Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease

Kidney International, Journal Year: 2013, Volume and Issue: 83(6), P. 1029 - 1041

Published: Jan. 16, 2013

Language: Английский

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Effect of Uremia on Structure and Function of Immune System

Journal of Renal Nutrition, Journal Year: 2011, Volume and Issue: 22(1), P. 149 - 156

Published: Dec. 24, 2011

Language: Английский

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Uremia Alters HDL Composition and Function

Journal of the American Society of Nephrology, Journal Year: 2011, Volume and Issue: 22(9), P. 1631 - 1641

Published: July 30, 2011

Functional impairment of HDL may contribute to the excess cardiovascular mortality experienced by patients with renal disease, but effect advanced disease on composition and function is not well understood. Here, we used mass spectrometry biochemical analyses study alterations in proteome lipid isolated from maintenance hemodialysis. We identified a significant increase amount acute phase protein serum amyloid A1, albumin, lipoprotein-associated phospholipase A2, apoC-III composing uremic HDL. Furthermore, contained reduced phospholipid increased triglyceride lysophospholipid. With regard function, these changes impaired ability promote cholesterol efflux macrophages. In summary, altered seems inhibit its cardioprotective properties. Assessing help identify at risk for disease.

Language: Английский

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The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications

Journal of Molecular Medicine, Journal Year: 2011, Volume and Issue: 90(2), P. 175 - 186

Published: Sept. 30, 2011

Language: Английский

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APOL1 Localization in Normal Kidney and Nondiabetic Kidney Disease

Journal of the American Society of Nephrology, Journal Year: 2011, Volume and Issue: 22(11), P. 2119 - 2128

Published: Oct. 14, 2011

In patients of African ancestry, genetic variants in APOL1, which encodes apolipoprotein L1, associate with the nondiabetic kidney diseases, focal segmental glomerulosclerosis (FSGS), HIV-associated nephropathy (HIVAN), and hypertensive nephropathy. Understanding renal localization APOL1 may provide clues that will ultimately help elucidate mechanisms by promote Here, we used immunohistology to examine normal human sections biopsies demonstrating either FSGS (n = 8) or HIVAN 2). Within glomeruli, only localized podocytes. Compared fewer cells stained for even when expression podocyte markers GLEPP1 synaptopodin appeared normal. proximal tubular epithelia kidneys, FSGS, HIVAN. We detected arteriolar endothelium diseased sections. Unexpectedly, both but not media medium artery arterioles contained a subset α-smooth muscle actin-positive APOL1. Comparing distribution disease suggests previously unrecognized arteriopathy contribute pathogenesis ancestry.

Language: Английский

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High Density Lipoprotein Cholesterol and the Risk of All-Cause Mortality among U.S. Veterans

Clinical Journal of the American Society of Nephrology, Journal Year: 2016, Volume and Issue: 11(10), P. 1784 - 1793

Published: Aug. 11, 2016

Background and objectives The relationship between HDL cholesterol all-cause mortality in patients with kidney disease is not clear. We sought to characterize the of risk death examine association by eGFR levels. Design, setting, participants, & measurements built a cohort 1,764,986 men who were United States veterans at least one October 2003 September 2004 followed them until 2013 or death. Results Patients low had higher burden comorbid illnesses. Over median 9.1 years (interquartile range, 7.7–9.4 years), 26,247 (40.1%), 109,222 (32.3%), 152,625 (29.2%), 113,785 (28.5%), 139,803 (31.8%) participants ≤25, >25 <34, ≥34 ≤42, >42 <50, ≥50 mg/dl died. In adjusted survival models, compared referent group (≤25 mg/dl), intermediate levels (>25 <50 mg/dl) associated lower across all eGFR. was partially abrogated those high (≥50 similar category among eGFR<30 ≥90 ml/min per 1.73 m 2 . Analysis deciles spline analyses suggest that follows U-shaped curve. There significant interaction attenuated salutary ( P for <0.01). Presence coronary artery eGFR≥60 <0.05). Conclusions Our results show categories. modified cardiovascular disease.

Language: Английский

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Serum Amyloid A in Uremic HDL Promotes Inflammation

Journal of the American Society of Nephrology, Journal Year: 2012, Volume and Issue: 23(5), P. 934 - 947

Published: Jan. 27, 2012

Uremia impairs the atheroprotective properties of HDL, but mechanisms underlying why this occurs are unknown. Here, we observed that HDL isolated from healthy individuals inhibited production inflammatory cytokines by peripheral monocytes stimulated with a Toll-like receptor 2 agonist. In contrast, majority patients ESRD did not show anti-inflammatory property; many samples even promoted cytokines. To investigate difference, used shotgun proteomics to identify 49 HDL-associated proteins in uremia-specific pattern. Proteins enriched (ESRD-HDL) included surfactant protein B (SP-B), apolipoprotein C-II, serum amyloid A (SAA), and α-1-microglobulin/bikunin precursor. addition, detected some ESRD-enriched earlier stages CKD. We detect difference oxidation status between uremic patients. Regarding function these proteins, only SAA mimicked ESRD-HDL promoting cytokine production. Furthermore, levels inversely correlated its potency. conclusion, has activities defective as result specific changes molecular composition. These data suggest potential link high inflammation cardiovascular mortality uremia.

Language: Английский

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Estimated glomerular filtration rate and albuminuria are independent predictors of cardiovascular events and death in type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study

Diabetologia, Journal Year: 2010, Volume and Issue: 54(1), P. 32 - 43

Published: July 29, 2010

Language: Английский

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Lipid Disorders and Their Relevance to Outcomes in Chronic Kidney Disease

Blood Purification, Journal Year: 2011, Volume and Issue: 31(1-3), P. 189 - 196

Published: Jan. 1, 2011

Cardiovascular disease is the major cause of death in patients with chronic kidney (CKD). and many other complications CKD are mediated by oxidative stress, inflammation, dyslipidemia. This review provides a concise overview nature mechanisms CKD-induced lipid disorders their adverse consequences. Lipid abnormalities end-stage renal characterized by: (a) reduced serum apoA-1 high-density lipoprotein (HDL) concentrations, impaired HDL maturation defective antioxidant, anti-inflammatory reverse cholesterol transport properties; (b) clearance very low-density chylomicrons muscle adipose tissue remnants liver leading to hypertriglyceridemia, accumulation intermediate-density chylomicron remnants, (c) modification LDL favored structural abnormalities, antioxidant activity. Together these result in: uptake oxidized remnant particles macrophages resident cells artery wall which along HDL-mediated causes foam cell formation atherosclerosis, production inflammatory mediators reactive oxygen species leukocytes response stimulation phospholipids intensification stress dissemination circulating lipids lipoproteins via peroxidation chain reaction, (d) heightened injurious effects inflammation due diminished antithrombotic activities HDL, finally (e) ability deliver fuel contributing weakness cachexia commonly occur patients.

Language: Английский

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HDL abnormalities in nephrotic syndrome and chronic kidney disease

Nature Reviews Nephrology, Journal Year: 2015, Volume and Issue: 12(1), P. 37 - 47

Published: Nov. 16, 2015

Language: Английский

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