Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(42), P. 10818 - 10834
Published: Jan. 1, 2024
Prodrugs, activated at the tumor site, offer targeted treatment but may still cause unintended cytotoxicity. This review explores combination of bioorthogonal reactions with prodrug strategies to improve safety and efficacy.
Language: Английский
Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.
Language: Английский
Citations
4
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155083 - 155083
Published: Aug. 23, 2024
Language: Английский
Citations
5
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 5, 2024
Abstract Chemical reactions underpin biological processes, and imbalances in critical biochemical pathways within organisms can lead to the onset of severe diseases. Within this context, emerging field “Nanocatalytic Medicine” leverages nanomaterials as catalysts modulate fundamental chemical specific microenvironments This approach is designed facilitate targeted synthesis localized accumulation therapeutic agents, thus enhancing treatment efficacy precision while simultaneously reducing systemic side effects. The effectiveness these nanocatalytic strategies critically hinges on a profound understanding kinetics intricate interplay particular pathological ensure effective catalytic actions. review methodically explores situ their associated biomaterials, emphasizing regulatory that control responses. Furthermore, discussion encapsulates crucial elements‐reactants, catalysts, reaction conditions/environments‐necessary for optimizing thermodynamics reactions, rigorously addressing both biophysical dimensions disease enhance outcomes. It seeks clarify mechanisms underpinning biomaterials evaluate potential revolutionize across various conditions.
Language: Английский
Citations
4
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 1 - 13
Published: Jan. 7, 2025
Keloids are pathological scars characterized by excessive fibroblast proliferation, abnormal collagen deposition, and chronic inflammation, which often result in high recurrence rates limited treatment success. Targeting BACH1 with gene therapy has shown promise regulating activity reducing inflammation. However, effective delivery systems for targeted keloids remain a major challenge. Here, we develop novel nanocarrier platform based on orthogonal upconversion nanoparticles (OUNCs) to achieve spatiotemporal silencing of combined photodynamic (PDT). The OUNCs composed (UCNPs), photosensitizer (Rose Bengal), ROS-sensitive diselenide bonds (SeSe), therapeutic siBACH1, an active targeting moiety (hyaluronic acid) specifically target keloid fibroblasts (KFs). We demonstrate that the can effectively induce KFs apoptosis, inhibit reduce M2 macrophages recruitment modulating Rap1/MEK/ERK signaling pathway. Our study represents breakthrough precision keloids, providing promising integrates siBACH1-based NIR light-triggered PDT.
Language: Английский
Citations
0
Nano Letters, Journal Year: 2025, Volume and Issue: unknown
Published: March 18, 2025
Glaucoma is characterized by high intraocular pressure (IOP), oxidative stress, and distinct optic nerve damage. Natural enzymes have unparalleled advantages in the treatment of glaucoma due to their efficiency, specificity, selectivity. However, poor stability recoverability constrained application. The selection good immobilization carriers an effective strategy protect natural enzymes. Here, we employ a mild room-temperature aqueous-phase enzyme technique immobilize superoxide dismutase catalase. Then, l-arginine added pores further modified with DSPE-mPEG construct bioorthogonal catalytic factory (SC@COF-L-D) excellent biocompatibility. This greatly protects from inactivation improves operational stability. SC@COF-L-D can scavenge large amount reactive oxygen species reduce oxidative/nitrative damage activate soluble guanylate cyclase pathway, thereby lowering IOP for glaucoma. work provides paradigm design materials therapy.
Language: Английский
Citations
0
Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 30, 2024
The revolutionary impact of photoredox catalytic processes has ignited novel avenues for exploration, empowering us to delve into nature in unprecedented ways and pioneer innovative biotechnologies therapy diagnosis. However, integrating artificial catalysis living systems presents significant challenges, primarily due concerns over low targetability, compatibility with complex biological environments, the safety risks associated photocatalyst toxicity. To address these herein, we present a bioorthogonally activatable approach. In this approach, potent selection via atom replacement rhodamine core yielded (PC-Tz). introduction 1,2,4,5-tetrazine quenched its photocatalytic properties, which were restored upon an intracellular inverse electron-demand Diels–Alder (iEDDA) reaction trans-cyclooctene (TCO) localized mitochondria. This led remarkable oxidation nicotinamide adenine dinucleotide (NADH), effectively manipulating mitochondrial electron transport chain (ETC) under hypoxic conditions cancer cells. Additionally, pyroptotic cell death was observed through caspase-3/gasdermin E (GSDME) pathway, achieving notable antitumor efficacy adenosine triphosphate (ATP) reduction tumor best our knowledge, represents first example catalysis, opening new chemists spatiotemporally control activity specific organelles without disrupting other native processes.
Language: Английский
Citations
3
Nano Today, Journal Year: 2025, Volume and Issue: 62, P. 102715 - 102715
Published: March 17, 2025
Language: Английский
Citations
0
Biomaterials Advances, Journal Year: 2025, Volume and Issue: unknown, P. 214341 - 214341
Published: May 1, 2025
Language: Английский
Citations
0
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 683, P. 398 - 407
Published: Dec. 14, 2024
Language: Английский
Citations
3
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(42), P. 10818 - 10834
Published: Jan. 1, 2024
Prodrugs, activated at the tumor site, offer targeted treatment but may still cause unintended cytotoxicity. This review explores combination of bioorthogonal reactions with prodrug strategies to improve safety and efficacy.
Language: Английский
Citations
0