Annual Review of Pathology Mechanisms of Disease,
Journal Year:
2018,
Volume and Issue:
13(1), P. 395 - 412
Published: Jan. 24, 2018
Metastasis
is
the
major
cause
of
cancer-related
deaths;
therefore,
prevention
and
treatment
metastasis
are
fundamental
to
improving
clinical
outcomes.
Epithelial
mesenchymal
transition
(EMT),
an
evolutionarily
conserved
developmental
program,
has
been
implicated
in
carcinogenesis
confers
metastatic
properties
upon
cancer
cells
by
enhancing
mobility,
invasion,
resistance
apoptotic
stimuli.
Furthermore,
EMT-derived
tumor
acquire
stem
cell
exhibit
marked
therapeutic
resistance.
Given
these
attributes,
complex
biological
process
EMT
heralded
as
a
key
hallmark
carcinogenesis,
targeting
pathways
constitutes
attractive
strategy
for
treatment.
However,
demonstrating
necessity
vivo
technically
challenging,
recent
efforts
demonstrate
functional
contribution
have
yielded
unexpected
results.
Therefore,
determining
role
remains
area
active
investigation.
Studies
using
improved
lineage
tracing
systems,
dynamic
imaging,
clinically
relevant
models
potential
uncover
direct
link
between
metastasis.
This
review
focuses
primarily
on
advances
emerging
concepts
biology
discusses
future
directions
context
novel
diagnostic
opportunities.
Genes & Development,
Journal Year:
2018,
Volume and Issue:
32(19-20), P. 1267 - 1284
Published: Oct. 1, 2018
The
presence
of
inflammatory
immune
cells
in
human
tumors
raises
a
fundamental
question
oncology:
How
do
cancer
avoid
the
destruction
by
attack?
In
principle,
tumor
development
can
be
controlled
cytotoxic
innate
and
adaptive
cells;
however,
as
develops
from
neoplastic
tissue
to
clinically
detectable
tumors,
evolve
different
mechanisms
that
mimic
peripheral
tolerance
order
tumoricidal
attack.
Here,
we
provide
an
update
recent
accomplishments,
unifying
concepts,
future
challenges
study
tumor-associated
cells,
with
emphasis
on
metastatic
carcinomas.
