Bi‐Pt Heterojunction Cascade Reaction Platform for Sono‐Immunotherapy of Tumors via PANoptosis and Ferroptosis

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Abstract Sonodynamic therapy (SDT) represents a promising, noninvasive, and precise treatment modality for tumors, demonstrating significant potential in clinical applications. However, the efficiency of sonosensitizers generating reactive oxygen species (ROS) is often limited by rapid electron‐hole recombination. In this study, BiF 3 @BiOI synthesized via co‐precipitation method, followed in‐situ reduction to decorate it with Pt nanoparticles, resulting @BiOI@Pt‐PVP (BBP) nanocomposite enhancing SDT efficacy. The formation heterojunction enhances charge separation ability. decoration nanoparticles narrows bandgap alters band positions Fermi level BBP, which can effectively mitigate recombination pairs facilitate cascade reaction ROS, thereby improving ROS generation ultrasound excitation. Additionally, bismuth ions BBP generated holes consume glutathione, exacerbating cellular oxidative damage, triggering PANoptosis ferroptosis. Furthermore, demonstrate peroxidase‐like activity, catalyzing endogenous hydrogen peroxide oxygen. These functions are helpful against tumors alleviating hypoxic conditions, reshaping microenvironment, modulating immune cell infiltration capacity, efficacy immunotherapy. dual strategy forming heterojunctions sensitization noble metals sono‐catalytic therapy‐induced activation tumor treatment.

Language: Английский

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Ferroptosis and cuproptosis: Metal-dependent cell death pathways activated in response to classical chemotherapy – Significance for cancer treatment?

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(4), P. 189124 - 189124

Published: May 25, 2024

Apoptosis has traditionally been regarded as the desired cell death pathway activated by chemotherapeutic drugs due to its controlled and non-inflammatory nature. However, recent discoveries of alternative pathways have paved way for immune-stimulatory treatment approaches in cancer. Ferroptosis (dependent on iron) cuproptosis copper) hold promise selective cancer targeting overcoming drug resistance. Copper ionophores iron-bearing nano-drugs show potential clinical therapy single agents adjuvant treatments. Here we review up-to-date evidence involvement metal ion-dependent cytotoxicity classical (alkylating agents, topoisomerase inhibitors, antimetabolites, mitotic spindle inhibitors) their combinations with ferroptosis inducers, indicating prospects, advantages, obstacles use.

Language: Английский

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A bioactive fraction from the leaves of Ceiba pentandra (L.) Gaertn. exhibits antiproliferative activity via cell cycle arrest at the G1/S checkpoint and initiation of apoptosis via poly [ADP-ribose] polymerase 1 (PARP1) cleavage in HeLa cells.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119363 - 119363

Published: Jan. 1, 2025

Language: Английский

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Nanocellulose-chitosan nanocomplex stabilized Pickering emulsions with extremely low internal phase: Stabilization mechanism and application in yogurt

Food Hydrocolloids, Journal Year: 2025, Volume and Issue: unknown, P. 111088 - 111088

Published: Jan. 1, 2025

Language: Английский

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Targeting ferroptosis: the role of non-coding RNAs in hepatocellular carcinoma progression and therapy

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Language: Английский

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Targeting Mitochondrial Dysfunction in Cerebral Ischemia: Advances in Pharmacological Interventions

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 108 - 108

Published: Jan. 18, 2025

The study of mitochondrial dysfunction has become increasingly pivotal in elucidating the pathophysiology various cerebral pathologies, particularly neurodegenerative disorders. Mitochondria are essential for cellular energy metabolism, regulation reactive oxygen species (ROS), calcium homeostasis, and execution apoptotic processes. Disruptions function, driven by factors such as oxidative stress, excitotoxicity, altered ion balance, lead to neuronal death contribute cognitive impairments several brain diseases. Mitochondrial can arise from genetic mutations, ischemic events, hypoxia, other environmental factors. This article highlights critical role progression diseases discusses need targeted therapeutic strategies attenuate damage, restore enhance neuroprotection.

Language: Английский

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Chemical Composition, Antioxidant, Anticancer, and Antibacterial Activities of Roots and Seeds of Ammi visnaga L. Methanol Extract

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(1), P. 121 - 121

Published: Jan. 17, 2024

For centuries, plants and their components have been harnessed for therapeutic purposes, with Ammi visnaga L. (Khella) being no exception to this rich tradition. While existing studies shed light on the cytotoxic antimicrobial properties of seed extracts, there remains a noticeable gap in research about antimicrobial, antioxidant, anticancer potential root extracts. This study seeks address by systematically examining methanol extracts derived from roots A. comparing effects those specifically against breast cancer cells. Notably, absent previous investigations, focuses comparative analysis activities both The extract obtained seeds demonstrated notably higher level total phenolic content (TPC) than its counterpart, measuring 366.57 ± 2.86 270.78 mg GAE/g dry weight extract, respectively. In evaluation antioxidant using DPPH method, IC50 values were determined be 193.46 17.13 μg/mL 227.19 1.48 μg/mL, Turning our attention cytotoxicity cells (MCF-7 MDA-MB-231), displayed similar activities, 92.45 2.14 75.43 2.32 Furthermore, exhibited noteworthy modulation gene expression, upregulating expression caspase Bax mRNA levels while concurrently suppressing anti-apoptotic genes (Bcl-xL Bcl-2), thereby reinforcing as agents. outperforms exhibiting lower minimum inhibitory concentrations (MICs) 3.81 0.24 125 7.63 μg/mL. highlights seeds’ potent antibacterial agents, expanding role disease prevention. Overall, underscores diverse potentials seeds, contributing understanding plant-derived mitigating risks.

Language: Английский

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Necrosis Links Neurodegeneration and Neuroinflammation in Neurodegenerative Disease

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3636 - 3636

Published: March 24, 2024

The mechanisms of neuronal cell death in neurodegenerative disease remain incompletely understood, although recent studies have made significant advances. Apoptosis was previously considered to be the only mechanism diseases. However, findings challenged this dogma, identifying new subtypes necrotic death. present review provides an updated summary necrosis and discusses their potential roles Among numerous subtypes, including necroptosis, paraptosis, ferroptosis, pyroptosis, transcriptional repression-induced atypical (TRIAD) has been identified as a TRIAD is induced by functional deficiency TEAD-YAP self-amplifies via release HMGB1. feasible Alzheimer’s other In addition induction death, HMGB1 released during activates brain inflammatory responses, which link between neurodegeneration neuroinflammation.

Language: Английский

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Advances in Cell‐Rich Inks for Biofabricating Living Architectures

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(27)

Published: April 19, 2024

Abstract Advancing biofabrication toward manufacturing living constructs with well‐defined architectures and increasingly biologically relevant cell densities is highly desired to mimic the biofunctionality of native human tissues. The formulation tissue‐like, cell‐dense inks for remains, however, challenging at various levels bioprinting process. Promising advances have been made this goal, achieving relatively high that surpass those found in conventional platforms, pushing current boundaries closer tissue‐like densities. On focus, herein overarching challenges bioprocessing cell‐rich into clinically grade engineered tissues are discussed, as well most recent ink formulations their processing technologies highlighted. Additionally, an overview foreseen developments field provided critically discussed.

Language: Английский

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Ferroptosis in age-related vascular diseases: Molecular mechanisms and innovative therapeutic strategies

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116356 - 116356

Published: Feb. 29, 2024

Aging, an inevitable aspect of human existence, serves as one the predominant risk factors for vascular diseases. Delving into mystery disease's pathophysiology, profound involvement programmed cell death (PCD) has been extensively demonstrated. PCD is a fundamental biological process that plays crucial role in both normal physiology and pathology, including recently discovered form, ferroptosis. Ferroptosis characterized by its reliance on iron lipid peroxidation, significant disease pathophysiology increasingly acknowledged. This phenomenon not only offers promising therapeutic target but also deepens our understanding complex relationship between ferroptosis age-related Consequently, this article aims to thoroughly review mechanisms enable effective control inhibition It focuses genetic pharmacological interventions, with goal developing innovative strategies combat

Language: Английский

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