Chronic inflammation in the etiology of disease across the life span

Nature Medicine, Journal Year: 2019, Volume and Issue: 25(12), P. 1822 - 1832

Published: Dec. 1, 2019

Language: Английский

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Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

Nature Reviews Cardiology, Journal Year: 2018, Volume and Issue: 15(9), P. 505 - 522

Published: July 31, 2018

Language: Английский

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The inflammatory pathogenesis of colorectal cancer

Nature reviews. Immunology, Journal Year: 2021, Volume and Issue: 21(10), P. 653 - 667

Published: April 28, 2021

Language: Английский

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Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome

Gut, Journal Year: 2021, Volume and Issue: 70(7), P. 1287 - 1298

Published: April 2, 2021

The microbiome directly affects the balance of pro-inflammatory and anti-inflammatory responses in gut. As microbes thrive on dietary substrates, question arises whether we can nourish an gut ecosystem. We aim to unravel interactions between diet, microbiota their functional ability induce intestinal inflammation.We investigated relation 173 factors 1425 individuals spanning four cohorts: Crohn's disease, ulcerative colitis, irritable bowel syndrome general population. Shotgun metagenomic sequencing was performed profile microbial composition function. Dietary intake assessed through food frequency questionnaires. unsupervised clustering identify patterns clusters. Associations diet features were explored per cohort, followed by a meta-analysis heterogeneity estimation.We identified 38 associations Moreover, 61 individual foods nutrients associated with species 249 metabolic pathways across healthy patients IBS, disease UC (false discovery rate<0.05). Processed animal-derived consistently higher abundances Firmicutes, Ruminococcus Blautia genus endotoxin synthesis pathways. opposite found for plant fish, which positively short-chain fatty acid-producing commensals nutrient metabolism.We that correlate groups bacteria shared roles both, health disease. specific known infer mucosal protection effects. propose mechanisms inflammatory as rationale future intervention studies.

Language: Английский

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Engineering of a Nanosized Biocatalyst for Combined Tumor Starvation and Low-Temperature Photothermal Therapy

ACS Nano, Journal Year: 2018, Volume and Issue: 12(3), P. 2858 - 2872

Published: March 6, 2018

Tumor hypoxia is one of the major challenges for treatment tumors, as it may negatively affect efficacy various anticancer modalities. In this study, a tumor-targeted redox-responsive composite biocatalyst designed and fabricated, which combine tumor starvation therapy low-temperature photothermal oxygen-deprived tumors. The nanosystem was prepared by loading porous hollow Prussian Blue nanoparticles (PHPBNs) with glucose oxidase (GOx) then coating their surface hyaluronic acid (HA) via redox-cleavable linkage, therefore allowing nanocarrier to bind specifically CD44-overexpressing cells while also exerting control over cargo release profile. nanocarriers are enhance hypoxia-suppressed GOx-mediated catalyzing decomposition intratumoral hydroperoxide into oxygen PHPBNs, enhanced depletion two complementary biocatalysts consequently suppress expression heat shock proteins (HSPs) after reduce resistance PHPBN-mediated therapies.

Language: Английский

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Perspective: The Dietary Inflammatory Index (DII)—Lessons Learned, Improvements Made, and Future Directions

Advances in Nutrition, Journal Year: 2018, Volume and Issue: 10(2), P. 185 - 195

Published: Aug. 22, 2018

Language: Английский

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The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier Integrity

Immunity, Journal Year: 2018, Volume and Issue: 49(2), P. 353 - 362.e5

Published: Aug. 1, 2018

The epithelium and immune compartment in the intestine are constantly exposed to a fluctuating external environment. Defective communication between these compartments at this barrier surface underlies susceptibility infections chronic inflammation. Environmental factors play significant, but mechanistically poorly understood, role intestinal homeostasis. We found that regeneration of epithelial cells (IECs) upon injury through infection or chemical insults was profoundly influenced by environmental sensor aryl hydrocarbon receptor (AHR). IEC-specific deletion Ahr resulted failure control C. rodentium due unrestricted stem cell (ISC) proliferation impaired differentiation, culminating malignant transformation. AHR activation dietary ligands restored homeostasis, protected niche, prevented tumorigenesis via transcriptional regulation Rnf43 Znrf3, E3 ubiquitin ligases inhibit Wnt-β-catenin signaling restrict ISC proliferation. Thus, pathway IECs guards niche maintain integrity.

Language: Английский

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Dietary modifications for enhanced cancer therapy

Nature, Journal Year: 2020, Volume and Issue: 579(7800), P. 507 - 517

Published: March 25, 2020

Language: Английский

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Biomimetic nanoparticles for inflammation targeting

Acta Pharmaceutica Sinica B, Journal Year: 2017, Volume and Issue: 8(1), P. 23 - 33

Published: Dec. 24, 2017

There have been many recent exciting developments in biomimetic nanoparticles for biomedical applications. Inflammation, a protective response involving immune cells, blood vessels, and molecular mediators directed against harmful stimuli, is closely associated with human diseases. As result, mimicking cells can help achieve imaging precise drug delivery to these inflammatory sites. This review focused on inflammation-targeting will provide an in-depth look at the design of maximize their benefits disease diagnosis treatment.

Language: Английский

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Inflammation and Pancreatic Cancer: Focus on Metabolism, Cytokines, and Immunity

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(3), P. 676 - 676

Published: Feb. 5, 2019

Systemic and local chronic inflammation might enhance the risk of pancreatic ductal adenocarcinoma (PDAC), PDAC-associated inflammatory infiltrate in tumor microenvironment concurs enhancing growth metastasis. Inflammation is closely correlated with immunity, same immune cell populations contributing to both response. In PDAC microenvironment, unbalanced towards an immunosuppressive phenotype, a prevalence myeloid derived suppressor cells (MDSC), M2 polarized macrophages, Treg, over M1 dendritic cells, effector CD4+ CD8+ T lymphocytes. The dynamic continuously evolving cross-talk between cancer be direct contact-dependent, but it mainly mediated by soluble exosomes-carried cytokines. Among these, necrosis factor alpha (TNFα) plays relevant role risk, growth, cancer-associated cachexia. this review, we describe types, cytokines, mechanisms underlying progression, particular attention on TNFα, also light potential risks or benefits associated anti-TNFα treatments.

Language: Английский

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