International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(4), P. 1775 - 1775
Published: Feb. 19, 2025
Quorum
quenchers
are
emerging
as
an
alternative
to
conventional
antimicrobials,
since
they
hinder
the
development
of
virulence
or
resistance
mechanisms
but
without
killing
microorganisms,
thus,
reducing
risk
antimicrobial
resistance.
Many
quorum
analogs
natural
quorum-sensing
signaling
molecules
autoinducers.
Thus,
different
N-acylhomoserine
lactones
(AHLs)
have
been
reported
for
controlling
production
biofilms
in
Gram-negative
pathogens.
Herein
we
report
preparation
AHL
with
a
variety
N-substituents
just
two
steps
from
readily
available
N-substituted
hydroxyproline
esters.
The
substrates
underwent
oxidative
radical
scission
pyrrolidine
ring.
resulting
β-aminoaldehyde
reduction
and
situ
cyclization
give
homoserine
lactones,
N-
N,N-substituted
amino
derivatives
high
optical
purity.
libraries
were
screened
inhibition
violacein
Chromobacterium
violaceum,
pathogen.
For
first
time,
N,N-disubstituted
studied.
Several
N-sulfonyl
derivatives,
one
carbamoyl,
N-alkyl-N-sulfonyl
lactone
displayed
promising
inhibitory
activity.
Moreover,
did
not
display
microbicide
action
against
S.
aureus,
C.
jejuni,
enterica,
P.
aeruginosa,
albicans,
confirming
pure
QQ
determination
structure–activity
relationships
silico
ADME
studies
also
reported,
which
valuable
design
next
generations
agents.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2655 - 2655
Published: Feb. 24, 2024
One
of
the
key
mechanisms
enabling
bacterial
cells
to
create
biofilms
and
regulate
crucial
life
functions
in
a
global
highly
synchronized
way
is
communication
system
called
quorum
sensing
(QS).
QS
cell-to-cell
process
that
depends
on
population
density
mediated
by
small
signalling
molecules
autoinducers
(AIs).
In
bacteria,
controls
biofilm
formation
through
regulation
gene
expression
involved
extracellular
polymeric
matrix
(EPS)
synthesis,
virulence
factor
production,
stress
tolerance
metabolic
adaptation.
Forming
one
antimicrobial
resistance
(AMR).
A
common
feature
human
pathogens
ability
form
biofilm,
which
poses
serious
medical
issue
due
their
high
susceptibility
traditional
antibiotics.
Because
associated
with
formation,
there
belief
inhibition
activity
quenching
(QQ)
may
provide
alternative
therapeutic
methods
for
treating
microbial
infections.
This
review
summarises
recent
progress
research,
focusing
biofilms,
especially
those
formed
pathogenic
become
resistant
antibiotic
treatment.
Subsequently,
potential
approach
highlighting
innovative
non-antibiotic
strategies
control
AMR
bacteria
has
been
discussed.
Pharmacological Research - Modern Chinese Medicine,
Journal Year:
2023,
Volume and Issue:
9, P. 100323 - 100323
Published: Nov. 4, 2023
Allium
sativum,
the
bulbous
perennial
plant
of
Alliaceae
family
has
been
utilized
as
a
very
valuable
remedy
in
management
numerous
diseases
even
from
time
immemorial.
The
exhibits
antimicrobial
activities
over
wide
range
microorganisms
like
parasites,
fungi,
virus
and
other
pathogens.
This
broad-
spectrum
activity
coupled
with
low
toxicity
sativum
are
an
attraction
to
scientists
thus
it
vastly
employed
therapeutic
cure
contemporary
society.
properties
(antibacterial,
antiviral,
fungicidal,
anti-cardiovascular
disease,
anticancer,
antidiabetic,
anti-blood
pressure,
antiatherosclerosis,
antirheumatic,
hyperlipidemia)
linked
sulphur
compounds
contains
(diallyl
disulfide,
allicin,
diallyl
trisulfide,
ajoene's,
vinyl-dithiin,
micronutrient
selenium
S-allylcystein.
review
considers
some
contained
mechanisms
by
which
they
elicit
their
biological
actions.
journals
for
this
paper
were
retrieved
prominent
database
sources
Academia.edu
(https://www.academia.edu),
PubMed
(https://pubmed.ncbi.nlm.nih.gov/)
Web
science
(https://access.clarivate.com).
Both
medical
headings
free
text
keywords
search
"biological
allicin",
"biosynthesis
garlic",
"sulphur
"mechanism
action
antibacterial
ajoene",
"S-allylcystein
neuroprotection
vinvyl-dithiin",
"anticancer
actions
dially
disulfide",
mechanism
anti-quorum
sensing
ajoene,
antihyperlipidemic
anti-platelet
ajoene
related
information
journals.
many
properties;
antibacterial,
neuroprotection,
lipid
metabolism,
glucose
hyperlipidemia),
these
result
S-allylcystein)
contains.
Within
paper,
containing
phytonutrients
namely;
S-allylcystein,
vinvyl-dithiin,
trisulfide
carry
out
considered.
pharmaceutical
food
industries
have
harnessed
phytochemicals
manufacturing
both
wellness
products.
Should
more
research
be
carried
on
safe
effective
doses
can
authenticated
so
that
safely
included
pathologies.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(15), P. 3466 - 3466
Published: July 24, 2024
Antibiotic
resistance
is
a
major
problem
and
global
health
concern.
In
total,
there
are
16
million
deaths
yearly
from
infectious
diseases,
at
least
65%
of
diseases
caused
by
microbial
communities
that
proliferate
through
the
formation
biofilms.
overuse
has
resulted
in
evolution
multidrug-resistant
(MDR)
strains.
As
result,
now
much
more
interest
non-antibiotic
therapies
for
bacterial
infections.
Among
these
revolutionary,
non-traditional
medications
quorum
sensing
inhibitors
(QSIs).
Bacterial
cell-to-cell
communication
known
as
(QS),
it
mediated
tiny
diffusible
signaling
molecules
autoinducers
(AIs).
QS
dependent
on
density
population.
used
Gram-negative
Gram-positive
bacteria
to
control
wide
range
processes;
both
scenarios,
entails
synthesis,
identification,
reaction
chemicals,
also
auto-inducers.
Since
usual
processes
regulated
expression
virulence
factors
creation
biofilms,
being
investigated
an
alternative
solution
antibiotic
resistance.
Consequently,
use
QS-inhibiting
agents,
such
QSIs
quenching
(QQ)
enzymes,
interfere
with
seems
like
good
strategy
prevent
This
review
sheds
light
inhibition
mechanisms
discusses
how
using
this
approach
can
aid
winning
battle
against
resistant
bacteria.
Journal of Chemistry,
Journal Year:
2025,
Volume and Issue:
2025(1)
Published: Jan. 1, 2025
The
formation
of
biofilms
occurs
due
to
a
group
bacteria
gathering
together.
increasing
cell
density
will
stimulate
chemical
signals
for
communicate
through
quorum
sensing
system.
Quorum
plays
role
competition,
virulence,
resistance,
and
pathogenesis.
produces
signaling
response
called
as
autoinducers.
Gram‐negative
produce
N
‐acyl‐
L
‐homoserine
lactones
autoinducer,
while
in
Gram‐positive
autoinducing
peptides.
By
looking
at
responses
bacterial
pathogenesis
the
study
natural
antibiotic
agents
became
particular
concern
researchers.
This
review
summarizes
systems
acting
on
bacteria,
biofilm
by
pathogenic
potential
use
medicinal
plants
anti–quorum
reviewed
vitro
silico.
extracts
from
leaves,
fruits,
flowers,
stems,
isolated
compounds
some
types
essential
oils
has
been
successfully
tested
have
activity.
Veterinary Research,
Journal Year:
2025,
Volume and Issue:
56(1)
Published: Feb. 4, 2025
Abstract
The
biofilm
acts
as
a
protective
layer
for
Streptococcus
suis
(
S.
),
contributing
to
the
development
of
drug
resistance
and
chronic
infections.
Autoinducer
2
(AI-2)
quorum
sensing
represents
primary
regulatory
pathway
governing
formation
in
.
Consequently,
targeting
AI-2
inhibit
promising
strategy
preventing
managing
infections
caused
by
This
study
established
small
natural
product
library
integrating
commercial
molecules
with
Chinese
herbal
medicine
molecules.
two
products,
salvianolic
acid
A
(SAA)
rhapontin
(RH),
which
target
via
sensing,
were
identified.
SAA
RH
synthesis
through
noncompetitive
competitive
binding
S-ribosylhomocysteinase
(LuxS).
By
inhibiting
these
compounds
modulate
expression
adhesion
genes
extracellular
polysaccharides
(EPS),
reducing
ability
ultimately
formation.
Using
LC‒MS/MS,
we
further
analysed
impact
on
metabolic
activity
,
revealing
potential
medicinal
value
compounds.
Finally,
efficacy
against
infection
was
validated
Galleria
mellonella
larvae,
confirming
their
significant
anti-infection
effects.
Archives of Microbiology,
Journal Year:
2025,
Volume and Issue:
207(3)
Published: Feb. 8, 2025
The
LasR
quorum
sensing
system
regulates
the
virulence
factors
of
Pseudomonas
aeruginosa,
a
multi-drug
resistant
pathogen.
Mangiferin
and
related
compounds
have
been
found
to
modulate
this
as
determined
by
in
silico
vitro
experimental
procedures.
ZINCPharmer
was
used
compile
library
over
1000
metabolites
that
were
screened
top
five
based
on
shared
pharmacophores
drug-like
properties
with
mangiferin.
Molecular
docking
molecular
dynamics
simulation
(140
ns)
showed
ZINC
E
(-
55.64
±
2.93
kcal/mol)
D
54.51
2.82
had
significantly
lower
binding
free
energy
compared
mangiferin-LasR
42.24
3.94
reference
standard
(azithromycin-LasR
40.01
6.15
kcal/mol).
(95.16%)
competed
favorably
mangiferin
(95.77%)
potential
QS
modulators
at
sub-minimum
inhibitory
concentrations
relative
(85.07%)
azithromycin
(85.79%).
These
observations
suggest
lead
drug
candidates
for
P.
aeruginosa
infection
management.
Critical Reviews in Microbiology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 15
Published: Feb. 20, 2025
Quorum
sensing
(QS)
is
a
bacterial
communication
method
closely
linked
with
population
density
and
regulates
biofilm
formation
the
secretion
of
virulence
factors
through
release,
recognition,
prompt
response
to
small
molecule
signals.
At
low
cell
density,
each
bacterium
produces
concentration
QS
signals
that
diffuse
or
are
actively
transported
into
external
environment.
The
accumulated
in
environment
reach
threshold
when
attains
certain
enabling
effective
recognition
interaction
their
receptors.
This
leads
coordinated
gene
expression
various
biological
activities
across
population.
Targeting
system
presents
promising
strategy
hinder
factor
secretion,
providing
potential
approach
control
growth
reproduction.
study
aims
analyze
intercellular
mechanisms
quorum
quenching
(QQ),
which
focuses
on
disrupting
signal
molecules
keep
below
preventing
specific
pathogenic
factors.
applications
QQ
different
fields
also
reviewed,
underscoring
its
as
novel
treatment
for
infections.
FEMS Microbiology Ecology,
Journal Year:
2024,
Volume and Issue:
100(6)
Published: May 14, 2024
Abstract
Eukaryotic
organisms
coevolved
with
microbes
from
the
environment
forming
holobiotic
meta-genomic
units.
Members
of
host-associated
microbiomes
have
commensalic,
beneficial/symbiotic,
or
pathogenic
phenotypes.
More
than
100
years
ago,
Lorenz
Hiltner,
pioneer
soil
microbiology,
introduced
term
‘Rhizosphere’
to
characterize
observation
that
a
high
density
saprophytic,
beneficial,
and
are
attracted
by
root
exudates.
The
balance
between
these
types
decide
about
health
host.
Nowadays
we
know,
for
interaction
all
eukaryotic
hosts
similar
principles
processes
cooperative
competitive
functions
in
action.
Small
diffusible
molecules
like
(phyto)hormones,
volatiles
quorum
sensing
signals
examples
mediators
interspecies
cross-kingdom
interactions.
Quorum
bacteria
is
mediated
different
autoinducible
metabolites
density-dependent
manner.
In
this
perspective
publication,
role
QS-related
activities
will
be
discussed
focussing
mostly
on
N-acyl-homoserine
lactones
(AHL).
It
also
considered
some
cases
very
close
phylogenetic
relations
exist
plant
beneficial
opportunistic
human
bacteria.
Based
genome
system-targeted
new
understanding,
sociomicrobiological
solutions
possible
biocontrol
diseases
improvement
hosts.
