Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(27)

Published: March 29, 2024

Cancer treatment requires precise tumor-specific targeting at specific sites that allows for high-resolution diagnostic imaging and long-term patient-tailorable cancer therapy; while, minimizing side effects largely arising from non-targetability. This can be realized by harnessing exogenous remote stimuli, such as tissue-penetrative ultrasound, magnetic field, light, radiation, enable local activation therapy in deep tumors. A myriad of nanomedicines efficiently activated when the energy stimuli transformed into another type energy. review discusses control transformation targetable, efficient, therapy. Such ultrasonic, magnetic, photonic, radiative, radioactive mechanical, thermal, chemical, radiative to a variety modalities. The current article describes multimodal where serial cascade or multiple types occur. includes not only hyperthermia, radiation but also emerging thermoelectric, pyroelectric, piezoelectric therapies treatment. It illustrates resonance, fluorescence, computed tomography, photoluminescence, photoacoustic imaging-guided therapies. highlights afterglow eliminate autofluorescence sustained signal emission after excitation.

Language: Английский

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Selenium electrophilic center shuttles active electrons to boost mitochondrial electron leakage

Published: Feb. 1, 2025

Language: Английский

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Controlled In Situ Self-Assembly of Biotinylated Trans-Cyclooctene Nanoparticles for Orthogonal Dual-Pretargeted Near-Infrared Fluorescence and Magnetic Resonance Imaging

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(19), P. 13163 - 13175

Published: May 3, 2024

A pretargeted strategy that decouples targeting vectors from radionuclides has shown promise for nuclear imaging and/or therapy in vivo. However, the current approach relies on use of antibodies or nanoparticles as vectors, which may be compromised by poor tissue penetration and limited accumulation tumor tissues. Herein, we present an orthogonal dual-pretargeted combining stimuli-triggered situ self-assembly with fast inverse electron demand Diels-Alder (IEDDA) reaction strong biotin-streptavidin (SA) interaction near-infrared fluorescence (NIR FL) magnetic resonance (MR) tumors. This uses a small-molecule probe (P-Cy-TCO&Bio) containing both biotin trans-cyclooctene (TCO) tumor-targeting vector. P-Cy-TCO&Bio can efficiently penetrate subcutaneous HeLa tumors through biotin-assisted targeted delivery undergo to form biotinylated TCO-bearing (Cy-TCO&Bio NPs) cell membranes. Cy-TCO&Bio NPs exhibited "off-on" NIR FL retained tumors, offering high density TCO groups concurrent capture Gd-chelate-labeled tetrazine (Tz-Gd) IR780-labeled SA (SA-780) via IEDDA SA-biotin interaction. Moreover, offered multiple-valent binding modes toward SA, additionally regulated cross-linking Cy-Gd&Bio into microparticles (Cy-Gd&Bio/SA MPs). process could significantly (1) increase

Language: Английский

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Magneto-optical nanosystems for tumor multimodal imaging and therapy in-vivo

Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101027 - 101027

Published: March 16, 2024

Multimodal imaging, which combines the strengths of two or more imaging modalities to provide complementary anatomical and molecular information, has emerged as a robust technology for enhancing diagnostic sensitivity accuracy, well improving treatment monitoring. Moreover, application multimodal in guiding precision tumor can prevent under- over-treatment, thereby maximizing benefits patients. In recent years, several intriguing magneto-optical nanosystems with both magnetic optical properties have been developed, leading significant breakthroughs field image-guided therapy. These advancements pave way precise medicine. This review summarizes various types developed recently describes their applications probes agents therapeutic interventions. Finally, future research development prospects are discussed along an outlook on further biomedical field.

Language: Английский

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Organic dye-based photosensitizers for fluorescence imaging-guided cancer phototheranostics

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 513, P. 215866 - 215866

Published: May 2, 2024

Language: Английский

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Simultaneously enhancing organic phosphorescence quantum yields and lifetimes for triphenylphosphine salt doped polymer films

Chemical Science, Journal Year: 2024, Volume and Issue: 15(13), P. 4881 - 4889

Published: Jan. 1, 2024

Simultaneously enhancing the quantum yields and luminescence lifetimes of organic persistent room temperature phosphorescence (RTP) molecules is a priority in photonic area, but it remains formidable challenge. Here, an effective strategy was proposed to improve both efficiencies emission decay times for phosphorescent triphenylphosphine salts. This approach involves integrating electron donor unit into salt

Language: Английский

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A β-Galactosidase-Activated Fluorogenic Reporter for the Detection of Gastric Cancer In Vivo and in Urine

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(16), P. 6390 - 6397

Published: April 12, 2024

Although gastric cancer (GC) is one of the most frequent malignant tumors in digestive tract with high morbidity and mortality, it remains a diagnostic dilemma due to its reliance on invasive biopsy or insensitive assays. Herein, we report fluorescent reporter (FGCR) activatable near-infrared fluorescence (NIRF) signals renal-clearance efficiency for detection orthotopic GC murine model via real-time imaging remote urinalysis. In presence gastric-tumor-associated β-galactosidase (β-Gal), FGCR can be fluorescently activated vivo NIRF imaging. Relying (∼95% ID), rapidly excreted through kidneys urine ultrasensitive diameter down ∼2.1 mm assessing prognosis oxaliplatin-based chemotherapy. This study not only provides new approach noninvasive auxiliary diagnosis but also guidelines development probes diagnosis.

Language: Английский

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Ratiometric Afterglow Luminescent Imaging of Matrix Metalloproteinase‐2 Activity via an Energy Diversion Process

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(26)

Published: April 19, 2024

Ratiometric afterglow luminescent (AGL) probes are attractive for in vivo imaging due to their high sensitivity and signal self-calibration function. However, there currently few ratiometric AGL available enzymatic activity living organisms. Here, we present an energy diversion (ED) strategy that enables the design of enzyme-activated probe (RAG-RGD) imaging. The ED process provides RAG-RGD with a radiative transition 'always on' 520-nm (AGL

Language: Английский

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Sonosynthetic Cyanobacteria Oxygenation for Self‐Enhanced Tumor‐Specific Treatment

Advanced Science, Journal Year: 2024, Volume and Issue: 11(29)

Published: June 12, 2024

Abstract Photosynthesis, essential for life on earth, sustains diverse processes by providing nutrition in plants and microorganisms. Especially, photosynthesis is increasingly applied disease treatments, but its efficacy substantially limited the well‐known low penetration depth of external light. Here, ultrasound‐mediated reported enhanced sonodynamic tumor therapy using organic sonoafterglow (ultrasound‐induced afterglow) nanoparticles combined with cyanobacteria, demonstrating proof‐of‐concept sonosynthesis (sonoafterglow‐induced photosynthesis) cancer therapy. Chlorin e6, a typical small‐molecule chlorine, formulated into to stimulate cyanobacteria sonosynthesis, which serves three roles, i.e., overcoming tissue‐penetration limitations light sources, reducing hypoxia, acting as sonosensitizer vivo suppression. Furthermore, sonosynthetic oxygenation suppresses expression hypoxia‐inducible factor 1α, leading reduced stability downstream SLC7A11 mRNA, results glutathione depletion inactivation peroxidase 4, thereby inducing ferroptosis cells. This study not only broadens scope microbial nanomedicine also offers distinct direction sonosynthesis.

Language: Английский

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Unveiling the potential of triphenylphosphine salts in tuning organic room temperature phosphorescence

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(70), P. 9328 - 9339

Published: Jan. 1, 2024

This article summarizes the potential of TPP salts in tuning RTP properties and their applications multi-level information encryption, high-level anticounterfeiting tags, X-ray scintillators.

Language: Английский

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