Hepatocellular Carcinoma: How the Gut Microbiota Contributes to Pathogenesis, Diagnosis, and Therapy DOI Creative Commons
Wenyu Luo, Shiqi Guo, Yang Zhou

et al.

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13

Published: April 27, 2022

The gut microbiota is gaining increasing attention, and the concept of “gut-liver axis” gradually being recognized. Leaky resulting from injury and/or inflammation can cause translocation flora to liver. Microbiota-associated metabolites components mediate activation a series signalling pathways, thereby playing an important role in development hepatocellular carcinoma (HCC). For this reason, targeting diagnosis, prevention, treatment HCC holds great promise. In review, we summarize mechanisms by which it mediates development, characteristic alterations during pathogenesis. Furthermore, propose several strategies target for prevention HCC, including antibiotics, probiotics, faecal transplantation, immunotherapy.

Language: Английский

A simple “spraying” fluorescence‐guided surgery by AIE probes for liver tumor resection through configuration‐induced cross‐identification DOI Creative Commons
Didi Chen, Tian Xiao, Liangjie Wang

et al.

Aggregate, Journal Year: 2024, Volume and Issue: 5(4)

Published: April 17, 2024

Abstract Surgical resection is the preferred option for hepatocellular carcinoma (HCC), but surgical navigation technology using indocyanine green still has some drawbacks such as non‐specific imaging, thus it very important to develop new fluorescence imaging technology. All‐ cis hexaphenyl‐1,3‐butadiene derivative (ZZ‐HPB‐NC) with aggregation‐induced emission (AIE) feature been reported be quickly turned‐on fluorescent response in intraoperative frozen‐section slides of HCC. However, probe did not respond normal liver tissue around In order enhance diagnostic rate and elucidate mechanism, all‐ trans configuration EE‐HPB‐NC, was furtherly synthesized. Within two minutes, non‐cancer tissues could fluorescently labeled by EE‐HPB‐NC spraying, showing same effect ZZ‐HPB‐NC The results indicated that configuration‐induced cross‐identification strategy achieved through combination ZZ‐ EE‐HPB‐NC. Then mechanism HPB‐NC localization HCC lesions explored, binding specific proteins cells resulted AIE label cells. On this basis, accuracy further verified on mouse hepatic neoplasm models, indicating clinical application potential real‐time navigation.

Language: Английский

Citations

6
Targeting Akt in Hepatocellular Carcinoma and Its Tumor Microenvironment DOI Open Access
Mariam Mroweh, Gaël S. Roth, Thomas Decaens

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(4), P. 1794 - 1794

Published: Feb. 11, 2021

Hepatocellular carcinoma (HCC) is one of the most common causes cancer-related deaths worldwide, and its incidence rising. HCC develops almost exclusively on background chronic liver inflammation, which can be caused by alcohol consumption, viral hepatitis, or an unhealthy diet. The key role inflammation in process hepatocarcinogenesis, including deregulation innate adaptive immune responses, has been demonstrated. inhibition Akt (also known as Protein Kinase B) directly affects cancer cells, but this therapeutic strategy also exhibits indirect anti-tumor activity mediated modulation tumor microenvironment, demonstrated using inhibitors AZD5363, MK-2206, ARQ 092. Moreover, isoforms converge diverge their designated roles, currently available fail to display isoform specificity. Thus, selective needs better explored context possible combination with immunotherapy. This review presents a compact overview current knowledge concerning effect microenvironment.

Language: Английский

Citations

36
ITGB1 Drives Hepatocellular Carcinoma Progression by Modulating Cell Cycle Process Through PXN/YWHAZ/AKT Pathways DOI Creative Commons

Jinghe Xie,

Tingting Guo,

Zhiyong Zhong

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2021, Volume and Issue: 9

Published: Dec. 17, 2021

Integrin β1 (ITGB1), which acts as an extracellular matrix (ECM) receptor, has gained increasing attention a therapeutic target for the treatment of hepatocellular carcinoma (HCC). However, underpinning mechanism how ITGB1 drives HCC progression remains elusive. In this study, we first found that expression was significantly higher in tissues than normal controls by bioinformatics analysis. Furthermore, analysis revealed paxillin (PXN) and 14-3-3 protein zeta (YWHAZ) are molecules participating ITGB1-regulated tumor cell cycle progression. Indeed, immunohistochemistry (IHC) ITGB1, paxillin, YWHAZ were strongly upregulated paired tissue compared with adjacent tissues. Notably, inhibition small interfering RNA (siRNA) resulted downregulated PXN primary cells, assessed western blot immunostaining. addition, knockdown markedly impaired aggressive behavior cells delayed determined migration assay, drug-resistance analysis, colony formation quantitative real-time polymerase chain reaction (qRT-PCR), well viability measurements. More importantly, proved xenograft ITGB1high tumors grew more rapidly ITGB1low tumors. Altogether, our study showed ITGB1/PXN/YWHAZ/protein kinase B (AKT) axis enhances accelerating process, offers promising approach to halt growth.

Language: Английский

Citations

34
Persistently Rising Alpha-fetoprotein in the Diagnosis of Hepatocellular Carcinoma: A Review DOI Open Access
Alla Turshudzhyan, George Y. Wu

Journal of Clinical and Translational Hepatology, Journal Year: 2021, Volume and Issue: 10(1), P. 159 - 163

Published: Oct. 18, 2021

Hepatocellular carcinoma (HCC), one of the most common malignant tumors worldwide, is known for its grim prognosis, with untreated life expectancy being only a matter months after diagnosis. The difficulty in making diagnosis early main contributing factors to poor prognosis. Alpha-fetoprotein (AFP) had long been used as surveillance tool, but suboptimal specificity and sensitivity has prompted liver societies abandon recommendation universal use, even combination ultrasonography. Most studies have shown no obvious correlation between serum AFP level HCC tumor size, stage, or survival post-diagnosis. However, some concluded that gradual rise persistent elevation were positive predictors development. Other reported fall followed by patients well persistently rising levels without development on follow up. Our calculation both low, at 60% 35.8%, respectively, indicating presence per se did not offer diagnostic benefit. In addition, our calculated mean slopes non-HCC numerically very different, difference was statistically significant. We conclude published data do support role HCC.

Language: Английский

Citations

33
Hepatocellular Carcinoma: How the Gut Microbiota Contributes to Pathogenesis, Diagnosis, and Therapy DOI Creative Commons
Wenyu Luo, Shiqi Guo, Yang Zhou

et al.

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13

Published: April 27, 2022

The gut microbiota is gaining increasing attention, and the concept of “gut-liver axis” gradually being recognized. Leaky resulting from injury and/or inflammation can cause translocation flora to liver. Microbiota-associated metabolites components mediate activation a series signalling pathways, thereby playing an important role in development hepatocellular carcinoma (HCC). For this reason, targeting diagnosis, prevention, treatment HCC holds great promise. In review, we summarize mechanisms by which it mediates development, characteristic alterations during pathogenesis. Furthermore, propose several strategies target for prevention HCC, including antibiotics, probiotics, faecal transplantation, immunotherapy.

Language: Английский

Citations

26