Redox metabolism: ROS as specific molecular regulators of cell signaling and function

Molecular Cell, Journal Year: 2021, Volume and Issue: 81(18), P. 3691 - 3707

Published: Sept. 1, 2021

Language: Английский

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Synthesis, applications, toxicity and toxicity mechanisms of silver nanoparticles: A review

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 253, P. 114636 - 114636

Published: Feb. 15, 2023

Silver nanoparticles (AgNPs) have become one of the most popular objects study for past few decades. The ability to design AgNPs through different synthetic methods according application area and desired features is their advantage in many applications. Green synthesis silver has potential methods. Because strong antibacterial activity, been used a wide range applications, such as food packaging medical products devices. With increasing AgNPs, it becoming necessary better understanding toxicity mechanism toxicity. In review, we first describe AgNPs. field then briefly described. mechanisms are discussed.

Language: Английский

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Mitochondria-associated programmed cell death as a therapeutic target for age-related disease

Experimental & Molecular Medicine, Journal Year: 2023, Volume and Issue: 55(8), P. 1595 - 1619

Published: Aug. 23, 2023

Abstract Mitochondria, ubiquitous double-membrane-bound organelles, regulate energy production, support cellular activities, harbor metabolic pathways, and, paradoxically, mediate cell fate. Evidence has shown mitochondria as points of convergence for diverse death-inducing pathways that trigger the various mechanisms underlying apoptotic and nonapoptotic programmed death. Thus, dysfunctional eventually lead or contribute to age-related diseases, such neurodegenerative, cardiovascular diseases. mitochondrion-associated death-based treatments show great therapeutic potential, providing novel insights in clinical trials. This review discusses mitochondrial quality control networks with activity triggered by stimuli maintain homeostasis via mitohormesis, unfolded protein response, mitophagy. The also presents details on forms mitochondria-associated death, including apoptosis, necroptosis, ferroptosis, pyroptosis, parthanatos, paraptosis, highlights their involvement disease pathogenesis, collectively suggesting directions further research.

Language: Английский

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Interindividual variability in transgene mRNA and protein production following adeno-associated virus gene therapy for hemophilia A

Nature Medicine, Journal Year: 2022, Volume and Issue: 28(4), P. 789 - 797

Published: April 1, 2022

Factor VIII gene transfer with a single intravenous infusion of valoctocogene roxaparvovec (AAV5-hFVIII-SQ) has demonstrated clinical benefits lasting 5 years to date in people severe hemophilia A. Molecular mechanisms underlying sustained AAV5-hFVIII-SQ-derived FVIII expression have not been studied humans. In substudy the phase 1/2 trial ( NCT02576795 ), liver biopsy samples were collected 2.6-4.1 after from five participants. Primary objectives examine effects on histopathology, determine transduction pattern and percentage hepatocytes transduced AAV5-hFVIII-SQ genomes, characterize quantify episomal forms vector DNA transgene (hFVIII-SQ RNA hFVIII-SQ protein). Histopathology revealed no dysplasia, architectural distortion, fibrosis or chronic inflammation, endoplasmic reticulum stress was detected expressing protein. Hepatocytes stained positive for showing trend more cells higher doses. analysis presence full-length, inverted terminal repeat-fused, circular which are associated long-term expression. Interindividual differences noted despite similar successful transduction, possibly influenced by host-mediated post-transduction transcription, protein translation secretion. Overall, these results demonstrate persistent structures following administration begin elucidate potential mediating interindividual variability.

Language: Английский

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Oxidative stress in the eye and its role in the pathophysiology of ocular diseases

Redox Biology, Journal Year: 2023, Volume and Issue: 68, P. 102967 - 102967

Published: Nov. 18, 2023

Oxidative stress occurs through an imbalance between the generation of reactive oxygen species (ROS) and antioxidant defense mechanisms cells. The eye is particularly exposed to oxidative because its permanent exposure light due several structures having high metabolic activities. anterior part highly ultraviolet (UV) radiation possesses a complex system protect retina from UV radiation. posterior exhibits rates consumption leading subsequently production rate ROS. Furthermore, inflammation, aging, genetic factors, environmental pollution, are all elements promoting ROS impairing thereby representing risk factors stress. An abnormal redox status was shown be involved in pathophysiology various ocular diseases segment eye. In this review, we aim summarize provide updated understanding on pathogenesis common affecting surface, lens, retina, optic nerve. Moreover, discuss potential therapeutic approaches aimed at reducing context.

Language: Английский

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Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies

Biogerontology, Journal Year: 2023, Volume and Issue: 24(5), P. 609 - 662

Published: July 30, 2023

Language: Английский

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Unfolding the Interactions between Endoplasmic Reticulum Stress and Oxidative Stress

Antioxidants, Journal Year: 2023, Volume and Issue: 12(5), P. 981 - 981

Published: April 22, 2023

Oxidative stress is caused by an imbalance in cellular redox state due to the accumulation of reactive oxygen species (ROS). While homeostatic levels ROS are important for cell physiology and signaling, excess can induce a variety negative effects ranging from damage biological macromolecules death. Additionally, oxidative disrupt function redox-sensitive organelles including mitochondria endoplasmic reticulum (ER). In case ER, misfolded proteins arise stress, leading onset ER stress. To combat cells initiate highly conserved response called unfolded protein (UPR). UPR within context resolving well characterised, how mediators respond influence less defined. this review, we evaluate interplay between signaling networks. Specifically, assess antioxidant responses.

Language: Английский

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Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases

Translational Neurodegeneration, Journal Year: 2023, Volume and Issue: 12(1)

Published: April 14, 2023

Abstract Redox homeostasis refers to the balance between production of reactive oxygen species (ROS) as well nitrogen (RNS), and their elimination by antioxidants. It is linked all important cellular activities oxidative stress a result imbalance pro-oxidants antioxidant species. Oxidative perturbs many activities, including processes that maintain integrity DNA. Nucleic acids are highly therefore particularly susceptible damage. The DNA damage response detects repairs these lesions. Efficient repair essential for maintaining viability, but they decline considerably during aging. deficiencies in increasingly described age-related neurodegenerative diseases, such Alzheimer’s disease, Parkinson’s amyotrophic lateral sclerosis Huntington’s disease. Furthermore, has long been associated with conditions. Moreover, both redox dysregulation increase significantly aging, which biggest risk factor diseases. However, links dysfunction damage, joint contributions pathophysiology conditions, only just emerging. This review will discuss associations address increasing evidence an major source disorders. Understanding connections may facilitate better understanding disease mechanisms, ultimately lead design therapeutic strategies based on preventing

Language: Английский

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Endoplasmic reticulum stress and the unfolded protein response: emerging regulators in progression of traumatic brain injury

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(2)

Published: Feb. 20, 2024

Abstract Traumatic brain injury (TBI) is a common trauma with high mortality and disability rates worldwide. However, the current management of this disease still unsatisfactory. Therefore, it necessary to investigate pathophysiological mechanisms TBI in depth improve treatment options. In recent decades, abundant evidence has highlighted significance endoplasmic reticulum stress (ERS) advancing central nervous system (CNS) disorders, including TBI. ERS following leads accumulation unfolded proteins, initiating protein response (UPR). Protein kinase RNA-like ER (PERK), inositol-requiring 1 (IRE1), activating transcription factor 6 (ATF6) are three major pathways UPR initiation that determine whether cell survives or dies. This review focuses on dual effects discusses underlying mechanisms. It suggested may crosstalk series molecular cascade responses, such as mitochondrial dysfunction, oxidative stress, neuroinflammation, autophagy, death, thus involved progression secondary after Hence, promising candidate for

Language: Английский

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A multifunctional injectable hydrogel for boosted diabetic wound healing assisted by Quercetin-ZIF system

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 495, P. 153425 - 153425

Published: June 22, 2024

Language: Английский

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