Anxiety Cells in a Hippocampal-Hypothalamic Circuit

Neuron, Journal Year: 2018, Volume and Issue: 97(3), P. 670 - 683.e6

Published: Jan. 31, 2018

Language: Английский

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Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems

Cell, Journal Year: 2018, Volume and Issue: 175(2), P. 472 - 487.e20

Published: Aug. 23, 2018

Language: Английский

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Neurobiological links between stress and anxiety

Neurobiology of Stress, Journal Year: 2019, Volume and Issue: 11, P. 100191 - 100191

Published: Aug. 13, 2019

Stress and anxiety have intertwined behavioral neural underpinnings. These commonalities are critical for understanding each state, as well their mutual interactions. Grasping the mechanisms underlying this bidirectional relationship will major clinical implications managing a wide range of psychopathologies. After briefly defining key concepts study stress in pre-clinical models, we present circuit, cellular molecular involved either or both anxiety. First, review studies on divergent circuits basolateral amygdala (BLA) emotional valence processing anxiety-like behaviors, how norepinephrine inputs from locus coeruleus (LC) to BLA responsible acute-stress induced We then describe recent revealing new role mitochondrial function within nucleus accumbens (NAc), individual trait rodents, participating link between Next, report findings impact reward encoding through alteration circuit dynamic synchronicity. Finally, work unravelling hypothalamic corticotropin-releasing hormone (CRH) neurons controlling stress-induce behaviors. Altogether, research reviewed here reveals sharing subcortical nodes Understanding overlap these two psychobiological states, might provide alternative strategies manage disorders such post-traumatic disorder (PTSD).

Language: Английский

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Stress and the brain: individual variability and the inverted-U

Nature Neuroscience, Journal Year: 2015, Volume and Issue: 18(10), P. 1344 - 1346

Published: Sept. 25, 2015

Language: Английский

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Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons

Nature Immunology, Journal Year: 2020, Volume and Issue: 21(11), P. 1421 - 1429

Published: Sept. 14, 2020

Language: Английский

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Contributions of the Central Extended Amygdala to Fear and Anxiety

Journal of Neuroscience, Journal Year: 2016, Volume and Issue: 36(31), P. 8050 - 8063

Published: Aug. 3, 2016

It is widely thought that phasic and sustained responses to threat reflect dissociable circuits centered on the central nucleus of amygdala (Ce) bed stria terminalis (BST), two major subdivisions extended amygdala. Early versions this hypothesis remain highly influential have been incorporated into National Institute Mental Health Research Domain Criteria framework. However, new observations encourage a different perspective. Anatomical studies show Ce BST form tightly interconnected unit, where kinds threat-relevant information can be integrated used assemble states fear anxiety. Imaging in humans monkeys exhibit similar functional profiles. Both regions are sensitive range aversive challenges, including uncertain or temporally remote threat; both covary with concurrent signs symptoms anxiety; short-lived heightened activity during exposure diffusely threatening contexts. Mechanistic demonstrate control expression anxiety diffuse threat. These compel reconsideration amygdala9s contributions its role neuropsychiatric disease.

Language: Английский

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Inhibition in the amygdala anxiety circuitry

Experimental & Molecular Medicine, Journal Year: 2018, Volume and Issue: 50(4), P. 1 - 16

Published: April 1, 2018

Inhibitory neurotransmission plays a key role in anxiety disorders, as evidenced by the anxiolytic effect of benzodiazepine class γ-aminobutyric acid (GABA) receptor agonists and recent discovery anxiety-associated variants molecular components inhibitory synapses. Accordingly, substantial interest has focused on understanding how neurons synapses contribute to circuitry underlying adaptive pathological behaviors. A element is amygdala, which integrates information from cortical thalamic sensory inputs generate fear anxiety-related behavioral outputs. Information processing within amygdala heavily dependent control, although specific mechanisms GABAergic regulate behaviors are only beginning be uncovered. Here, we summarize current state knowledge highlight open questions regarding inhibition circuitry. We discuss neuron subtypes that basolateral central well determinants, such GABA receptors synapse organizer proteins, shape synaptic transmission Finally, conclude with an overview future approaches for converting this into successful treatment strategies disorders. Understanding developing more effective therapeutics against anxiety. Anxiety disorders most prevalent group psychiatric diseases, yet they often under-treated due limited efficacy tolerability approaches. Dilja Krueger-Burg colleagues at Max Planck Institute Experimental Medicine Göttingen, Germany, review neuronal circuits brain region emotions. It established alterations excessive excitatory underlie Using latest technologies identify populations implicated regulation should help develop new targeted treatments fewer side-effects.

Language: Английский

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Hunger-Driven Motivational State Competition

Neuron, Journal Year: 2016, Volume and Issue: 92(1), P. 187 - 201

Published: Oct. 1, 2016

Language: Английский

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Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal

Neuropsychopharmacology, Journal Year: 2016, Volume and Issue: 42(1), P. 46 - 61

Published: June 20, 2016

Language: Английский

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Dispositional negativity: An integrative psychological and neurobiological perspective.

Psychological Bulletin, Journal Year: 2016, Volume and Issue: 142(12), P. 1275 - 1314

Published: Oct. 11, 2016

Dispositional negativity-the propensity to experience and express more frequent, intense, or enduring negative affect-is a fundamental dimension of childhood temperament adult personality. Elevated levels dispositional negativity can have profound consequences for health, wealth, happiness, drawing the attention clinicians, researchers, policymakers. Here, we highlight recent advances in our understanding psychological neurobiological processes linking stable individual differences momentary emotional states. Self-report data suggest that 3 key pathways-increased stressor reactivity, tonic increases affect, increased exposure-explain most heightened affect characterizes individuals with disposition. Of these pathways, tonically elevated, indiscriminate appears be central daily life relevant development psychopathology. New behavioral biological provide insights into neural systems underlying pathways motivate hypothesis seemingly "tonic" may actually reflect reactivity stressors are remote, uncertain, diffuse. Research focused on humans, monkeys, rodents suggests this reflects trait-like variation activity connectivity several brain regions, including extended amygdala parts prefrontal cortex. Collectively, observations an integrative psychobiological framework dynamic cascade bind traits states and, ultimately, disorders other kinds adverse outcomes. (PsycINFO Database Record

Language: Английский

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