The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development

Advanced Materials, Journal Year: 2018, Volume and Issue: 31(1)

Published: Aug. 20, 2018

Collagen is the oldest and most abundant extracellular matrix protein that has found many applications in food, cosmetic, pharmaceutical, biomedical industries. First, an overview of family collagens their respective structures, conformation, biosynthesis provided. The advances shortfalls various collagen preparations (e.g., mammalian/marine extracted collagen, cell-produced collagens, recombinant collagen-like peptides) crosslinking technologies chemical, physical, biological) are then critically discussed. Subsequently, array structural, thermal, mechanical, biochemical, biological assays examined, which developed to analyze characterize collagenous structures. Lastly, a comprehensive review provided on how engineering, chemistry, biology have enabled development bioactive, 3D structures tissue grafts, biomaterials, cell-assembled equivalents) closely imitate native supramolecular assemblies capacity deliver localized sustained manner viable cell populations and/or bioactive/therapeutic molecules. Clearly, long history both evolution biotechnology continue offer challenges exciting opportunities regenerative medicine as nature's biomaterial choice.

Language: Английский

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A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds

Polymers, Journal Year: 2021, Volume and Issue: 13(7), P. 1105 - 1105

Published: March 30, 2021

Tissue engineering (TE) and regenerative medicine integrate information technology from various fields to restore/replace tissues damaged organs for medical treatments. To achieve this, scaffolds act as delivery vectors or cellular systems drugs cells; thereby, material is able colonize host cells sufficiently meet up the requirements of regeneration repair. This process multi-stage requires development components create desired neo-tissue organ. In several current TE strategies, biomaterials are essential components. While polymers established their use biomaterials, careful consideration environment interactions needed required in selecting a polymer given application. Depending on scaffold materials can be natural synthetic origin, degradable nondegradable. this review, an overview possible composite with physicochemical properties including biocompatibility, biodegradability, morphology, mechanical strength, pore size, porosity discussed. The fabrication techniques few commercially available biopolymers also tabulated.

Language: Английский

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Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment

Chemical Reviews, Journal Year: 2017, Volume and Issue: 117(20), P. 12764 - 12850

Published: Oct. 9, 2017

The cell microenvironment has emerged as a key determinant of behavior and function in development, physiology, pathophysiology. extracellular matrix (ECM) within the serves not only structural foundation for cells but also source three-dimensional (3D) biochemical biophysical cues that trigger regulate behaviors. Increasing evidence suggests 3D character is required development many critical responses observed vivo, fueling surge functional biomimetic materials engineering microenvironment. Progress design such improved control behaviors advanced fields tissue regeneration, vitro models, large-scale differentiation, immunotherapy, gene therapy. However, field still its infancy, discoveries about nature cell–microenvironment interactions continue to overturn much early progress field. Key challenges be dissecting roles chemistry, structure, mechanics, electrophysiology microenvironment, understanding harnessing periodicity drift these factors. This review encapsulates where recent advances appear leave ever-shifting state art, it highlights areas which substantial potential uncertainty remain.

Language: Английский

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Corrosion and surface modification on biocompatible metals: A review

Materials Science and Engineering C, Journal Year: 2017, Volume and Issue: 77, P. 1261 - 1274

Published: April 20, 2017

Language: Английский

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Decellularized extracellular matrix scaffolds: Recent trends and emerging strategies in tissue engineering

Bioactive Materials, Journal Year: 2021, Volume and Issue: 10, P. 15 - 31

Published: Sept. 23, 2021

The application of scaffolding materials is believed to hold enormous potential for tissue regeneration. Despite the widespread and rapid advance several tissue-engineered scaffolds such as natural synthetic polymer-based scaffolds, they have limited repair capacity due difficulties in overcoming immunogenicity, simulating in-vivo microenvironment, performing mechanical or biochemical properties similar native organs/tissues. Fortunately, emergence decellularized extracellular matrix (dECM) provides an attractive way overcome these hurdles, which mimic optimal non-immune environment with three-dimensional structures various bioactive components. consequent cell-seeded construct based on dECM especially stem cell-recellularized construct, considered ideal choice regenerating functional Herein, we review recent developments put forward perspectives accordingly, particular focus concept fabrication well their combinations cells (recellularized scaffolds) engineering, including skin, bone, nerve, heart, along lung, liver kidney.

Language: Английский

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Thermo-responsive polymers and their application as smart biomaterials

Journal of Materials Chemistry B, Journal Year: 2017, Volume and Issue: 5(23), P. 4307 - 4321

Published: Jan. 1, 2017

This review summarises smart thermo-responsive polymeric materials with reversible and ‘on–off’ remotely switchable properties for a wide range of biomedical biomaterials applications.

Language: Английский

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3D Bioprinting for Organ Regeneration

Advanced Healthcare Materials, Journal Year: 2016, Volume and Issue: 6(1)

Published: Dec. 20, 2016

Regenerative medicine holds the promise of engineering functional tissues or organs to heal replace abnormal and necrotic tissues/organs, offering hope for filling gap between organ shortage transplantation needs. Three‐dimensional (3D) bioprinting is evolving into an unparalleled biomanufacturing technology due its high‐integration potential patient‐specific designs, precise rapid manufacturing capabilities with high resolution, unprecedented versatility. It enables control over multiple compositions, spatial distributions, architectural accuracy/complexity, therefore achieving effective recapitulation microstructure, architecture, mechanical properties, biological functions target organs. Here we provide overview recent advances in 3D technology, as well design concepts bioinks suitable process. We focus on applications this living organs, focusing more specifically vasculature, neural networks, heart liver. conclude current challenges technical perspective further development bioprinting.

Language: Английский

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Electrospun Fibrous Scaffolds for Tissue Engineering: Viewpoints on Architecture and Fabrication

International Journal of Molecular Sciences, Journal Year: 2018, Volume and Issue: 19(3), P. 745 - 745

Published: March 6, 2018

Electrospinning has been used for the fabrication of extracellular matrix (ECM)-mimicking fibrous scaffolds several decades. Electrospun provide nanoscale/microscale structures with interconnecting pores, resembling natural ECM in tissues, and showing a high potential to facilitate formation artificial functional tissues. In this review, we summarize fundamental principles electrospinning processes generating complex scaffold geometries that are similar structural complexity living Moreover, approaches three-dimensional arranged hierarchical tissue engineering also presented.

Language: Английский

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Bacterial Cellulose-Based Composite Scaffolds for Biomedical Applications: A Review

ACS Sustainable Chemistry & Engineering, Journal Year: 2020, Volume and Issue: 8(20), P. 7536 - 7562

Published: April 30, 2020

Bacterial cellulose (BC), with non-toxicity, high purity, and biocompatibility, has been considered as a versatile candidate for various biomedical applications. Recently, the fabrication of BC-based composite scaffolds compounded other ingredients such nanoparticles polymers received extensive investigation, which enabled development numerous promising products. Additionally, BC-derived nanocrystals (BCNCs) nanofibrils (BCNFs) have proven to be reinforcing agents in variety polymeric In this review, we summarize recent preparation strategies BCNCs- BCNFs-containing their advances applications, including wound healing, tissue engineering, drug delivery, well tumor cell culture cancer treatment. Finally, present challenges future perspectives

Language: Английский

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Decellularized Extracellular Matrix-based Bioinks for Engineering Tissue- and Organ-specific Microenvironments

Chemical Reviews, Journal Year: 2020, Volume and Issue: 120(19), P. 10608 - 10661

Published: July 31, 2020

Biomaterials-based biofabrication methods have gained much attention in recent years. Among them, 3D cell printing is a pioneering technology to facilitate the recapitulation of unique features complex human tissues and organs with high process flexibility versatility. Bioinks, combinations printable hydrogel cells, can be utilized create cell-printed constructs. The bioactive cues bioinks directly trigger cells induce tissue morphogenesis. various hydrogels, tissue- organ-specific decellularized extracellular matrix (dECM) exert synergistic effects supporting at any component by facilitating specific physiological properties. In this review, we aim discuss new paradigm dECM-based able recapitulate inherent microenvironmental niche This review serve as toolbox for biomedical engineers who want understand beneficial characteristics basic set fundamental criteria functional organs.

Language: Английский

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