Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(24)

Published: April 26, 2019

Fluorescence bioimaging affords a vital tool for both researchers and surgeons to molecularly target variety of biological tissues processes. This review focuses on summarizing organic dyes emitting at transparency window termed the near-infrared-II (NIR-II) window, where minimal light interaction with surrounding allows photons travel nearly unperturbed throughout body. NIR-II fluorescence imaging overcomes penetration/contrast bottleneck in visible region, making it remarkable modality early diagnosis cancer highly sensitive tumor surgery. Due their convenient bioconjugation peptides/antibodies, molecular are desirable candidates targeted imaging, significantly overcoming autofluorescence/scattering issues deep tissue imaging. To promote clinical translation bioimaging, advancements high-performance small molecule-derived probes critically important. Here, molecules potential discussed, synthesis chemical structures dyes, optical properties behavior whole body detection surgery, as well microscopy A key perspective direction surgery is also discussed.

Language: Английский

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Molecular Engineering of NIR‐II Fluorophores for Improved Biomedical Detection

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 60(30), P. 16294 - 16308

Published: Aug. 12, 2020

The development of fluorophores for the second near-infrared window (NIR-II, 1000-1700 nm) represents an emerging, significant, and vibrant field in analytic chemistry, chemical biology, biomedical engineering. wavelength, brightness, stability are three crucial factors that determine performance NIR-II fluorophore. Up to now, significant progress has been made fluorescence molecular probes, including synthesis D-A-D D-π-A with improved imaging construction off-on probes ratiometric via energy transfer or structure modification. In this review, we summarize most recent advances engineering design strategies then highlight a selection bioimaging biosensing applications. We also provide perspectives on potential challenges opportunities emerging field.

Language: Английский

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Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics

Chemical Reviews, Journal Year: 2021, Volume and Issue: 122(1), P. 209 - 268

Published: Oct. 19, 2021

In vivo imaging in the second near-infrared window (NIR-II, 1000-1700 nm), which enables us to look deeply into living subjects, is producing marvelous opportunities for biomedical research and clinical applications. Very recently, there has been an upsurge of interdisciplinary studies focusing on developing versatile types inorganic/organic fluorophores that can be used noninvasive NIR-IIa/IIb (NIR-IIa, 1300-1400 nm; NIR-IIb, 1500-1700 nm) with near-zero tissue autofluorescence deeper penetration. This review provides overview reports published date design, properties, molecular imaging, theranostics fluorophores. First, we summarize design concepts up-to-date functional biomaterials, order single-walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare-earth-doped nanoparticles (RENPs), organic (OFs). Then, these novel modalities applications brought by superior fluorescent properties are reviewed. Finally, challenges perspectives future translation, aiming at boosting application progress NIR-IIa NIR-IIb technology highlighted.

Language: Английский

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Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis

Nature Reviews Cardiology, Journal Year: 2021, Volume and Issue: 19(4), P. 228 - 249

Published: Nov. 10, 2021

Nanotechnology could improve our understanding of the pathophysiology atherosclerosis and contribute to development novel diagnostic therapeutic strategies further reduce risk cardiovascular disease. Macrophages have key roles in progression and, therefore, macrophage-associated pathological processes are important targets for both imaging therapies atherosclerosis. In this Review, we highlight efforts past two decades develop techniques therapeutically manipulate macrophages atherosclerotic plaques with use rationally designed nanoparticles. We review latest progress nanoparticle-based modalities that can specifically target macrophages. Using molecular technology, these enable identification advanced assessment efficacy medical interventions. Additionally, provide perspectives on how macrophage-targeting nanoparticles deliver a broad range payloads lesions. These suppress pro-atherogenic macrophage processes, leading improved resolution inflammation stabilization plaques. Finally, propose future opportunities solutions challenges area purpose accelerating clinical translation nanomedicine treatment vascular

Language: Английский

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J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: April 22, 2021

Abstract J-aggregation is an efficient strategy for the development of fluorescent imaging agents in second near-infrared window. However, design J-aggregates challenging due to lack suitable dyes. Herein, we report meso -[2.2]paracyclophanyl-3,5-bis- N , -dimethylaminostyrl BODIPY (PCP-BDP2) as example dye with induced fluorescence. PCP-BDP2 shows emission maximum at 1010 nm state. Mechanism studies reveal that steric and conjugation effect PCP group on play key roles behavior photophysical properties tuning. Notably, can be utilized lymph node fluorescence-guided surgery nude mouse, which demonstrates their potential clinical application. This study alternate platform developing agents.

Language: Английский

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Semiconducting Polymer Dots with Dual‐Enhanced NIR‐IIa Fluorescence for Through‐Skull Mouse‐Brain Imaging

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 59(9), P. 3691 - 3698

Published: Dec. 11, 2019

Fluorescence probes in the NIR-IIa region show drastically improved imaging owing to reduced photon scattering and autofluorescence biological tissues. Now, polymer dots (Pdots) are developed with a dual fluorescence enhancement mechanism. First, aggregation induced emission of phenothiazine was used reduce nonradiative decay pathways polymers condensed states. Second, quenching minimized by different levels steric hindrance further boost fluorescence. The resulting Pdots displayed QY ca. 1.7 % aqueous solution, suggesting an 21 times comparison original tetrahydrofuran (THF) solution. Small-animal using exhibited remarkable improvement penetration depth signal background ratio, as confirmed through-skull through-scalp fluorescent cerebral vasculature live mice.

Language: Английский

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Molecular Fluorophores for Deep-Tissue Bioimaging

ACS Central Science, Journal Year: 2020, Volume and Issue: 6(8), P. 1302 - 1316

Published: July 23, 2020

Fluorescence imaging has made tremendous inroads toward understanding the complexity of biological systems, but in vivo deep-tissue remains a great challenge due to optical opacity tissue. Recent improvements laser and detector manufacturing have allowed expansion nonlinear linear fluorescence underexplored "tissue-transparent" second near-infrared (NIR-II; 1000–1700 nm) window, opening up new opportunities for access deep inside opaque Molecular fluorophores historically played major role bioimaging. It is increasingly important design molecular fully unlock potential NIR-II techniques. In this outlook, we give an overview novel developed bioimaging past five years discuss their pros cons applications. Guidelines designing with desirable properties are also provided.

Language: Английский

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Rational Design of Near-Infrared-II Organic Molecular Dyes for Bioimaging and Biosensing

ACS Materials Letters, Journal Year: 2020, Volume and Issue: 2(8), P. 905 - 917

Published: June 18, 2020

In the past decade, fluorescence bioimaging in second near-infrared (NIR-II, 1000–1700 nm) window has shown great potential both fundamental research and preclinical diagnosis prognosis, owing to high resolution at deep penetration decreasing light absorption scattering. Compared inorganic contrast agents, NIR-II organic dyes are more promising for biological application due low molecular mass, good biocompatibility, flexible design. this review, current chemical structures applications of (polymethine donor–acceptor–donor dyes) discussed. addition, rational design strategies dyes, including conjugated chain length, length alternations, charge transfer between terminal groups, rigid plane structure, other factors, summarized. This review may provide guidance further development novel biosensing.

Language: Английский

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Chemical Design of Activatable Photoacoustic Probes for Precise Biomedical Applications

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(6), P. 6850 - 6918

Published: March 2, 2022

Photoacoustic (PA) imaging technology, a three-dimensional hybrid modality that integrates the advantage of optical and acoustic imaging, has great application prospects in molecular due to its high depth resolution. To endow PA with ability for real-time visualization precise biomedical diagnosis, numerous activatable probes which can specifically alter their intensities upon reacting targets or biological events interest have been developed. This review highlights recent developments applications including detection biotargets events. First, generation mechanism signals will be given, followed by brief introduction contrast agents used probe design. Then we particularly summarize general design principles alteration strategies developing probes. Furthermore, give detailed discussion living systems. At last, current challenges outlooks future discussed. We hope this stimulate new ideas explore potentials future.

Language: Английский

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Organic dye assemblies with aggregation‐induced photophysical changes and their bio‐applications

Aggregate, Journal Year: 2021, Volume and Issue: 2(4)

Published: Feb. 23, 2021

Abstract Phototheranostics provide a safe, effective, and noninvasive way for the diagnosis treatment of contemporary diseases, organic dyes play vital role. For example, chemical modification endowed with powerful reactive oxygen species or heat generation ability, favoring photodynamic therapy photoacoustic (PA) imaging guided photothermal (PTT) serious diseases. Therefore, photophysical properties manipulation has become focus in current dye chemistry research. The development aggregate science made great effort to solve this problem. In recent years, large number studies have focused on molecular aggregation behavior its effect performance. most famous example is discovery aggregation‐induced emission (AIE) phenomenon. Based AIE theory, more theories revealing relationship between were proposed elucidated. property changes caused by unique discipline, guiding material science. With help self‐assembly, controllable can be realized, stable nano‐theranostic reagents obtained. Furthermore, constructing assemblies various will greatly reduce cost theranostic reagents, thus, expanding biomedical applications dyes. review focuses characteristic their biological including, fluorescence/phosphorescence/PA as well PTT. This guidance design dyes, methods, construction multifunctional phototheranostic reagents.

Language: Английский

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