Fasting and cancer: molecular mechanisms and clinical application

Nature reviews. Cancer, Journal Year: 2018, Volume and Issue: 18(11), P. 707 - 719

Published: Oct. 16, 2018

Language: Английский

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Applications and Limitations of Dendrimers in Biomedicine

Molecules, Journal Year: 2020, Volume and Issue: 25(17), P. 3982 - 3982

Published: Sept. 1, 2020

Biomedicine represents one of the main study areas for dendrimers, which have proven to be valuable both in diagnostics and therapy, due their capacity improving solubility, absorption, bioavailability targeted distribution. Molecular cytotoxicity constitutes a limiting characteristic, especially cationic higher-generation dendrimers. Antineoplastic research dendrimers has been widely developed, several types poly(amidoamine) poly(propylene imine) dendrimer complexes with doxorubicin, paclitaxel, imatinib, sunitinib, cisplatin, melphalan methotrexate shown an improvement comparison drug molecule alone. The anti-inflammatory therapy focused on ibuprofen, indomethacin, piroxicam, ketoprofen diflunisal. In context development antibiotic-resistant bacterial strains, fluoroquinolones, macrolides, beta-lactamines aminoglycosides promising effects. Regarding antiviral studies performed develop conjugates tenofovir, maraviroc, zidovudine, oseltamivir acyclovir, among others. Furthermore, cardiovascular strongly addressed Employed imaging diagnostics, reduce dosage required obtain images, thus efficiency radioisotopes. Dendrimers are macromolecular structures multiple advantages that can suffer modifications depending chemical nature transported. results obtained so far encourage pursuit new studies.

Language: Английский

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Mechanisms of cancer resistance in long-lived mammals

Nature reviews. Cancer, Journal Year: 2018, Volume and Issue: 18(7), P. 433 - 441

Published: April 5, 2018

Language: Английский

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Actigraphy-Measured Sleep Disruption as a Predictor of Survival among Women with Advanced Breast Cancer

SLEEP, Journal Year: 2014, Volume and Issue: 37(5), P. 837 - 842

Published: April 30, 2014

Poor sleep, prevalent among cancer survivors, is associated with disrupted hormonal circadian rhythms and poor quality of life. Using a prospective research design, this study aimed to clarify the relationship between objective measures sleep efficiency disruption survival women advanced breast cancer.We examined duration via wrist-worn actigraphy diaries for 3 days 97 in whom was diagnosed (age = 54.6 ± 9.8 years). Sleep operationalized using as ratio total time plus wake after onset.As hypothesized, better found predict significant reduction overall mortality (hazard [HR], 0.96; 95% confidence interval [CI], 0.94-0.98; P < 0.001) at median 6 y follow-up. This remained (HR, 0.94; CI, 0.91-0.97; even adjusting other known prognostic factors (age, estrogen receptor status, treatment, metastatic spread, cortisol levels, depression). Secondary hypotheses were also supported (after baseline factors) showing that less onset 0.41; 0.25-0.67; 0.001), fewer episodes, 0.93; 0.88-0.98; 0.007); shorter episode 0.29; 0.14-0.58; contributed reductions mortality.These findings show are independent cancer. Further needed determine whether treating cognitive behavioral and/or pharmacologic therapy could improve

Language: Английский

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Chemotherapy-related cachexia is associated with mitochondrial depletion and the activation of ERK1/2 and p38 MAPKs

Oncotarget, Journal Year: 2016, Volume and Issue: 7(28), P. 43442 - 43460

Published: June 2, 2016

Cachexia affects the majority of cancer patients, with currently no effective treatments. is defined by increased fatigue and loss muscle function resulting from fat depletion. Previous studies suggest that chemotherapy may contribute to cachexia, although causes responsible for this association are not clear. The purpose study was investigate mechanism(s) associated chemotherapy-related effects on body composition function. Normal mice were administered regimens used treatment colorectal cancer, such as Folfox (5-FU, leucovorin, oxaliplatin) or Folfiri irinotecan) 5 weeks. animals received exhibited concurrent mass weakness. Consistently previous findings, wasting up-regulation ERK1/2 p38 MAPKs. No changes in ubiquitin-dependent proteolysis expression TGFβ-family members detected. Further, marked decreases mitochondrial content, abnormalities at sarcomeric level increase number glycolytic fibers observed receiving chemotherapy. Finally, ACVR2B/Fc PD98059 prevented Folfiri-associated activation myofiber atrophy C2C12 cultures. Our findings demonstrate promotes MAPK-dependent well depletion alterations units. Therefore, these potentially plays a causative role occurrence Moreover, present observations provide strong rationale testing MEK1 inhibitors combination anticancer drugs novel strategies aimed preventing chemotherapy-associated atrophy.

Language: Английский

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MOFs-based nanoagent enables dual mitochondrial damage in synergistic antitumor therapy via oxidative stress and calcium overload

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Nov. 4, 2021

Abstract Targeting subcellular organelle with multilevel damage has shown great promise for antitumor therapy. Here, we report a core-shell type of nanoagent iron (III) carboxylate metal-organic frameworks (MOFs) as shell while upconversion nanoparticles (UCNPs) core, which enables near-infrared (NIR) light-triggered synergistically reinforced oxidative stress and calcium overload to mitochondria. The folate decoration on MOFs shells efficient cellular uptake nanoagents. Based the ability UCNPs, NIR light mediates Fe 3+ -to-Fe 2+ reduction simultaneously activates photoacid generator (pHP) encapsulated in cavities, release free acidification intracellular microenvironment, respectively. overexpressed H 2 O mitochondria, highly reactive acidic milieu reinforce Fenton reactions producing lethal hydroxyl radicals (•OH) plasma photoacidification inducing influx, leading mitochondria overload. dual-mitochondria-damage-based therapeutic potency been unequivocally confirmed cell- patient-derived tumor xenograft models vivo.

Language: Английский

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Rational Design in Photopharmacology with Molecular Photoswitches

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(30)

Published: April 7, 2023

Photopharmacology is an attractive approach for achieving targeted drug action with the use of light. In photopharmacology, molecular photoswitches are introduced into structure biologically active small molecules to allow optical control their potency. Going beyond trial and error, photopharmacology has progressively applied rational design methodologies devise light-controlled bioactive ligands. this review, we categorize photopharmacological efforts from standpoint medicinal chemistry strategies, focusing on diffusible photochromic ligands modified that operate through E-Z bond isomerization. vast majority cases, photoswitchable designed as analogs existing compounds, a variety approaches. By analyzing in detail comprehensive list instructive examples, describe state art discuss future opportunities photopharmacology.

Language: Английский

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EGCG adjuvant chemotherapy: Current status and future perspectives

European Journal of Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 250, P. 115197 - 115197

Published: Feb. 10, 2023

The resistance of cancer cells to chemotherapeutic drugs greatly reduces the therapeutic effect in patients, and toxic side effects caused by chemotherapy also seriously affect quality life patients. combination epigallocatechin-3-gallate (EGCG), main active ingredient tea, with cisplatin, 5-FU, doxorubicin paclitaxel enhances their sensitizing on tumors combats drug cells. These seem be mediated a variety mechanisms, including combating stem cells, enhancing sensitivity, inducing cell cycle arrest apoptosis, blocking angiogenesis. In addition, EGCG can suppress series adverse chemotherapy, such as gastrointestinal disorders, nephrotoxicity cardiotoxicity, through its anti-inflammatory antioxidant improve However, low bioavailability off-target reactivity some agents limit clinical application. nanomodification not only antitumor activity but prolongs survival time tumor-bearing mice, has advantage toxicity. Therefore, this review aims discuss current status challenges regarding use treatment cancer. general, is promising adjuvant for chemotherapy.

Language: Английский

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Preservation of muscle mass as a strategy to reduce the toxic effects of cancer chemotherapy on body composition

Current Opinion in Supportive and Palliative Care, Journal Year: 2018, Volume and Issue: 12(4), P. 420 - 426

Published: Aug. 17, 2018

Cancer patients undergoing chemotherapy often experience very debilitating side effects, including unintentional weight loss, nausea, and vomiting. Changes in body composition, specifically lean mass (LBM), are known to have important implications for anticancer drug toxicity cancer prognosis. Currently, dosing is based on calculation of surface area, although this approximation does not take into consideration the variability adipose tissue mass.

Language: Английский

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Omega-3 fatty acids in cancer

Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2013, Volume and Issue: 16(2), P. 156 - 161

Published: Jan. 9, 2013

Significant achievements have been obtained in cancer treatment, but the clinical relevance of drug approach daily practice remains questionable due to high costs, limited efficacy, and negligible influence on quality life. A new concept is emerging which based early combination chemotherapy nutrition therapy.Inflammation dictates tumour initiation, progression growth. Omega-3 fatty acids exert anti-inflammatory effects, therefore recent studies investigated their role prevention, cachexia treatment enhancement antitumour therapies. Limited evidence suggests a for omega-3 acid supplementation they shown preserve muscle mass function patients even during active treatment. During chemotherapy, may contribute reduced inflammatory response, whether toxicity can be prevented assessed. Finally, small showed that increase response rate chemotherapy.Combination appears an effective strategy enhance outcome curative palliative trajectory.

Language: Английский

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