Annual Review of Immunology,
Journal Year:
2014,
Volume and Issue:
32(1), P. 403 - 432
Published: March 21, 2014
The
aryl
hydrocarbon
receptor
(AhR),
for
many
years
almost
exclusively
studied
by
the
pharmacology/toxicology
field
its
role
in
mediating
toxicity
of
xenobiotics
such
as
2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD),
has
more
recently
attracted
attention
immunologists.
evolutionary
conservation
this
transcription
factor
and
widespread
expression
immune
system
point
to
important
physiological
functions
that
are
slowly
being
unraveled.
In
particular,
emphasis
is
now
shifting
from
AhR
xenobiotic
pathway
toward
mode
action
response
ligands.
article,
we
review
current
understanding
molecular
interactions
steady
state
presence
infection
inflammation,
with
a
focus
on
barrier
organs
skin,
gut,
lung.
Science,
Journal Year:
2016,
Volume and Issue:
352(6285), P. 539 - 544
Published: April 28, 2016
Microbial
colonization
of
mucosal
tissues
during
infancy
plays
an
instrumental
role
in
the
development
and
education
host
mammalian
immune
system.
These
early-life
events
can
have
long-standing
consequences:
facilitating
tolerance
to
environmental
exposures
or
contributing
disease
later
life,
including
inflammatory
bowel
disease,
allergy,
asthma.
Recent
studies
begun
define
a
critical
period
early
which
disruption
optimal
host-commensal
interactions
lead
persistent
some
cases
irreversible
defects
training
specific
subsets.
Here,
we
discuss
system
this
“window
opportunity,”
when
microbial
has
potentially
impact
on
human
health
disease.
