Mechanobiology of collective cell behaviours

Nature Reviews Molecular Cell Biology, Journal Year: 2017, Volume and Issue: 18(12), P. 743 - 757

Published: Nov. 8, 2017

Language: Английский

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Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

Nature, Journal Year: 2019, Volume and Issue: 573(7772), P. 69 - 74

Published: Aug. 21, 2019

Language: Английский

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Piezos thrive under pressure: mechanically activated ion channels in health and disease

Nature Reviews Molecular Cell Biology, Journal Year: 2017, Volume and Issue: 18(12), P. 771 - 783

Published: Oct. 4, 2017

Language: Английский

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Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

Cell, Journal Year: 2020, Volume and Issue: 181(4), P. 800 - 817.e22

Published: April 16, 2020

Tissue homeostasis requires maintenance of functional integrity under stress. A central source stress is mechanical force that acts on cells, their nuclei, and chromatin, but how the genome protected against unclear. We show stretch deforms nucleus, which cells initially counteract via a calcium-dependent nuclear softening driven by loss H3K9me3-marked heterochromatin. The resulting changes in chromatin rheology architecture are required to insulate genetic material from force. Failure mount this mechanoresponse results DNA damage. Persistent, high-amplitude induces supracellular alignment tissue redistribute energy before it reaches nucleus. This tissue-scale mechanoadaptation functions through separate pathway mediated cell-cell contacts allows cells/tissues switch off mechanotransduction restore initial state. Our work identifies an unconventional role altering its own state maintain response deformation.

Language: Английский

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Tensile Forces and Mechanotransduction at Cell–Cell Junctions

Current Biology, Journal Year: 2018, Volume and Issue: 28(8), P. R445 - R457

Published: April 1, 2018

Language: Английский

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Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: Jan. 15, 2020

Abstract Wolff’s law and the Utah Paradigm of skeletal physiology state that bone architecture adapts to mechanical loads. These models predict existence a mechanostat links strain induced by forces remodeling. However, how influences remodeling remains elusive. Here, we find Piezo1 deficiency in osteoblastic cells leads loss mass spontaneous fractures with increased resorption. Furthermore, -deficient mice are resistant further resorption hind limb unloading, demonstrating PIEZO1 can affect osteoblast-osteoclast crosstalk response forces. At mechanistic level, loads, controls YAP-dependent expression type II IX collagens. In turn, these collagen isoforms regulate osteoclast differentiation. Taken together, our data identify as major mechanosensor tunes homeostasis.

Language: Английский

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Feeling Stress: The Mechanics of Cancer Progression and Aggression

Frontiers in Cell and Developmental Biology, Journal Year: 2018, Volume and Issue: 6

Published: Feb. 28, 2018

The tumor microenvironment is a dynamic landscape in which the physical and mechanical properties evolve dramatically throughout cancer progression. These changes are driven by enhanced cell contractility expansion of growing mass, as well through alterations to material surrounding extracellular matrix (ECM). Consequently, cells exposed number different inputs including cell-cell cell-ECM tension, compression stress, interstitial fluid pressure shear stress. Oncogenes engage signaling pathways that activated response thereby reworking cell’s intrinsic exogenous stimuli, enhancing intracellular tension via elevated actomyosin contraction, influencing ECM stiffness tissue morphology. In addition altering their remodeling microenvironment, actively respond these perturbations phenotypically modification gene expression. Herein, we present description promote progression aggression, discuss interrelationship highlight emerging therapeutic strategies alleviate stresses driving malignancy.

Language: Английский

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The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior

Science, Journal Year: 2020, Volume and Issue: 370(6514)

Published: Oct. 16, 2020

The nucleus makes the rules Single cells continuously experience and react to mechanical challenges in three-dimensional tissues. Spatial constraints dense tissues, physical activity, injury all impose changes cell shape. How can measure shape deformations ensure correct tissue development homeostasis remains largely unknown (see Perspective by Shen Niethammer). Working independently, Venturini et al. Lomakin now show that act as an intracellular ruler cellular variations. nuclear envelope provides a gauge of deformation activates mechanotransduction pathway controls actomyosin contractility migration plasticity. thereby allows adapt their behavior local microenvironment. Science , this issue p. eaba2644 eaba2894 ; see also 295

Language: Английский

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Circuit Design Features of a Stable Two-Cell System

Cell, Journal Year: 2018, Volume and Issue: 172(4), P. 744 - 757.e17

Published: Feb. 1, 2018

Language: Английский

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A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression

Neuron, Journal Year: 2018, Volume and Issue: 100(4), P. 799 - 815.e7

Published: Oct. 18, 2018

Language: Английский

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