkers, their intrinsic coordination interactions. These are two pivotal factors influencing MOFs' fundamental properties subsequent applications. Therefore, selecting appropriate considering innate properties, is crucial to endow final MOFs with desired properties. Ultimately, producing structure using ideal best approach achieving tailored However, intended chosen remains underdeveloped. In many cases, resulting governed thermodynamically and/or kinetically preferred configuration (refers naturally structure) given reaction conditions. Additionally, hybrid complex structures, morphologies presents great opportunity obtain special advanced functions. this Account, we outline our group's efforts over past few years develop nonpreferred through induced MOF-on-MOF growth process atypical via nonstandard growth. First, highlight prime strategy based on template-induced section, discuss basic behaviors, isotropic anisotropic MOFs, determined degree matching between cell lattices MOFs. Second, introduce farming concept productive cultivation effective harvesting made Here importance template developing an efficient method cultivated Next, describe growths mismatched lattices. tip-to-middle involving self-structural adjustment secondary MOF, logical inference unidentified structures behavior morphological features, accompanied etching transformation template. Finally, perspectives challenges synthesis We hope that Account offers valuable insights into rational design development compositional characteristics, leading creation

Language: Английский

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Nanomaterial-based regulation of redox metabolism for enhancing cancer therapy

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This review provides a comprehensive summary of the dysregulation redox metabolism in cancer cells and advantages latest advances nanomaterial-assisted metabolic regulation therapy.

Language: Английский

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Localized In Vivo Prodrug Activation Using Radionuclides

Journal of Nuclear Medicine, Journal Year: 2025, Volume and Issue: 66(1), P. 91 - 97

Published: Jan. 1, 2025

Radionuclides used for imaging and therapy can show high molecular specificity in the body with appropriate targeting ligands. We hypothesized that local energy delivered by molecularly targeted radionuclides could chemically activate prodrugs at disease sites while avoiding activation off-target of toxicity. As proof principle, we tested whether this strategy radionuclide-induced drug engagement release (RAiDER) locally deliver combined radiation chemotherapy to maximize tumor cytotoxicity minimizing exposure activated chemotherapy. Methods: screened ability a model radiation-activated prodrug consisting microtubule-destabilizing monomethyl auristatin E (MMAE) caged radiation-responsive phenyl azide, interpreted experimental results using radiobiology computational simulation suite TOPAS-nBio. RAiDER was evaluated syngeneic mouse models cancer fibroblast protein inhibitor (FAPI) agents [^99mTc]Tc-FAPI-34 [¹⁷⁷Lu]Lu-FAPI-04 prostate-specific membrane antigen (PSMA) agent [¹⁷⁷Lu]Lu-PSMA-617, MMAE or exatecan. Biodistribution mice, clinical dosimetry, estimated relationship between radiopharmaceutical uptake patients anticipated concentrations RAiDER. Results: efficiency varied 70-fold across (^99mTc > ¹¹¹In ¹⁷⁷Lu ⁶⁴Cu ³²P ⁶⁸Ga ²²³Ra ¹⁸F), yielding up 320 nM activation/Gy from ^99mTc. Computational simulations implicated low-energy electron–mediated free radical formation as driving activation. Radionuclide-activated restored prodrug's destabilize microtubules increased its 2,600-fold nonactivated prodrug. Mice treated accumulated were 3,000 times greater tumors than other tissues. delayed growth, whereas monotherapies did not (P < 0.003). Clinically guided dosimetry suggests sufficient doses be therapeutically meaningful levels Conclusion: This proof-of-concept study shows is compatible multiple commonly nuclear medicine potentially improve efficacy therapies treat safely. thus promise an effective disseminated malignancies broadens capability radiopharmaceuticals trigger diverse biologic therapeutic responses.

Language: Английский

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MOFs-based porous liquids for CO2 capture and utilization

Green Energy & Environment, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Nanotheranostics with Radionuclides for Cancer Diagnosis and Therapy

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Abstract Anti‐tumor theranostic radionuclide nanosystems have gained significant attention as an emerging therapeutic strategy. This review systematically elucidates the concept and recent advances of anti‐tumor nanotheranostic systems with radionuclides, a focus on design nanocarriers, precise selection their advantages limitations in clinical translation. also explores integration imaging various treatment modalities, including photodynamic therapy, photothermal sonodynamic immunotherapy. Furthermore, combination therapy fluorescence magnetic resonance technologies, which broadens application nanotheranostics, is discussed. Finally, outlooks future development nanotheranostics radionuclides proposes key research focus.

Language: Английский

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Hybrid Nanoplatforms Based on Photosensitizers and Metal/Covalent Organic Frameworks for Improved Cancer Synergistic Treatment Nano-Delivery Systems

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 884 - 884

Published: Feb. 14, 2025

Researchers have extensively investigated photosensitizer (PS) derivatives for various applications due to their superior photophysical and electrochemical properties. However, inherent problems, such as instability self-quenching under physiological conditions, limit biological applications. Metal-organic frameworks (MOFs) covalent organic (COFs) represent two relatively new material types. These materials high surface areas permanent porosity, they show a tremendous deal of potential like these. This review summarizes key synthesis processes highlights recent advancements in integrating PS-based COF MOF nanocarriers biomedical while addressing obstacles prospects.

Language: Английский

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