Journal of the American Chemical Society,
Journal Year:
2021,
Volume and Issue:
143(50), P. 21143 - 21160
Published: Dec. 8, 2021
Fluorescent
organic
dyes
have
been
extensively
used
as
raw
materials
for
the
development
of
versatile
imaging
tools
in
field
biomedicine.
Particularly,
solid-state
fluorophores
(SSOFs)
past
20
years
has
exhibited
an
upward
trend.
In
recent
years,
studies
on
SSOFs
focused
advanced
tools,
such
optical
contrast
agents
and
phototherapy
agents,
biomedical
applications.
However,
practical
application
these
hindered
owing
to
several
limitations.
Thus,
this
Perspective,
we
provided
insights
that
could
aid
researchers
further
develop
overcome
limitations
limited
aqueous
dispersibility,
low
biocompatibility,
uncontrolled
emission.
First,
described
inherent
photophysical
properties
fluorescence
mechanisms
conventional,
aggregation-induced
emissive,
precipitating
with
respect
their
Subsequently,
highlighted
functionalized
bioimaging,
biosensing,
theranostics.
Finally,
elucidated
potential
prospects
current
SSOF-based
associated
Angewandte Chemie International Edition,
Journal Year:
2020,
Volume and Issue:
59(25), P. 9868 - 9886
Published: March 4, 2020
Abstract
The
concept
of
aggregation‐induced
emission
(AIE)
has
opened
new
opportunities
in
many
research
fields.
Motivated
by
the
unique
feature
AIE
fluorogens
(AIEgens),
during
past
decade,
molecular
probes
and
nanoparticle
(NP)
have
been
developed
for
sensing,
imaging
theranostic
applications
with
excellent
performance
outperforming
conventional
fluorescent
probes.
This
Review
summarizes
latest
advancement
NP
their
emerging
biomedical
applications.
Special
focus
is
to
reveal
how
are
evolved
development
multifunctional
AIEgens,
strategies
overcome
limitations
traditional
more
translational
via
fluorescence
imaging,
photoacoustic
image‐guided
photodynamic/photothermal
therapy.
outlook
discusses
challenges
future
AIEgens
advance
field.
Aggregate,
Journal Year:
2020,
Volume and Issue:
1(1), P. 80 - 106
Published: Dec. 1, 2020
Abstract
Theranostics
referring
to
the
ingenious
integration
of
diagnostics
and
therapeutics
has
garnered
tremendous
attention
in
these
years
as
it
provides
a
promising
opportunity
for
modern
personalized
precision
medicine.
By
virtue
good
biocompatibility,
outstanding
fluorescence
property,
easy
processability
functionalization,
promoted
photosensitizing
efficiency,
well
facile
construction
multi‐modality
theranostics,
fluorophores
with
aggregation‐induced
emission
(AIE)
characteristics
exhibit
inexhaustible
vigorous
vitality
field
theranostics.
Numerous
significant
breakthroughs
state‐of‐the‐art
progression
have
been
witnessed
past
few
years.
This
review
highlights
aggregation‐enhanced
superiorities
AIE
luminogens
(AIEgens)
disease
theranostics
mainly
involving
diagnostic
imaging
(fluorescence
room
temperature
phosphorescence),
therapeutic
intervention
(photodynamic
therapy),
feasibility
based
on
experimental
measurements
theoretical
simulations.
Additionally,
latest
advanced
developments
AIEgens
aspect
corresponding
strategies
design
highly
effective
AIE‐active
through
triggering
aggregation
formation
are
comprehensively
summarized.
Moreover,
brief
conclusion
discussion
current
challenges
future
perspectives
this
area
is
further
presented.
Advanced Materials,
Journal Year:
2019,
Volume and Issue:
32(1)
Published: Oct. 3, 2019
Precise
design
of
fluorescent
molecules
with
desired
properties
has
enabled
the
rapid
development
many
research
fields.
Among
different
types
optically
active
materials,
luminogens
aggregation-induced
emission
(AIEgens)
have
attracted
significant
interest
over
past
two
decades.
The
negligible
luminescence
AIEgens
as
a
molecular
species
and
high
brightness
in
aggregate
states
distinguish
them
from
conventional
dyes,
which
galvanized
efforts
to
bring
wide
array
multidisciplinary
applications.
Herein,
useful
principles
emerging
structure-property
relationships
for
precise
toward
desirable
using
concrete
examples
are
revealed.
cutting-edge
applications
their
excellent
performance
enabling
new
directions
biomedical
theranostics,
optoelectronic
devices,
stimuli-responsive
smart
visualization
physical
processes
also
highlighted.
Chemical Science,
Journal Year:
2021,
Volume and Issue:
12(10), P. 3406 - 3426
Published: Jan. 1, 2021
Small-molecule
based
fluorescent
probes
are
increasingly
important
for
the
detection
and
imaging
of
biological
signaling
molecules
due
to
their
simplicity,
high
selectivity
sensitivity,
whilst
being
non-invasive,
suitable
real-time
analysis
living
systems.
With
this
perspective
we
highlight
sensing
mechanisms
including
Förster
resonance
energy
transfer
(FRET),
intramolecular
charge
(ICT),
photoinduced
electron
(PeT),
excited
state
proton
(ESIPT),
aggregation
induced
emission
(AIE)
multiple
modality
fluorescence
approaches
dual/triple
(DSM
or
TSM).
Throughout
remaining
challenges
suggest
potential
directions
development
towards
improved
small-molecule
biosensing.
Chemical Society Reviews,
Journal Year:
2019,
Volume and Issue:
49(1), P. 21 - 31
Published: Dec. 4, 2019
The
results
of
numerous
studies
have
led
to
the
development
supramolecular
(assembled)
organic
substances
for
use
in
biomedical
imaging
as
part
comprehensive
approaches
diagnosis
diseases.
This
review
summarizes
recent
advances
that
been
made
design
and
fabrication
assembled
dyes
fluorescence
photoacoustic
bioimaging.
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(22), P. 12616 - 12655
Published: Jan. 1, 2021
Mechanisms,
recent
advancements
and
perspectives
concerning
nonconventional
luminophores
free
of
classic
conjugates
but
with
intrinsic
photoluminescence
are
discussed.
Aggregate,
Journal Year:
2021,
Volume and Issue:
2(1), P. 95 - 113
Published: Jan. 22, 2021
Abstract
Phototheranostics
that
concurrently
and
complementarily
integrate
real‐time
diagnosis
in
situ
therapeutic
capabilities
one
platform
has
become
the
advancing
edge
of
precision
medicine.
Organic
agents
possess
merits
facile
preparation,
high
purity,
tunable
photophysical
property,
good
biocompatibility,
potential
biodegradability,
which
have
shown
great
promise
for
disease
theranostics.
This
review
summarizes
recent
achievements
organic
phototheranostic
applications,
especially
rationally
utilize
energy
dissipation
pathways
Jablonski
diagram
to
modulate
fluorescence
emission,
photoacoustic/photothermal
production,
photodynamic
processes.
Of
particular
interest
are
systems
exhibiting
huge
differences
aggregate
state
as
compared
with
solution
or
single
molecule
form,
during
intramolecular
motions
play
an
important
role
regulating
properties.
The
advances
from
such
aspect
biomedical
applications
including
high‐resolution
imaging,
activatable
imaging
therapy,
adaptive
theranostics,
image‐guided
surgery,
immunotherapy,
afterglow
discussed.
A
brief
summary
perspective
this
field
also
presented.
We
hope
will
be
helpful
researchers
interested
bioprobe
design
theranostic
inspire
new
insights
into
linkage
between
science
field.
Journal of the American Chemical Society,
Journal Year:
2020,
Volume and Issue:
142(13), P. 6381 - 6389
Published: March 13, 2020
The
recurrence
of
malignant
tumors
is
mostly
caused
by
incompleted
surgical
resection.
Especially,
it
difficult
for
surgeons
to
detect
and
accurately
remove
metastatic
predominantly
using
visual
examination
palpation
owing
the
lack
effective
means
specifically
distinguish
boundary
range
between
normal
tumor
tissues.
Thus,
development
activated
fluorescent
probe
with
superior
tumor-to-normal
(T/N)
tissue
ratios
particularly
urgent
in
clinics.
In
view
CD13/aminopeptidase
N
(APN)
regarded
as
a
cancer-specific
biomarker,
mediating
progression,
invasion,
migration
tumor,
herein,
we
reported
an
APN-responsive
YH-APN
demonstrated
its
application
cancer
cells.
Through
situ
spraying
manner,
(subcutaneous
transplantation
13.86;
hepatic
metastasis,
4.42
6.25;
splenic
4.99)
were
achieved.
More
importantly,
have
ability
image
metastasis
less
than
1
mm
diameter,
highlighting
potential
this
be
used
tool
This
research
may
spur
use
enzyme-activatable
probes
progress
diagnosis
image-guided
surgery
(IGS).
Chemical Reviews,
Journal Year:
2019,
Volume and Issue:
119(23), P. 11819 - 11856
Published: Nov. 1, 2019
Amyloids
are
a
broad
class
of
proteins
and
peptides
that
can
misfold
assemble
into
long
unbranched
fibrils
with
cross-β
conformation.
These
misfolding
aggregation
events
associated
the
onset
variety
human
diseases,
among
them,
Alzheimer's
disease,
Parkinson's
Huntington
disease.
Our
understanding
amyloids
has
been
greatly
supported
by
fluorescent
molecular
probes,
such
as
thioflavin-T,
which
shows
an
increase
in
fluorescence
emission
upon
binding
to
fibrillar
aggregates.
Since
first
application
thioflavin-T
amyloid
studies
nearly
30
years
ago,
many
probes
have
emerged
exhibiting
responses
amyloids,
intensity
changes,
shifts
maxima,
variations
lifetimes,
others.
shed
light
on
topics
including
kinetics
aggregation,
effectiveness
inhibitors,
elucidation
sites
structures,
staining
aggregates
vitro,
ex
vivo,
vivo.
In
this
Review,
we
discuss
design,
properties,
photoactive
used
study
well
challenges
faced
current
techniques,
novel
approaches
emerging
address
these
challenges.
