Targeting the gut microbiota for cancer therapy

Nature reviews. Cancer, Journal Year: 2022, Volume and Issue: 22(12), P. 703 - 722

Published: Oct. 17, 2022

Language: Английский

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Bacterial exopolysaccharides as emerging bioactive macromolecules: from fundamentals to applications

Research in Microbiology, Journal Year: 2022, Volume and Issue: 174(4), P. 104024 - 104024

Published: Dec. 30, 2022

Language: Английский

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Neuromicrobiology, an emerging neurometabolic facet of the gut microbiome?

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Jan. 17, 2023

The concept of the gut microbiome is emerging as a metabolic interactome influenced by diet, xenobiotics, genetics, and other environmental factors that affect host’s absorption nutrients, metabolism, immune system. Beyond nutrient digestion production, also functions personalized polypharmacy, where bioactive metabolites our microbes excrete or conjugate may reach systemic circulation impact all organs, including brain. Appreciable evidence shows microbiota produce diverse neuroactive metabolites, particularly neurotransmitters (and their precursors), stimulating local nervous system (i.e., enteric vagus nerves) affecting brain function cognition. Several studies have demonstrated correlations between central sparking an exciting new research field, neuromicrobiology. Microbiome-targeted interventions are seen promising adjunctive treatments (pre-, pro-, post-, synbiotics), but mechanisms underlying host-microbiome interactions yet to be established, thus preventing informed evidence-based therapeutic applications. In this paper, we review current state knowledge for each major classes microbial emphasizing biological effects on microbiome, environment, Also, discuss biosynthesis, absorption, transport microbiota-derived implication in mental disorders.

Language: Английский

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Fish disease and intestinal microbiota: A close and indivisible relationship

Reviews in Aquaculture, Journal Year: 2022, Volume and Issue: 15(2), P. 820 - 839

Published: Nov. 8, 2022

Abstract The gut microbiota is currently one of the most studied ‘organs’ in animals, and fish are no exception. A complex diversity microbes, including bacteria, archaea, yeast fungus, constitute microbiota, creating a interaction with their host accomplishing multiple beneficial functions, such as food digestion, nutrient absorption, immune system, endocrine stress response. microbiota–pathogen protects by mounting colonization resistance, competing for nutrients space. Changes balance community could affect structure homeostasis, inducing dysbiosis. In addition, invading pathogens can induce dysbiosis evading host's defence barriers, acquiring from host, using metabolites produced producing toxins. this regard, understanding interactions within essential to prevent pathogen establishment host. Hence, review describes close indivisible relationships between that lead disease.

Language: Английский

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It is the time for quorum sensing inhibition as alternative strategy of antimicrobial therapy

Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)

Published: June 14, 2023

Abstract Multiple drug resistance poses a significant threat to public health worldwide, with substantial increase in morbidity and mortality rates. Consequently, searching for novel strategies control microbial pathogenicity is necessary. With the aid of auto-inducers (AIs), quorum sensing (QS) regulates bacterial virulence factors through cell-to-cell signaling networks. AIs are small molecules produced during stationary phase. When cultures reach certain level growth, these regulate expression bound genes by acting as mirrors that reflect inoculum density. Gram-positive bacteria use peptide derivatives molecules, whereas Gram-negative fatty acid derivatives, majority can both types modulate target gene. Numerous natural synthetic QS inhibitors (QSIs) have been developed reduce pathogenesis. Applications QSI vital human health, well fisheries aquaculture, agriculture, water treatment.

Language: Английский

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Molecular Aspects of the Functioning of Pathogenic Bacteria Biofilm Based on Quorum Sensing (QS) Signal-Response System and Innovative Non-Antibiotic Strategies for Their Elimination

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2655 - 2655

Published: Feb. 24, 2024

One of the key mechanisms enabling bacterial cells to create biofilms and regulate crucial life functions in a global highly synchronized way is communication system called quorum sensing (QS). QS cell-to-cell process that depends on population density mediated by small signalling molecules autoinducers (AIs). In bacteria, controls biofilm formation through regulation gene expression involved extracellular polymeric matrix (EPS) synthesis, virulence factor production, stress tolerance metabolic adaptation. Forming one antimicrobial resistance (AMR). A common feature human pathogens ability form biofilm, which poses serious medical issue due their high susceptibility traditional antibiotics. Because associated with formation, there belief inhibition activity quenching (QQ) may provide alternative therapeutic methods for treating microbial infections. This review summarises recent progress research, focusing biofilms, especially those formed pathogenic become resistant antibiotic treatment. Subsequently, potential approach highlighting innovative non-antibiotic strategies control AMR bacteria has been discussed.

Language: Английский

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Exploring the antivirulence potential of phenolic compounds to inhibit quorum sensing in Pseudomonas aeruginosa

World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(2)

Published: Jan. 11, 2025

Language: Английский

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Metal-Based Approaches for the Fight against Antimicrobial Resistance: Mechanisms, Opportunities, and Challenges

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

The rapid emergency and spread of antimicrobial-resistant (AMR) bacteria the lack new antibiotics being developed pose serious threats to global healthcare system. Therefore, development more effective therapies overcome AMR is highly desirable. Metal ions have a long history serving as antimicrobial agents, metal-based compounds are now attracting interest from scientific communities in fight against owing their unique mechanism. Moreover, they may also serve antibiotic adjuvants enhance efficacy clinically used antibiotics. In this perspective, we highlight important showcase studies last 10 years on strategies crisis. Specifically, categorize these metallo-antimicrobials into five classes based modes action (i.e., metallo-enzymes metal-binding enzyme inhibitors, membrane perturbants, uptake/efflux system inhibitors/regulators, persisters oxidative stress inducers). significant advantages over traditional lie multitargeted mechanisms, which render less likelihood generate resistance. However, notice that such raise concern potential side effects low selectivity toward pathogens host, appears be biggest obstacle for downstream translational research. We anticipate combination therapy through repurposing (metallo)drugs with optimization absorption route formulation achieve target-oriented delivery will powerful way combat AMR. Despite challenges, hold great opportunities therapeutic intervention infection by resistant bacteria.

Language: Английский

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Efflux pumps and microbial biofilm formation

Infection Genetics and Evolution, Journal Year: 2023, Volume and Issue: 112, P. 105459 - 105459

Published: June 2, 2023

Biofilm-related infections are resistant forms of pathogens that regarded as a medical problem, particularly due to the spread multiple drug resistance. One factors associated with biofilm resistance is presence various types efflux pumps in bacteria. Efflux also play role formation by influencing Physical-chemical interactions, mobility, gene regulation, quorum sensing (QS), extracellular polymeric substances (EPS), and toxic compound extrusion. According findings studies based on pump expression analysis, their anatomical position within will differ depending stage, encoding level, type concentration substrate. In some cases, function can overlap each other, so it seems necessary accurate identify biofilm-forming bacteria along this process. Such help choose treatment strategy, at least combination antibiotics. Furthermore, if goal an manipulation, we should not limit inhibition.

Language: Английский

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An updated overview on the relationship between human gut microbiome dysbiosis and psychiatric and psychological disorders

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2023, Volume and Issue: 128, P. 110861 - 110861

Published: Sept. 9, 2023

There is a lot of evidence establishing that nervous system development related to the composition and functions gut microbiome. In addition, central (CNS) controls imbalance intestinal microbiota, constituting bidirectional communication system. At present, various gut-brain crosstalk routes have been described, including immune, endocrine neural circuits via vagal pathway. Several empirical data associated microbiota alterations (dysbiosis) with neuropsychiatric diseases, such as Alzheimer's disease, autism Parkinson's other psychological disorders, like anxiety depression. Fecal transplantation (FMT) therapy has shown can transfer behavioral features recipient animals, which provides strong establish causal-effect relationship. Interventions, based on prebiotics, probiotics or synbiotics, demonstrated an important influence neurological disorders by synthesis neuroactive compounds interact regulation inflammatory processes. Further research needed demonstrate dysbiosis psychiatric how microbiota-based interventions may be used potential therapeutic tools.

Language: Английский

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