Cells,
Journal Year:
2024,
Volume and Issue:
13(1), P. 96 - 96
Published: Jan. 2, 2024
Extracellular
biophysical
properties
have
particular
implications
for
a
wide
spectrum
of
cellular
behaviors
and
functions,
including
growth,
motility,
differentiation,
apoptosis,
gene
expression,
cell–matrix
cell–cell
adhesion,
signal
transduction
mechanotransduction.
Cells
not
only
react
to
unambiguously
mechanical
cues
from
the
extracellular
matrix
(ECM),
but
can
occasionally
manipulate
features
in
parallel
with
biological
characteristics,
thus
interfering
downstream
matrix-based
both
physiological
pathological
processes.
Bidirectional
interactions
between
cells
(bio)materials
vitro
alter
cell
phenotype
mechanotransduction,
as
well
ECM
structure,
intentionally
or
unintentionally.
Interactions
mechanics
vivo
are
importance
variety
diseases,
primarily
cancer.
Stiffness
values
normal
cancerous
tissue
range
500
Pa
(soft)
48
kPa
(stiff),
respectively.
Even
shear
flow
increase
0.1–1
dyn/cm2
(normal
tissue)
1–10
(cancerous
tissue).
There
currently
many
new
areas
activity
tumor
research
on
various
length
scales,
which
highlighted
this
review.
Moreover,
complexity
cancer
is
reduced
common
different
tumors
characteristics
identify
main
pathways
interaction.
This
all
contributes
standardization
mechanotransduction
models
approaches,
which,
ultimately,
increases
understanding
complex
Finally,
effects
mechanics–biology
pairing
key
insights
clinical
practice
treatment
and,
consequently,
translation.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(4), P. 6527 - 6540
Published: April 15, 2022
Despite
considerable
advancements
in
cell
membrane-camouflaged
nanocarriers
to
leverage
natural
functions,
artificial
that
can
accurately
mimic
both
the
biological
and
physical
properties
of
cells
are
urgently
needed.
Herein,
inspired
by
important
effect
stiffness
deformability
red
blood
(RBCs)
on
their
life
span
flowing
through
narrow
vessels,
we
report
construction
RBC
RBCs
at
different
stages
study
how
RBC-derived
affects
behaviors.
membrane-coated
elastic
poly(ethylene
glycol)
diacrylate
hydrogel
nanoparticles
(RBC-ENPs)
simulating
dynamic
exhibited
high
immunocompatibility
with
minimum
immunoglobulin
adsorption
surface
protein
corona,
resulting
reduced
opsonization
macrophages
ultralong
circulation.
Furthermore,
RBC-ENPs
deform
like
achieve
excellent
diffusion
tumor
extracellular
matrix,
leading
improved
multicellular
spheroid
penetration
tissue
accumulation.
In
mouse
cancer
models,
doxorubicin-loaded
demonstrated
superior
antitumor
efficacy
first-line
chemotherapeutic
drug
PEGylated
doxorubicin
liposomes.
Our
work
highlights
tuning
membrane-derived
may
offer
an
alternative
approach
for
bionic
design
nanomedicines
future.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(9)
Published: Jan. 19, 2023
The
extracellular
matrix
(ECM)
is
a
highly
dynamic
system
that
constantly
offers
physical,
biological,
and
chemical
signals
to
embraced
cells.
Increasing
evidence
suggests
mechanical
derived
from
the
cellular
microenvironment
are
essential
controllers
of
cell
behaviors.
Conventional
culture
biomaterials,
with
static
properties
such
as
chemistry,
topography,
stiffness,
have
offered
fundamental
understanding
various
vital
biochemical
biophysical
processes,
adhesion,
spreading,
migration,
growth,
differentiation.
At
present,
novel
biomaterials
can
spatiotemporally
impart
cues
manipulate
fate
emerging.
adaptive
traits
new
materials
endow
them
ability
adapt
requirements
enhance
functions.
In
this
review,
an
introductory
overview
key
players
mechanobiology
provided.
A
perspective
on
state-of-the-art
manipulation
techniques
in
designing
ECM-mimicking
taken.
particular,
different
regulating
mechanosensing
functions
compared.
This
review
benefit
development
engineering
biomechanical
systems
expected.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(21)
Published: April 29, 2023
Abstract
Cells
interact
with
their
surrounding
environment
through
a
combination
of
static
and
dynamic
mechanical
signals
that
vary
over
stimulus
types,
intensity,
space,
time.
Compared
to
such
as
stiffness,
porosity,
topography,
the
current
understanding
on
effects
stimulations
cells
remains
limited,
attributing
lack
access
devices,
complexity
experimental
set‐up,
data
interpretation.
Yet,
in
pursuit
emerging
translational
applications
(e.g.,
cell
manufacturing
for
clinical
treatment),
it
is
crucial
understand
how
respond
variety
forces
are
omnipresent
vivo
so
they
can
be
exploited
enhance
therapeutic
outcomes.
With
rising
appreciation
extracellular
matrix
(ECM)
key
regulator
biofunctions,
researchers
have
bioengineered
suite
ECM‐mimicking
hydrogels,
which
fine‐tuned
spatiotemporal
cues
model
complex
profiles.
This
review
first
discusses
stimuli
may
impact
different
cellular
components
various
mechanobiology
pathways
involved.
Then,
hydrogels
designed
incorporate
parameters
influence
behaviors
described.
The
Scopus
database
also
used
analyze
relative
strength
evidence,
ranging
from
strong
weak,
based
number
published
literatures,
associated
citations,
treatment
significance.
Additionally,
impacts
clinically
relevant
types
including
mesenchymal
stem
cells,
fibroblasts,
immune
evaluated.
aim
draw
attention
paucity
studies
well
highlight
potential
using
cocktail
intensities
fates
(similar
concept
biochemical
direct
fate).
It
envisioned
this
progress
report
will
inspire
more
exciting
development
mechanoresponsive
biomedical
applications.
Journal of Cell Science,
Journal Year:
2023,
Volume and Issue:
136(18)
Published: Sept. 15, 2023
ABSTRACT
Shear
stress
is
essential
for
normal
physiology
and
malignancy.
Common
physiological
processes
–
such
as
blood
flow,
particle
flow
in
the
gut,
or
contact
between
migratory
cell
clusters
their
substrate
produce
shear
that
can
have
an
impact
on
behavior
of
different
tissues.
In
addition,
has
roles
biomedical
interest,
wound
healing,
cancer
fibrosis
induced
by
soft
implants.
Thus,
understanding
how
cells
react
adapt
to
important.
this
Review,
we
discuss
vivo
vitro
data
obtained
from
vascular
epithelial
models;
highlight
insights
these
afforded
regarding
general
mechanisms
through
which
sense,
transduce
respond
at
cellular
levels;
outline
changes
experience
response
tissue
organization.
Finally,
role
collective
migration,
only
starting
be
appreciated.
We
review
our
current
effects
context
embryo
development,
fibrosis,
invite
scientific
community
further
investigate
scenarios.
Cells,
Journal Year:
2024,
Volume and Issue:
13(1), P. 96 - 96
Published: Jan. 2, 2024
Extracellular
biophysical
properties
have
particular
implications
for
a
wide
spectrum
of
cellular
behaviors
and
functions,
including
growth,
motility,
differentiation,
apoptosis,
gene
expression,
cell–matrix
cell–cell
adhesion,
signal
transduction
mechanotransduction.
Cells
not
only
react
to
unambiguously
mechanical
cues
from
the
extracellular
matrix
(ECM),
but
can
occasionally
manipulate
features
in
parallel
with
biological
characteristics,
thus
interfering
downstream
matrix-based
both
physiological
pathological
processes.
Bidirectional
interactions
between
cells
(bio)materials
vitro
alter
cell
phenotype
mechanotransduction,
as
well
ECM
structure,
intentionally
or
unintentionally.
Interactions
mechanics
vivo
are
importance
variety
diseases,
primarily
cancer.
Stiffness
values
normal
cancerous
tissue
range
500
Pa
(soft)
48
kPa
(stiff),
respectively.
Even
shear
flow
increase
0.1–1
dyn/cm2
(normal
tissue)
1–10
(cancerous
tissue).
There
currently
many
new
areas
activity
tumor
research
on
various
length
scales,
which
highlighted
this
review.
Moreover,
complexity
cancer
is
reduced
common
different
tumors
characteristics
identify
main
pathways
interaction.
This
all
contributes
standardization
mechanotransduction
models
approaches,
which,
ultimately,
increases
understanding
complex
Finally,
effects
mechanics–biology
pairing
key
insights
clinical
practice
treatment
and,
consequently,
translation.
