Photobiomodulation Photomedicine and Laser Surgery, Journal Year: 2024, Volume and Issue: 42(12), P. 747 - 753
Published: Sept. 24, 2024
Near-infrared (NIR) irradiation has shown potential to stimulate osteogenic differentiation, but the mechanisms are not fully understood. The study is investigate effects of NIR laser on osteoblastic differentiation. Human periodontal ligament stem cells (hPDLSCs) were cultured in medium and exposed 810 nm at 0.5 J/cm
Language: Английский
Bioactive Materials, Journal Year: 2024, Volume and Issue: 40, P. 345 - 365
Published: June 15, 2024
Language: Английский
Citations
17
Materials Today Bio, Journal Year: 2023, Volume and Issue: 23, P. 100834 - 100834
Published: Oct. 20, 2023
Achieving precision treatment in bone tissue engineering (BTE) remains a challenge. Photothermal therapy (PTT), as form of therapy, has been extensively investigated for its safety and efficacy. It demonstrated significant potential the orthopedic diseases such tumors, postoperative infections osteoarthritis. However, high temperatures associated with PTT can lead to certain limitations drawbacks. In recent years, researchers have explored use biomaterials mild photothermal (MPT), which offers promising approach addressing these limitations. This review provides comprehensive overview mechanisms underlying MPT presents compilation agents their utilization strategies repair. Additionally, paper discusses future prospects MPT-assisted regeneration, aiming provide insights recommendations optimizing material design this field.
Language: Английский
Citations
24
Theranostics, Journal Year: 2024, Volume and Issue: 14(10), P. 3859 - 3899
Published: Jan. 1, 2024
Osteoporosis is a systemic skeletal disease caused by an imbalance between bone resorption and formation. Current treatments primarily involve medication hormone therapy. However, these lack directionality are often ineffective for locally severe osteoporosis, with the potential complex adverse reactions. Consequently, treatment strategies using bioactive materials or external interventions have emerged as most promising approaches. This review proposes twelve microenvironmental targets osteoporosis-related pathological changes, including local accumulation of inflammatory factors reactive oxygen species (ROS), mitochondrial dynamics, insulin resistance, disruption cell autophagy, apoptosis, changes in neural secretions, aging cells, increased tissue vascular destruction, decreased regeneration. Additionally, this examines current research status effective biophysical biochemical stimuli based on summarizes advantages optimal parameters different bioengineering to support preclinical clinical osteoporosis Finally, addresses ongoing challenges future prospects.
Language: Английский
Citations
14
Materials Today Bio, Journal Year: 2024, Volume and Issue: 25, P. 100982 - 100982
Published: Feb. 1, 2024
Polyetheretherketone (PEEK) is considered as a promising dental implant material owing to its excellent physicochemical and mechanical properties. However, wide range of applications limited by biologically inert nature. In this study, near-infrared (NIR) light responsive bioactive coating with gold nanoparticles (AuNPs) metronidazole adhered the PEEK surface via dopamine polymerization. Compared pure PEEK, hydrophilicity treated was significantly improved. addition, under NIR light, exhibited photothermal conversion effect, antibiotic can be released from coating. This improved antibacterial properties materials. Moreover, more conducive early adhesion bone mesenchymal stem cells. The results in vitro vivo osteogenic activity studies showed that promoted osseointegration implants, irradiation further ability implants. Through RNA sequencing data mining, potential underlying mechanism promoting formation AuNPs combined interpreted. summary, developed may treatment strategy endows
Language: Английский
Citations
12
Progress in Biophysics and Molecular Biology, Journal Year: 2024, Volume and Issue: 188, P. 55 - 67
Published: March 16, 2024
Language: Английский
Citations
9
ACS Applied Nano Materials, Journal Year: 2023, Volume and Issue: 6(16), P. 15255 - 15265
Published: Aug. 9, 2023
Luminescence nanothermometers based on LaOF:Yb3+, Er3+ upconversion nanoparticles (UCNPs) were investigated in this study. The fluorescence intensity ratio (FIR) of the UCNPs was recorded visible (red) and near-infrared (NIR) regions at different temperatures. impact laser heating prevented by identifying optimal operating conditions that could be used to record FIRs without compromising integrity UCNPs. behavior against exposure time power analyzed recognize critical point power, below which negligible. This approach can perceived as a benchmark for testing luminescent materials using nanothermometry.
Language: Английский
Citations
20
Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11
Published: Jan. 1, 2024
Abstract The intricate nature of oral-maxillofacial structure and function, coupled with the dynamic oral bacterial environment, presents formidable obstacles in addressing repair regeneration bone defects. Numerous characteristics should be noticed repair, such as irregular morphology defects, homeostasis between hosts microorganisms cavity complex periodontal structures that facilitate epithelial ingrowth. Therefore, necessitates restoration materials adhere to stringent specific demands. This review starts exploring these particular requirements by introducing bones then summarizes classifications current respect composition structure. Additionally, we discuss modifications including improving mechanical properties, optimizing surface topography pore adding bioactive components elements, compounds, cells their derivatives. Ultimately, organize a range potential optimization strategies future perspectives for enhancing materials, physical environment manipulation, microbial modulation, osteo-immune regulation, smart stimuli-responsive multifaceted approach poly-pathic treatment, hope providing some insights researchers this field. In summary, analyzes demands especially alveolar bone, concludes corresponding biomaterials aims inspire research pursuit more effective treatment outcomes.
Language: Английский
Citations
6
Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 239, P. 113937 - 113937
Published: May 3, 2024
Language: Английский
Citations
5
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2023, Volume and Issue: 16(1)
Published: Aug. 26, 2023
In the last decades, near-infrared (NIR) light has attracted considerable attention due to its unique properties and numerous potential applications in bioimaging disease treatment. Bone tissue engineering for bone regeneration with help of biomaterials is currently an effective means treating defects. As a controlled source deeper penetration, NIR can provide real-time feedback key information on vivo utilizing fluorescence imaging be used This review provides comprehensive overview light-facilitated engineering, from introduction probes as well light-responsive materials, visualization treatment bone-related diseases. Furthermore, existing challenges future development directions light-based are also discussed. article categorized under: Diagnostic Tools > Vivo Nanodiagnostics Imaging Implantable Materials Surgical Technologies Nanotechnology Tissue Repair Replacement.
Language: Английский
Citations
12
Materials Today Bio, Journal Year: 2023, Volume and Issue: 23, P. 100882 - 100882
Published: Dec. 1, 2023
The clinical treatments of bone defects remain a challenge. Hydrogels containing marrow mesenchymal stem cells (BMSCs) are extensively used to regeneration because excellent biocompatibility and hydrophilicity. However, the insufficient osteo-induction capacity BMSC-loaded hydrogels limits their applications. In this study, bio-active glass (BG) BMSCs were combined with gelatin methacryloyl (GelMA) fabricate composite via photo-crosslinking, regulation was investigated. vitro experiments showed that BG/BMSCs@GelMA hydrogel had cytocompatibility promoted osteogenic differentiation in BMSCs. Furthermore, injected into critical-sized calvarial defects, results further confirmed its angiogenetic capacity. addition, polarization macrophages towards M2 phenotype. summary, novel demonstrated remarkable potential for application due immunomodulatory, as well
Language: Английский
Citations
11