Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma

Nature, Journal Year: 2019, Volume and Issue: 567(7747), P. 257 - 261

Published: Feb. 27, 2019

Language: Английский

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Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis

Proceedings of the National Academy of Sciences, Journal Year: 2020, Volume and Issue: 117(49), P. 31189 - 31197

Published: Nov. 23, 2020

Significance This work demonstrates that oncogenic activation of the PI3K-AKT-mTOR signaling pathway suppresses ferroptosis via sterol regulatory element-binding protein-mediated lipogenesis, and inhibition this potentiates cancer therapeutic effect induction. finding unveils mechanisms for regulation provides a potential approach treating patients bearing tumorigenic mutations in pathway.

Language: Английский

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Lipid metabolism reprogramming and its potential targets in cancer

Cancer Communications, Journal Year: 2018, Volume and Issue: 38(1), P. 1 - 14

Published: May 21, 2018

Abstract Reprogramming of lipid metabolism is a newly recognized hallmark malignancy. Increased uptake, storage and lipogenesis occur in variety cancers contribute to rapid tumor growth. Lipids constitute the basic structure membranes also function as signaling molecules energy sources. Sterol regulatory element‐binding proteins (SREBPs), family membrane‐bound transcription factors endoplasmic reticulum, play central role regulation metabolism. Recent studies have revealed that SREBPs are highly up‐regulated various promote SREBP cleavage‐activating protein key transporter trafficking activation well critical glucose sensor, thus linking de novo synthesis. Targeting altered metabolic pathways has become promising anti‐cancer strategy. This review summarizes recent progress our understanding malignancy, highlights potential molecular targets their inhibitors for cancer treatment.

Language: Английский

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Beneficial Outcomes of Omega-6 and Omega-3 Polyunsaturated Fatty Acids on Human Health: An Update for 2021

Nutrients, Journal Year: 2021, Volume and Issue: 13(7), P. 2421 - 2421

Published: July 15, 2021

Oxidative stress and inflammation have been recognized as important contributors to the risk of chronic non-communicable diseases. Polyunsaturated fatty acids (PUFAs) may regulate antioxidant signaling pathway modulate inflammatory processes. They also influence hepatic lipid metabolism physiological responses other organs, including heart. Longitudinal prospective cohort studies demonstrate that there is an association between moderate intake omega-6 PUFA linoleic acid lower cardiovascular diseases (CVDs), most likely a result blood cholesterol concentration. Current evidence suggests increasing arachidonic (up 1500 mg/day) has no adverse effect on platelet aggregation clotting, immune function markers inflammation, but benefit muscle cognitive performance. Many show higher intakes omega-3 PUFAs, especially eicosapentaenoic (EPA) docosahexaenoic (DHA), are associated with incidence characterized by elevated CVDs. This because multiple molecular cellular actions EPA DHA. Intervention trials using + DHA indicate CVD mortality significant inverse linear dose-response relationship found outcomes. In addition their anti-inflammatory roles, considered homeostasis thrombosis, which together potential use in COVID-19 therapy.

Language: Английский

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Lipid metabolism and cancer

The Journal of Experimental Medicine, Journal Year: 2020, Volume and Issue: 218(1)

Published: Dec. 18, 2020

Dysregulation in lipid metabolism is among the most prominent metabolic alterations cancer. Cancer cells harness to obtain energy, components for biological membranes, and signaling molecules needed proliferation, survival, invasion, metastasis, response tumor microenvironment impact cancer therapy. Here, we summarize discuss current knowledge about advances made understanding regulation of introduce different approaches that have been clinically used disrupt

Language: Английский

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Liver X receptors in lipid signalling and membrane homeostasis

Nature Reviews Endocrinology, Journal Year: 2018, Volume and Issue: 14(8), P. 452 - 463

Published: June 14, 2018

Language: Английский

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Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention

Advanced Drug Delivery Reviews, Journal Year: 2020, Volume and Issue: 159, P. 245 - 293

Published: Jan. 1, 2020

With the advent of effective tools to study lipids, including mass spectrometry-based lipidomics, lipids are emerging as central players in cancer biology. Lipids function essential building blocks for membranes, serve fuel drive energy-demanding processes and play a key role signaling molecules regulators numerous cellular functions. Not unexpectedly, cells, well other cell types tumor microenvironment, exploit various ways acquire extensively rewire their metabolism part plastic context-dependent metabolic reprogramming that is driven by both oncogenic environmental cues. The resulting changes fate composition help cells thrive changing microenvironment supporting functions hallmarks, energetics, promoting feedforward signaling, resisting oxidative stresses, regulating intercellular communication immune responses. Supported close connection between altered lipid pathogenic process, specific profiles unique disease biomarkers, with diagnostic, prognostic predictive potential. Multiple preclinical studies illustrate translational promise exploiting cancer, critically, have shown context dependent actionable vulnerabilities can be rationally targeted, particularly combinatorial approaches. Moreover, themselves used membrane disrupting agents or components nanocarriers therapeutics. number compounds strategies approaching clinical trials, we at doorstep hitherto underappreciated hallmark promising target oncologist's strategy combat cancer.

Language: Английский

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Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer’s disease

Nature Genetics, Journal Year: 2021, Volume and Issue: 53(8), P. 1143 - 1155

Published: July 8, 2021

Language: Английский

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Lipid droplets: platforms with multiple functions in cancer hallmarks

Cell Death and Disease, Journal Year: 2020, Volume and Issue: 11(2)

Published: Feb. 6, 2020

Lipid droplets (also known as lipid bodies) are lipid-rich, cytoplasmic organelles that play important roles in cell signaling, metabolism, membrane trafficking, and the production of inflammatory mediators. droplet biogenesis is a regulated process, accumulation these within leukocytes, epithelial cells, hepatocytes, other nonadipocyte cells frequently observed phenotype several physiologic or pathogenic situations thoroughly described during conditions. Moreover, recent years, studies have an increase intracellular different neoplastic processes, although it not clear whether directly involved establishment types malignancies. This review discusses current evidence related to biogenesis, composition functions hallmarks cancer: inflammation, increased proliferation, escape from death, hypoxia. potential markers disease targets for novel anti-inflammatory antineoplastic therapies will be discussed.

Language: Английский

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Macrophages and lipid metabolism

Cellular Immunology, Journal Year: 2018, Volume and Issue: 330, P. 27 - 42

Published: Feb. 2, 2018

Distinct macrophage populations throughout the body display highly heterogeneous transcriptional and epigenetic programs. Recent research has highlighted that these profiles enable different to perform distinct functions as required in their tissue of residence, addition prototypical such innate immunity. These ‘extra’ tissue-specific have been termed accessory functions. One putative function is lipid metabolism, with macrophages lung liver particular being associated this function. As it now appreciated cell metabolism not only provides energy but also greatly influences phenotype cell, here we review how affects specific roles played by pathogenesis lipid-related diseases. In addition, highlight current questions limiting our understanding role metabolism.

Language: Английский

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