Through-skull fluorescence imaging of the brain in a new near-infrared window

Nature Photonics, Journal Year: 2014, Volume and Issue: 8(9), P. 723 - 730

Published: Aug. 1, 2014

Language: Английский

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Diaschisis: past, present, future

Brain, Journal Year: 2014, Volume and Issue: 137(9), P. 2408 - 2422

Published: May 28, 2014

After a century of false hopes, recent studies have placed the concept diaschisis at centre understanding brain function. Originally, term 'diaschisis' was coined by von Monakow in 1914 to describe neurophysiological changes that occur distant focal lesion. In following decades, this triggered widespread clinical interest an attempt symptoms and signs lesion could not fully explain. However, first imaging studies, late 1970s, only partially confirmed significance diaschisis. Focal cortical areas (i.e. diaschisis) contributed deficits after subcortical but rarely lesions. For reason, progressively disappeared from mainstream research neurosciences. Recent evidence has unexpectedly revitalized notion. The development new techniques allows better complexity organization. It is now possible reliably investigate type defined as structural functional connectivity between connectional diaschisis). As opposed diaschisis, focusing on determined networks, seems relate more consistently findings. This particularly true stroke motor attentional networks. Furthermore, normalization remote these networks relates recovery. future, role systematic approach be considered. First, emerging electrophysiological should used precisely map selectively model lesions human animals studies. Second, must applied determine impact representations example, evaluation structure connectome so far mainly been tested modelization These assessed patients suffering connectomal Finally, major significance, non-focal target therapeutic strategies. Neuromodulation using transcranial magnetic stimulation one most promising techniques. when last step will successful gain all respectability obtained decades research.

Language: Английский

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High-speed label-free functional photoacoustic microscopy of mouse brain in action

Nature Methods, Journal Year: 2015, Volume and Issue: 12(5), P. 407 - 410

Published: March 30, 2015

Language: Английский

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The smallest stroke: occlusion of one penetrating vessel leads to infarction and a cognitive deficit

Nature Neuroscience, Journal Year: 2012, Volume and Issue: 16(1), P. 55 - 63

Published: Dec. 16, 2012

Language: Английский

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Entrainment of Arteriole Vasomotor Fluctuations by Neural Activity Is a Basis of Blood-Oxygenation-Level-Dependent “Resting-State” Connectivity

Neuron, Journal Year: 2017, Volume and Issue: 96(4), P. 936 - 948.e3

Published: Oct. 26, 2017

Language: Английский

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Pericyte structure and distribution in the cerebral cortex revealed by high-resolution imaging of transgenic mice

Neurophotonics, Journal Year: 2015, Volume and Issue: 2(4), P. 041402 - 041402

Published: May 27, 2015

Pericytes are essential for normal brain function, but many aspects of their physiology remain enigmatic due to a lack tools genetically target this cell population. Here, we characterize pericytes using two existing Cre-recombinase driver mouse lines that can serve distinct purposes in cerebrovascular research. One line expresses an inducible version Cre under the NG2 proteoglycan promoter, which provides sparse labeling necessary define morphology single cells. These mice reveal structural differences between adjacent arterioles versus those broadly distributed capillary bed may underlie differential roles control vessel caliber. A second constitutively platelet-derived growth factor receptor β promoter and continuous, highly specific near-complete myocytes along entire cerebrovasculature. This three-dimensional view pericyte distribution cortical angioarchitecture following optical clearing tissue. In combination with recent reporter expression optogenetic actuators activity-sensitive probes, these be key studying biology intact brain.

Language: Английский

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Brain capillary pericytes exert a substantial but slow influence on blood flow

Nature Neuroscience, Journal Year: 2021, Volume and Issue: 24(5), P. 633 - 645

Published: Feb. 18, 2021

Language: Английский

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Functional ultrasound imaging of the brain: theory and basic principles

IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control, Journal Year: 2013, Volume and Issue: 60(3), P. 492 - 506

Published: March 1, 2013

Hemodynamic changes in the brain are often used as surrogates of neuronal activity to infer loci activity. A major limitation conventional Doppler ultrasound for imaging these is that it not sensitive enough detect blood flow small vessels where part hemodynamic response occurs. Here, we present a μDoppler method able and map cerebral volume (CBV) over entire with an important increase sensitivity. This based on at ultrafast frame rate (1 kHz) using compounded plane wave emissions. theoretical model demonstrates gain sensitivity due combination 1) high signal-to-noise ratio gray scale images, resulting from synthetic compounding backscattered echoes; 2) extensive signal averaging enabled by temporal sampling rates. performed vivo trepanned rats without use contrast agents. The images reveal detailed maps rat vascularization acquisition time short 320 ms per slice. new basis real-time functional (fUS) brain.

Language: Английский

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Thrombo-inflammation in acute ischaemic stroke — implications for treatment

Nature Reviews Neurology, Journal Year: 2019, Volume and Issue: 15(8), P. 473 - 481

Published: July 1, 2019

Language: Английский

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Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity

Nature Neuroscience, Journal Year: 2016, Volume and Issue: 19(3), P. 432 - 442

Published: Feb. 8, 2016

Language: Английский

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