Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1879(1), P. 189051 - 189051
Published: Dec. 13, 2023
Language: Английский
Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)
Published: Sept. 8, 2023
Bladder cancer (BCa) is the fourth most common malignant tumor with a poor prognosis worldwide. Further exploration and research are needed to unmask underlying roles molecular mechanisms of circular RNAs. In current study, our findings showed that circXRN2 suppresses progression driven by histone lactylation activating Hippo pathway in human bladder cancer.RNA immunoprecipitation (RIP) followed circRNA sequencing confirmed as object. Overexpression knockdown TAZ/YAP further verified biological functions T24 TCCSUP cells. RIP, coimmunoprecipitation were used elucidate interaction between LATS1. A Seahorse metabolic analyzer was determine glycolytic rate. Cleavage under targets Tagmentation (CUT&Tag) chromatin (ChIP) employed ensure regulatory H3K18 transcriptional activity LCN2.CircXRN2 aberrantly downregulated tissues cell lines. CircXRN2 inhibits proliferation migration cells both vitro vivo. addition, serves negative regulator glycolysis lactate production. Mechanistically, prevents LATS1 from SPOP-mediated degradation binding SPOP degron then activates signaling exert various functions. The circXRN2-Hippo axis modulates inhibiting LCN2 expression cancer.CircXRN2 cancer. Our results indicated novel therapeutic provided promising strategies for clinical intervention
Language: Английский
Citations
85
Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)
Published: Sept. 18, 2024
Language: Английский
Citations
62
Cancer Letters, Journal Year: 2024, Volume and Issue: 597, P. 217076 - 217076
Published: June 19, 2024
Understanding of the metabolic reprogramming has revolutionized our insights into tumor progression and potential treatment. This review concentrates on aberrant pathways in cancer cells within microenvironment (TME). Cancer differ from normal their processing glucose, amino acids, lipids order to adapt heightened biosynthetic energy needs. These shifts, which crucially alter lactic acid, acid lipid metabolism, affect not only cell proliferation but also TME dynamics. explores various immune TME. From a therapeutic standpoint, targeting these alterations represents novel treatment strategy. discusses approaches regulation metabolism different nutrients influencing enhance response. In summary, this summarizes its as target for innovative strategies, offering fresh perspectives
Language: Английский
Citations
19
Cancers, Journal Year: 2024, Volume and Issue: 16(4), P. 680 - 680
Published: Feb. 6, 2024
In recent years, the emergence of cancer drug resistance has been one crucial tumor hallmarks that are supported by level genetic heterogeneity and complexities at cellular levels. Oxidative stress, immune evasion, metabolic reprogramming, overexpression ABC transporters, stemness among several key contributing molecular response mechanisms. Topo-active drugs, e.g., doxorubicin topotecan, clinically active utilized extensively against a wide variety human tumors often result in development failure to therapy. Thus, there is an urgent need for incremental comprehensive understanding mechanisms specifically context topo-active drugs. This review delves into intricate mechanistic aspects these intracellular extracellular explores use potential combinatorial approaches utilizing various drugs inhibitors pathways involved resistance. We believe this will help guide basic scientists, pre-clinicians, clinicians, policymakers toward holistic interdisciplinary strategies transcend resistance, renewing optimism ongoing battle cancer.
Language: Английский
Citations
16
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: May 3, 2024
Abstract Cancer’s complexity is in part due to the presence of intratumor heterogeneity and dynamic nature cancer cell plasticity, which create substantial obstacles effective management. Variability within a tumor arises from existence diverse populations cells, impacting progression, spread, resistance treatments. At core this variability concept cellular plasticity - intrinsic ability cells alter their molecular identity reaction environmental genetic changes. This adaptability cornerstone cancer’s persistence making it formidable target for Emerging studies have emphasized critical role such fostering diversity, turn influences course disease effectiveness therapeutic strategies. The transformative involves network signal transduction pathways, notably those that drive epithelial-to-mesenchymal transition metabolic remodeling, shaping evolutionary path cells. Despite advancements, our understanding precise machinations signaling networks driving these changes still evolving, underscoring necessity further research. editorial presents series entitled “Signaling Cancer Cell Plasticity Intratumor Heterogeneity” Communication Signaling, dedicated unraveling complex processes proposing new avenues intervention.
Language: Английский
Citations
16
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: Jan. 13, 2025
Abstract KRAS is one of the most mutated genes, driving alternations in metabolic pathways that include enhanced nutrient uptaking, increased glycolysis, elevated glutaminolysis, and heightened synthesis fatty acids nucleotides. However, beyond mechanisms KRAS-modulated cancer metabolisms remain incompletely understood. In this review, we aim to summarize current knowledge on KRAS-related alterations cells explore prevalence significance mutation shaping tumor microenvironment influencing epigenetic modification via various molecular activities. Given rely these changes sustain cell growth survival, targeting processes may represent a promising therapeutic strategy for KRAS-driven cancers.
Language: Английский
Citations
4
American Journal of Translational Research, Journal Year: 2024, Volume and Issue: 16(2), P. 432 - 445
Published: Jan. 1, 2024
Background: Human cell division cycle-associated protein 8 (CDCA8), a critical regulator of mitosis, has been identified as prospective prognostic biomarker in several cancer types, including breast, colon, and lung cancers.This study analyzed the diagnostic/prognostic potential clinical implications CDCA8 across diverse cancers.Methods: Bioinformatics molecular experiments.Results: Analyzing TCGA data via TIMER2 GEPIA2 databases revealed significant up-regulation 23 types compared to normal tissues.Prognostically, elevated expression correlated with poorer overall survival KIRC, LUAD, SKCM, emphasizing its marker.UALCAN analysis demonstrated based on variables, such stage, race, gender, these cancers.Epigenetic exploration indicated reduced promoter methylation levels Kidney Renal Clear Cell Carcinoma (KIRC), Lung Adenocarcinoma (LUAD), Skin Cutaneous Melanoma (SKCM) tissues controls.Promoter mutational analyses showcased hypomethylation low mutation rate for cancers.Correlation positive associations between infiltrating immune cells, particularly CD8+ CD4+ T cells.Protein-protein interaction (PPI) network unveiled key interacting proteins, while gene enrichment highlighted their involvement crucial cellular processes pathways.Additionally, CDCA8associated drugs through DrugBank presented therapeutic options SKCM.In vitro validation using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) confirmed LUAD lines (A549 H1299) control .Conclusion: This provides concise insights into CDCA8's multifaceted role covering patterns, diagnostic relevance, epigenetic regulation, landscape, infiltration, implications.
Language: Английский
Citations
15
Molecular Biotechnology, Journal Year: 2024, Volume and Issue: unknown
Published: April 2, 2024
In the dynamic landscape of targeted therapeutics, drug discovery has pivoted towards understanding underlying disease mechanisms, placing a strong emphasis on molecular perturbations and target identification. This paradigm shift, crucial for discovery, is underpinned by big data, transformative force in current era. Omics characterized its heterogeneity enormity, ushered biological biomedical research into data domain. Acknowledging significance integrating diverse omics strata, known as multi-omics studies, researchers delve intricate interrelationships among various layers. review navigates expansive landscape, showcasing tailored assays each layer through genomes to metabolomes. The sheer volume generated necessitates sophisticated informatics techniques, with machine-learning (ML) algorithms emerging robust tools. These datasets not only refine classification but also enhance diagnostics foster development therapeutic strategies. Through integration high-throughput focuses targeting modeling multiple disease-regulated networks, validating interactions targets, enhancing potential using network pharmacology approaches. Ultimately, this exploration aims illuminate impact era, shaping future research.
Language: Английский
Citations
10
Cancer Communications, Journal Year: 2024, Volume and Issue: 44(11), P. 1316 - 1336
Published: Sept. 21, 2024
Abstract Glycosylation, a key mode of protein modification in living organisms, is critical regulating various biological functions by influencing folding, transportation, and localization. Changes glycosylation patterns are significant feature cancer, associated with range pathological activities cancer‐related processes, serve as biomarkers providing new targets for cancer diagnosis treatment. Glycoproteins like human epidermal growth factor receptor 2 (HER2) breast alpha‐fetoprotein (AFP) liver carcinoembryonic antigen (CEA) colon prostate‐specific (PSA) prostate all tumor approved clinical use. Here, we introduce the diversity structures newly discovered substrate—glycosylated RNA (glycoRNA). This article focuses primarily on metastasis, immune evasion, metabolic reprogramming, aberrant ferroptosis responses, cellular senescence to illustrate role cancer. Additionally, summarize applications diagnostics, treatment, multidrug resistance. We envision promising future glycosylation.
Language: Английский
Citations
10
Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)
Published: May 23, 2024
Abstract Background The Enoyl-CoA hydratase/isomerase family plays a crucial role in the metabolism of tumors, being for maintaining energy balance and biosynthetic needs cancer cells. However, enzymes within this that are pivotal gastric (GC) remain unclear. Methods We employed bioinformatics techniques to identify key GC. expression ECHDC2 its clinical significance were validated through tissue microarray analysis. GC was further assessed using colony formation assays, CCK8 assay, EDU Glucose lactic acid subcutaneous tumor experiments nude mice. mechanism action Western blotting, Co-immunoprecipitation, immunofluorescence experiments. Results Our analysis multiple datasets indicates low is significantly associated with poor prognosis. Overexpression notably inhibits aerobic glycolysis proliferation cells both vivo vitro. Further revealed overexpression suppresses P38 MAPK pathway by inhibiting protein level MCCC2, thereby restraining Ultimately, it discovered promotes ubiquitination subsequent degradation MCCC2 binding NEDD4. Conclusions These findings underscore regulating cells, suggesting as potential therapeutic target
Language: Английский
Citations
9