Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(21), P. 13454 - 13619

Published: Sept. 28, 2021

This review presents a robust strategy to design photosensitizers (PSs) for various species. Photodynamic therapy (PDT) is photochemical-based treatment approach that involves the use of light combined with light-activated chemical, referred as PS. Attractively, PDT one alternatives conventional cancer due its noninvasive nature, high cure rates, and low side effects. PSs play an important factor in photoinduced reactive oxygen species (ROS) generation. Although concept photosensitizer-based photodynamic has been widely adopted clinical trials bioimaging, until now, our surprise, there no relevant article on rational designs organic PDT. Furthermore, most published articles focused nanomaterials nanotechnology based traditional PSs. Therefore, this aimed at reporting recent strategies develop innovative enhanced therapy, each example described detail instead providing only general overview, typically done previous reviews PDT, provide intuitive, vivid, specific insights readers.

Language: Английский

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Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation

Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 48(1), P. 38 - 71

Published: Nov. 2, 2018

Recent progress in developing organic semiconducting materials (OSMs) for deep-tissue optical imaging, cancer phototherapy and biological photoactivation is summarized.

Language: Английский

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Photochromism into nanosystems: towards lighting up the future nanoworld

Chemical Society Reviews, Journal Year: 2017, Volume and Issue: 47(3), P. 1044 - 1097

Published: Dec. 18, 2017

This review provides a state-of-the-art account of photochromism into diverse functional nanosystems such as nanomachines, nanoparticles, nanoelectronics, nanoassemblies and biological nanosystems.

Language: Английский

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Nanopharmaceuticals and Nanomedicines Currently on the Market: Challenges and Opportunities

Nanomedicine, Journal Year: 2018, Volume and Issue: 14(1), P. 93 - 126

Published: Nov. 19, 2018

There has been a revolution in nanotechnology and nanomedicine. Since 1980, there remarkable increase approved nano-based pharmaceutical products. These novel systems can either be therapeutic agents themselves, or else act as vehicles to carry different active into specific parts of the body. Currently marketed nanostructures include nanocrystals, liposomes lipid nanoparticles, PEGylated polymeric nanodrugs, other polymers, protein-based nanoparticles metal-based nanoparticles. A range issues must addressed development these nanostructures. Ethics, market size, possibility failure, costs commercial development, are some topics which on table discussed. After passing all ethical biological assessments, satisfying investors future profitability, only handful nanoformulations, successfully obtained marketing approval. We survey nanomedicines that have received regulatory approval marketed. discuss ethics, costs, possible failure. estimate global nanomedicine size growth. Our goal is summarize nanoformulations market, briefly cover challenges outlook.

Language: Английский

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Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing

Advanced Drug Delivery Reviews, Journal Year: 2017, Volume and Issue: 123, P. 33 - 64

Published: Aug. 4, 2017

Language: Английский

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Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials

Chemical Reviews, Journal Year: 2020, Volume and Issue: 120(24), P. 13135 - 13272

Published: Oct. 30, 2020

Photoactivatable (alternatively, photoremovable, photoreleasable, or photocleavable) protecting groups (PPGs), also known as caged photocaged compounds, are used to enable non-invasive spatiotemporal photochemical control over the release of species interest. Recent years have seen development PPGs activatable by biologically and chemically benign visible near-infrared (NIR) light. These long-wavelength-absorbing moieties expand applicability this powerful method its accessibility non-specialist users. This review comprehensively covers organic transition metal-containing photoactivatable compounds (complexes) that absorb in visible- NIR-range various leaving gasotransmitters (carbon monoxide, nitric oxide, hydrogen sulfide). The text NIR-light-induced photosensitized using molecular sensitizers, quantum dots, upconversion second-harmonic nanoparticles, well via photodynamic (photooxygenation singlet oxygen) photothermal effects. Release from polymers, micelles, vesicles, photoswitches, along with related emerging field photopharmacology, is discussed at end review.

Language: Английский

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Precise nanomedicine for intelligent therapy of cancer

Science China Chemistry, Journal Year: 2018, Volume and Issue: 61(12), P. 1503 - 1552

Published: Dec. 1, 2018

Language: Английский

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Semiconducting Polymer Nanomaterials as Near-Infrared Photoactivatable Protherapeutics for Cancer

Accounts of Chemical Research, Journal Year: 2020, Volume and Issue: 53(4), P. 752 - 762

Published: Feb. 6, 2020

Cancer therapy is routinely performed in the clinic to cure cancer and control its progression, wherein therapeutic agents are generally used. To reduce side effects, protherapeutic that can be activated by overexpressed biomarkers under development. However, these still face certain extent of off-target activation normal tissues, stimulating interest design external-stimuli activatable protherapeutics. In this regard, photoactivatable have been utilized for treatments. because intrinsic features photolabile moieties, most only respond ultraviolet-visible light, limiting their vivo applications. Thus, near-infrared (NIR) light with minimal phototoxicity increased tissue penetration highly desired.In Account, we summarize our semiconducting polymer nanomaterials (SPNs) as NIR treatment. SPNs transformed from π-conjugated polymers efficiently convert into heat or singlet oxygen (1O2). With photothermal photodynamic properties, directly used photomedicine serve transducers activate 1O2-responsive agents.The heat-activatable SPN-based developed loading conjugating (e.g., agonist, gene, enzyme). For instance, photothermally triggered release agonists specifically activates protein ion channels on cellular membrane, leading overinflux induced mitochondria dysfunction consequently apoptosis cells. Moreover, temperature-sensitive bromelain promote situ degradation collagens (the major components extracellular matrix), resulting an improved accumulation tumor tissues thus amplified outcome.The 1O2-activatable constructed through covalent conjugation caged via hypoxia- 1O2-cleavable linkers. Upon photoirradiation, consume generate 1O2, which leads (PDT), meanwhile breaks linkers on-demand molecules chemodrug, enzyme, inhibitor). Such remote applied induce DNA damage, ribonucleic acid degradation, inhibition biosynthesis, immune system tumors living animals. By synergizing PDT photoactivation those biological actions, effectively eliminate even fully inhibit metastasis.This Account highlights potential construction versatile protherapeutics treat at designated times locations high outcome precision.

Language: Английский

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Cell Membrane Coated Semiconducting Polymer Nanoparticles for Enhanced Multimodal Cancer Phototheranostics

ACS Nano, Journal Year: 2018, Volume and Issue: 12(8), P. 8520 - 8530

Published: Aug. 2, 2018

Phototheranostic nanoagents are promising for early diagnosis and precision therapy of cancer. However, their imaging ability therapeutic efficacy often limited due to the presence delivery barriers in tumor microenvironment. Herein, we report development organic multimodal phototheranostic that can biomimetically target cancer-associated fibroblasts microenvironment enhanced imaging-guided cancer therapy. Such biomimetic nanocamouflages comprise a near-infrared (NIR) absorbing semiconducting polymer nanoparticle (SPN) coated with cell membranes activated fibroblasts. The homologous targeting mechanism allows fibroblast membrane SPN (AF-SPN) specifically fibroblasts, leading accumulation relative uncoated counterparts after systemic administration living mice. As such, AF-SPN not only provides stronger NIR fluorescence photoacoustic signals detect tumors but also generates cytotoxic heat singlet oxygen exert combinational photothermal photodynamic therapy, ultimately an antitumor higher than counterparts. This study introduces system targets component theranostics.

Language: Английский

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Cyclodextrin‐Based Multistimuli‐Responsive Supramolecular Assemblies and Their Biological Functions

Advanced Materials, Journal Year: 2019, Volume and Issue: 32(3)

Published: Feb. 18, 2019

Cyclodextrins (CDs), which are a class of cyclic oligosaccharides extracted from the enzymatic degradation starch, often utilized in molecular recognition and assembly constructs, primarily via host-guest interactions water. In this review, recent progress CD-based supramolecular nanoassemblies that sensitive to chemical, biological, physical stimuli is updated reviewed, intriguing examples biological functions these presented, including pH- redox-responsive drug gene delivery, enzyme-activated specific cargo release, photoswitchable morphological interconversion, microtubular aggregation, cell-cell communication, as well geomagnetism-controlled nanosystem for suppression tumor invasion metastasis. Moreover, future perspectives challenges fabrication intelligent biofunctional materials also discussed at end expected promote translational development nanomaterials biomedical field.

Language: Английский

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