The Role of Exosomal MicroRNAs in the Tumor Microenvironment of Breast Cancer DOI Open Access
Qingqing Liu, Fu Peng, Jianping Chen

et al.

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(16), P. 3884 - 3884

Published: Aug. 9, 2019

Breast cancer, ranking first among women's cancers worldwide, develops from the breast tissue. Study of tissue is, therefore great significance to diagnosis and treatment cancer. Exosomes, acting as an effective communicator between cells, are in ascendant recent years. One most important cargoes contained exosomes is microRNAs, belonging non-coding RNA family. When exosomal microRNAs absorbed into intracellular location, will act tumor promoters or suppressors by inhibiting translation process target mRNA, thus affecting behavior other stromal cells microenvironment. At present, growing research focuses on different types donor cell sources, their contribution miRNA profiling, biomarker potential, etc. This review aims state function diverse miRNAs medicated cell-cell communication potency some specific enriched molecular markers clinical trials. We also describe mechanism anti-cancer compounds through exploration artificially engineered techniques that lead miRNA-inhibitors for therapeutic use.

Language: Английский

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases DOI
Rajesha Rupaimoole, Frank J. Slack

Nature Reviews Drug Discovery, Journal Year: 2017, Volume and Issue: 16(3), P. 203 - 222

Published: Feb. 17, 2017

Language: Английский

Citations

4136
Dietary phytochemicals and cancer chemoprevention: a review of the clinical evidence DOI Open Access
Ritesh R. Kotecha, Akiyoshi Takami, J. Luis Espinoza

et al.

Oncotarget, Journal Year: 2016, Volume and Issue: 7(32), P. 52517 - 52529

Published: May 24, 2016

// Ritesh Kotecha 1 , Akiyoshi Takami 2 and J. Luis Espinoza 3 Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States America Internal Division Hematology, Aichi University, School Nagakute, Aichi, Japan Hematology Oncology, Kanazawa University Graduate Science, Kanazawa, Correspondence to: Espinoza, email: Keywords : cancer chemoprevention, phytochemicals, resveratrol, curcumin, antioxidants Received December 30, 2015 Accepted May 12, 2016 Published 25, Abstract Cancer chemoprevention involves the use different natural or biologic agents to inhibit reverse tumor growth. Epidemiological pre-clinical data suggest that various phytochemicals dietary compounds possess chemopreventive properties, in-vitro animal studies support these may modulate signaling pathways involved in cell proliferation apoptosis transformed cells, enhance host immune system sensitize malignant cells cytotoxic agents. Despite promising results from experimental studies, only a limited number have been tested clinical trials shown variable results. In this review, we summarize regarding select including lycopene, folates tea polyphenols with emphasis on evidence supporting efficacy high-risk populations.

Language: Английский

Citations

363
Super-Enhancer-Mediated RNA Processing Revealed by Integrative MicroRNA Network Analysis DOI Creative Commons
Hiroshi Suzuki, Richard A. Young, Phillip A. Sharp

et al.

Cell, Journal Year: 2017, Volume and Issue: 168(6), P. 1000 - 1014.e15

Published: March 1, 2017

Language: Английский

Citations

249
The Roles of MicroRNA in Lung Cancer DOI Open Access
Kuan‐Li Wu,

Ying‐Ming Tsai,

Chi‐Tun Lien

et al.

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(7), P. 1611 - 1611

Published: March 31, 2019

Lung cancer is the most devastating malignancy in world. Beyond genetic research, epigenomic studies—especially investigations of microRNAs—have grown rapidly quantity and quality past decade. This has enriched our understanding about basic biology lit up opportunities for potential therapeutic development. In this review, we summarize involvement microRNAs lung carcinogenesis behavior, by illustrating relationship to each hallmark capability, addition, briefly describe clinical applications diagnosis prognosis. Finally, discuss use cancer.

Language: Английский

Citations

243
Biomarkers in Colorectal Cancer: Current Research and Future Prospects DOI Open Access
Olorunseun O. Ogunwobi, Fahad Mahmood,

Akinfemi Akingboye

et al.

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(15), P. 5311 - 5311

Published: July 27, 2020

Colorectal cancer (CRC) is a leading cause of death worldwide, despite progress made in detection and management through surgery, chemotherapy, radiotherapy, immunotherapy. Novel therapeutic agents have improved survival both the adjuvant advanced disease settings, albeit with an increased risk toxicity cost. However, metastatic continues to poor long-term prognosis significant challenges remain due late stage diagnosis treatment failure. Biomarkers are key tool early detection, prognostication, survival, predicting response. The past three decades seen advances genomics molecular pathology biomarkers, allowing for greater individualization therapy positive impact on outcomes. Clinically useful predictive biomarkers aid clinical decision making, such as presence KRAS gene mutations benefit from epidermal growth factor receptor (EGFR) inhibiting antibodies. few been translated into practice highlighting need further investigation. We review range protein, DNA RNA-based under investigation diagnostic, predictive, prognostic properties CRC. In particular, long non-coding RNAs (lncRNA), investigated cancers including colorectal cancer. Specifically, we evaluate potential role lncRNA plasmacytoma variant translocation 1 (PVT1), oncogene, prognostic, biomarker

Language: Английский

Citations

221
Systems and Synthetic microRNA Biology: From Biogenesis to Disease Pathogenesis DOI Open Access

Hironori Matsuyama,

Hiroshi Suzuki

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 21(1), P. 132 - 132

Published: Dec. 24, 2019

MicroRNAs (miRNAs) are approximately 22-nucleotide-long, small non-coding RNAs that post-transcriptionally regulate gene expression. The biogenesis of miRNAs involves multiple steps, including the transcription primary (pri-miRNAs), nuclear Drosha-mediated processing, cytoplasmic Dicer-mediated and loading onto Argonaute (Ago) proteins. Further, control diverse biological pathological processes via silencing target mRNAs. This review summarizes recent findings regarding quantitative aspects miRNA homeostasis, pri-miRNA Ago-mediated asymmetric strand selection, modifications pathway components, as well roles RNA (epitranscriptomics), epigenetics, factor circuits, super-enhancers in regulation. These advances have facilitated a system-level understanding networks, improvement RNAi performance for both gene-specific targeting genome-wide screening. comprehensive modeling function been applied to design synthetic circuits. In addition, relationships between genes provide molecular basis highly biased cell type-specific expression patterns evolution miRNA–target connections, while highlighting importance alterations super-enhancer-associated variety human diseases.

Language: Английский

Citations

212
Metastasis-associated miR-23a from nasopharyngeal carcinoma-derived exosomes mediates angiogenesis by repressing a novel target gene TSGA10 DOI Creative Commons
Lili Bao, Bo You, Si Shi

et al.

Oncogene, Journal Year: 2018, Volume and Issue: 37(21), P. 2873 - 2889

Published: March 7, 2018

Benefiting from more precise imaging and radiotherapy, patients with locoregionally nasopharyngeal carcinoma (NPC) have a significantly higher survival rate. Nonetheless, distant metastasis is still the predominant mode of failure. Advances in cancer research highlighted that pathological angiogenesis necessary for tumor by offering oxygen, nutrients, or cell metastatic conduits. MicroRNAs (miRNAs), class small noncoding RNAs, are increasingly implicated modulation physiological conditions. Currently, we detected miR-23a was highly enriched NPC tissues at premetastatic stage, its levels were associated microvessel density. Subsequently, proved alteration expression modulated growth, migration, tube formation HUVECs vitro affected blood vessel outgrowth zebrafish model. Considering possibility extracellular horizontally transferred CNE2 cells to HUVECs, analyzed encapsulated exosomes, showing overexpression exosomal promoted both vivo. Moreover, provided evidences regulated directly targeting testis-specific gene antigen (TSGA10). Taken together, our findings revealed metastasis-associated NPC-derived exosomes plays an important role mediating TSGA10.

Language: Английский

Citations

184
Liquid biopsy at the frontier of detection, prognosis and progression monitoring in colorectal cancer DOI Creative Commons
Hui Zhou, Liyong Zhu, Jun Song

et al.

Molecular Cancer, Journal Year: 2022, Volume and Issue: 21(1)

Published: March 25, 2022

Abstract Colorectal cancer (CRC) is one of the most common cancers worldwide and a leading cause carcinogenic death. To date, surgical resection regarded as gold standard by operator for clinical decisions. Because conventional tissue biopsy invasive only small sample can sometimes be obtained, it unable to represent heterogeneity tumor or dynamically monitor progression. Therefore, there an urgent need find new minimally noninvasive diagnostic strategy detect CRC at early stage recurrence. Over past years, concept called “liquid biopsy” has gained much attention. Liquid noninvasive, allowing repeated analysis real-time monitoring recurrence, metastasis therapeutic responses. With advanced development molecular techniques in CRC, circulating cells (CTCs), DNA (ctDNA), exosomes, tumor-educated platelet (TEP) detection have achieved interesting inspiring results prominent liquid markers. In this review, we focused on some applications CTCs, ctDNA, exosomes TEPs discuss promising future solve unmet needs patients.

Language: Английский

Citations

165
MiR-9 promotes tumorigenesis and angiogenesis and is activated by MYC and OCT4 in human glioma DOI Creative Commons
Xu Chen, Fan Yang,

Tianze Zhang

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2019, Volume and Issue: 38(1)

Published: Feb. 22, 2019

Glioma, characterized by its undesirable prognosis and poor survival rate, is a serious threat to human health lives. MicroRNA-9 (miR-9) implicated in the regulation of multiple tumors, while mechanisms underlying aberrant expression functional alterations glioma are still controversial. Expressions miR-9 were measured GEO database, patient specimens cell lines. Gain- loss-of-function assays applied identify effects on cells HUVECs vitro vivo. Potential targets predicted bioinformatics further verified via experiments. Transcriptional MYC OCT4 was determined cells. MiR-9 frequently up-regulated cells, could significantly enhance proliferation, migration invasion In addition, be secreted from exosomes then absorbed vascular endothelial leading an increase angiogenesis. COL18A1, THBS2, PTCH1 PHD3 as direct miR-9, which elucidate miR-9-induced malignant phenotypes able bind promoter region trigger transcription. Our results highlight that pivotal for pathogenesis can treated potential therapeutic target glioma.

Language: Английский

Citations

148
Exosome-derived noncoding RNAs in gastric cancer: functions and clinical applications DOI Creative Commons
Xiaohuan Tang, Ting Guo, Gao X

et al.

Molecular Cancer, Journal Year: 2021, Volume and Issue: 20(1)

Published: July 30, 2021

Exosomes are a subpopulation of the tumour microenvironment (TME) that transmit various biological molecules to promote intercellular communication. derived from nearly all types cells and exist in body fluids. Noncoding RNAs (ncRNAs) among most abundant contents exosomes, some ncRNAs with functions specifically packaged into exosomes. Recent studies have revealed exosome-derived play crucial roles tumorigenesis, progression drug resistance gastric cancer (GC). In addition, regulating expression levels exosomal can or suppress GC progression. Moreover, membrane structures exosomes protect degradation by enzymes other chemical substances, significantly increasing stability ncRNAs. Specific hallmarks within be used for exosome identification, specific determine their origin. Therefore, suitable use as diagnostic prognostic biomarkers therapeutic targets. Regulating biogenesis may represent new way block eradicate GC. this review, we summarized origins characteristics analysed association between development.

Language: Английский

Citations

121