Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons

Nature Neuroscience, Journal Year: 2020, Volume and Issue: 23(9), P. 1125 - 1137

Published: July 27, 2020

Language: Английский

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Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

Nature Neuroscience, Journal Year: 2021, Volume and Issue: 24(4), P. 529 - 541

Published: Feb. 15, 2021

Language: Английский

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The advent of thermoplasmonic membrane distillation

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(14), P. 6087 - 6125

Published: Jan. 1, 2022

The recent discoveries related to the efficient light-to-heat conversion in nanomaterials have enabled implementation of sunlight-driven Membrane Distillation for a desalination at water-energy nexus.

Language: Английский

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Advances in human oxytocin measurement: challenges and proposed solutions

Molecular Psychiatry, Journal Year: 2022, Volume and Issue: 28(1), P. 127 - 140

Published: Aug. 23, 2022

Oxytocin, a neuropeptide known for its role in reproduction and socioemotional processes, may hold promise as therapeutic agent treating social impairments patient populations. However, research has yet to uncover precisely how manipulate this system clinical benefit. Moreover, inconsistent use of standardized validated oxytocin measurement methodologies-including the design study hormone secretion biochemical assays-present unresolved challenges. Human studies measuring peripheral (i.e., plasma, saliva, or urine) central cerebrospinal fluid) concentrations have involved very diverse methods, including different assay techniques, further compounding problem. In present review, we describe scientific value human endogenous concentrations, common issues analysis that researchers face when doing so, our recommendations improving using valid reliable methodologies.

Language: Английский

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Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities

Endocrinology, Journal Year: 2022, Volume and Issue: 163(9)

Published: July 21, 2022

Oxytocin and vasopressin are peptide hormones secreted from the pituitary that well known for their peripheral endocrine effects on childbirth/nursing blood pressure/urine concentration, respectively. However, both peptides also released in brain, where they modulate several aspects of social behaviors. promotes maternal nurturing bonding, enhances reward, increases salience stimuli. Vasopressin modulates communication, investigation, territorial behavior, aggression, predominantly males. Both facilitate memory pair bonding behaviors monogamous species. Here we review latest research delineating neural circuitry brain oxytocin systems summarize recent investigations into circuit-based mechanisms modulating We highlight using modern molecular genetic technologies to map, monitor activity of, or manipulate neuropeptide circuits. Species diversity discussed. conclude with a discussion translational implications improving functioning disorders impairments, such as autism spectrum disorder.

Language: Английский

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A paradigm shift in translational psychiatry through rodent neuroethology

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(3), P. 993 - 1003

Published: Jan. 12, 2023

Abstract Mental disorders are a significant cause of disability worldwide. They profoundly affect individuals’ well-being and impose substantial financial burden on societies governments. However, despite decades extensive research, the effectiveness current therapeutics for mental is often not satisfactory or well tolerated by patient. Moreover, most novel therapeutic candidates fail in clinical testing during expensive phases (II III), which results withdrawal pharma companies from investing field. It also brings into question using animal models preclinical studies to discover new agents predict their potential treating illnesses humans. Here, we focus rodents as propose that they essential investigations candidate agents’ mechanisms action safety efficiency. Nevertheless, argue there need paradigm shift methodologies used measure behavior laboratory settings. Specifically, behavioral readouts obtained short, highly controlled tests impoverished environments social contexts proxies complex human might be limited face validity. Conversely, monitored more naturalistic over long periods display ethologically relevant behaviors reflect evolutionarily conserved endophenotypes translational value. We present how semi-natural setups groups mice individually tagged, video recorded continuously can attainable affordable. open-source machine-learning techniques pose estimation enable continuous automatic tracking individual body parts periods. The trajectories each further subjected supervised machine learning algorithms detection specific (e.g., chasing, biting, fleeing) unsupervised motifs stereotypical movements harder name label manually). Compared animals wild, compatible with neural genetic manipulation techniques. As such, study neurobiological underlying behavior. Hence, suggest such possesses best out classical ethology reductive behaviorist approach may provide breakthrough discovering efficient therapies illnesses.

Language: Английский

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Whole-Brain Wiring Diagram of Oxytocin System in Adult Mice

Journal of Neuroscience, Journal Year: 2022, Volume and Issue: 42(25), P. 5021 - 5033

Published: May 23, 2022

Oxytocin (Oxt) neurons regulate diverse physiological responses via direct connections with different neural circuits. However, the lack of comprehensive input-output wiring diagrams Oxt and their quantitative relationship receptor (Oxtr) expression presents challenges to understanding circuit-specific functions. Here, we establish a whole-brain distribution anatomic connectivity map neurons, Oxtr using high-resolution 3D mapping methods in adult male female mice. We use flatmap describe neuronal four hypothalamic domains including under-characterized tuberal nucleus (TU). paraventricular hypothalamus (PVH) broadly project nine functional circuits that control cognition, brain state, somatic visceral response. In contrast, supraoptic (SO) accessory (AN) nuclei have limited central projection small subset Surprisingly, comparison between output showed no significant correlation across whole brain, suggesting abundant indirect signaling Oxtr-expressing areas. Unlike output, both PVH SO receive similar monosynaptic inputs from mainly thalamic, hypothalamic, cerebral Our results suggest PVH-Oxt serve as modulator integrate external internal information largely reciprocal connection while SO-Oxt act unidirectional hormonal output. summary, our diagram provides insights about distinct behavioral functions brain. SIGNIFICANCE STATEMENT prosocial behavior pain sensation Thus, detailed can provide insight on roles regulating distribution, input long-range entire mouse found controlling Furthermore, identified quantitatively unmatched Oxt-Oxtr relationship, broad signaling. Together, advances neurons.

Language: Английский

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Neurocognitive effects of stress: a metaparadigm perspective

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(7), P. 2750 - 2763

Published: Feb. 9, 2023

Abstract Stressful experiences, both physical and psychological, that are overwhelming (i.e., inescapable unpredictable), can measurably affect subsequent neuronal properties cognitive functioning of the hippocampus. At cellular level, stress has been shown to alter hippocampal synaptic plasticity, spike local field potential activity, dendritic morphology, neurogenesis, neurodegeneration. behavioral found impair learning memory for declarative (or explicit) tasks based on cognition, such as verbal recall in humans spatial rodents, while facilitating those emotion, differential fear conditioning contextual rodents. These vertically related alterations hippocampus, procedurally observed after subjects have undergone stress, generally believed be mediated by recurrently elevated circulating hypothalamic-pituitary-adrenal (HPA) axis effector hormones, glucocorticoids, directly acting neurons densely populated with corticosteroid receptors. The main purposes this review (i) provide a synopsis neurocognitive effects historical context led contemporary HPA dogma basic translational research, (ii) critically reappraise necessity sufficiency glucocorticoid hypothesis (iii) suggest an alternative metaparadigm approach monitor manipulate progression at neural coding level. Real-time analyses reveal activity markers hippocampus used extrapolate across range paradigms resolve scaling dichotomous issues) understand individual differences, thereby providing novel neurophysiological scaffold advancing future research.

Language: Английский

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The neurobiological effects of childhood maltreatment on brain structure, function, and attachment

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: March 11, 2024

Abstract Childhood maltreatment is a risk factor for psychopathologies, and influences brain development at specific periods, particularly during early childhood adolescence. This narrative review addresses phenotypic alterations in sensory systems associated with types of exposure, periods vulnerability to the neurobiological effects maltreatment, relationships between structure, function, connectivity, network architecture; psychopathology; resilience. It also maternal communication attachment disturbances, uses laboratory-based measures infancy case–control studies elucidate reactive disorders children histories. Moreover, we on acute oxytocin disorder methylation regulatory genes. Epigenetic changes may play critical role initiating or producing atypical structural functional maltreatment. However, these could be reversed through psychological pharmacological interventions, by anticipating preventing emergence subsequent psychopathological risks.

Language: Английский

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Reviving-like prosocial behavior in response to unconscious or dead conspecifics in rodents

Science, Journal Year: 2025, Volume and Issue: 387(6736)

Published: Feb. 20, 2025

Whereas humans exhibit emergency responses to assist unconscious individuals, how nonhuman animals react unresponsive conspecifics is less well understood. We report that mice stereotypic behaviors toward or dead social partners, which escalate from sniffing and grooming more forceful actions such as mouth tongue biting pulling. The latter intense actions, prominent in familiar pairs, begin after prolonged immobility unresponsiveness cease when the partner regains activity. Their consequences, including improved airway opening clearance accelerated recovery unconsciousness, suggest rescue-like efforts. Oxytocin neurons hypothalamic paraventricular nucleus respond differentially presence of versus active their activation, along with oxytocin signaling, required for reviving-like actions. This tendency members may enhance group cohesion survival species.

Language: Английский

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