Recent advances in the epithelial barrier theory

International Immunology, Journal Year: 2024, Volume and Issue: 36(5), P. 211 - 222

Published: Jan. 16, 2024

Abstract The epithelial barrier theory links the recent rise in chronic non-communicable diseases, notably autoimmune and allergic disorders, to environmental agents disrupting barrier. Global pollution toxic agent exposure have worsened over six decades because of uncontrolled growth, modernization, industrialization, affecting human health. Introducing new chemicals without any reasonable control their health effects through these years has led documented adverse effects, especially on skin mucosal barriers. These substances, such as particulate matter, detergents, surfactants, food emulsifiers, micro- nano-plastics, diesel exhaust, cigarette smoke, ozone, been shown compromise integrity. This disruption is linked opening tight-junction barriers, inflammation, cell death, oxidative stress, metabolic regulation. Consideration must be given interplay underlying inflammatory medications, affected tissues. review article discusses detrimental effect barrier-damaging compounds involves cellular molecular mechanisms.

Language: Английский

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Mitochondrial function and gastrointestinal diseases

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: 21(8), P. 537 - 555

Published: May 13, 2024

Language: Английский

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Type 2 immunity in allergic diseases

Cellular and Molecular Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Language: Английский

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Metagenome-informed metaproteomics of the human gut microbiome, host, and dietary exposome uncovers signatures of health and inflammatory bowel disease

Cell, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Gut dysbiosis: Ecological causes and causative effects on human disease

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(50)

Published: Dec. 4, 2023

The gut microbiota plays a role in many human diseases, but high-throughput sequence analysis does not provide straightforward path for defining healthy microbial communities. Therefore, understanding mechanisms that drive compositional changes during disease (gut dysbiosis) continues to be central goal microbiome research. Insights from the pathogenesis field show an ecological cause dysbiosis is increased availability of host-derived respiratory electron acceptors, which are dominant drivers community composition. Similar host environment also several chronic illnesses, and better underlying informs approaches causatively link exacerbation symptoms. emerging picture suggests homeostasis maintained by functions control resources governing growth. Defining as weakening these directs attention identifies potential targets therapeutic intervention.

Language: Английский

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Butyrate’s (a short-chain fatty acid) microbial synthesis, absorption, and preventive roles against colorectal and lung cancer

Archives of Microbiology, Journal Year: 2024, Volume and Issue: 206(4)

Published: March 4, 2024

Language: Английский

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Co-exposure of polystyrene nanoplastics and copper induces development toxicity and intestinal mitochondrial dysfunction in vivo and in vitro

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 930, P. 172681 - 172681

Published: April 24, 2024

Language: Английский

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Mitochondrial damage-associated molecular patterns: New perspectives for mitochondria and inflammatory bowel diseases

Mucosal Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Mitochondria are key regulators of inflammatory responses and mitochondrial dysfunction is closely linked to various diseases. Increasing genetic experimental evidence suggests that mitochondria play a critical role in bowel disease (IBD). In the complex environment intestinal tract, epithelial cells (IECs) their possess unique phenotypic features, shaping each other regulating homeostasis inflammation through diverse mechanisms. Here, we focus on IBD induced by damage-associated molecular patterns (mtDAMPs), which comprise components metabolic products. The pathogenic mechanisms mtDAMP signaling pathways mediated two major mtDAMPs, DNA (mtDNA) reactive oxygen species (mtROS), discussed.

Language: Английский

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Age-related alterations in gut homeostasis are microbiota dependent

npj Biofilms and Microbiomes, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 25, 2025

Accumulating data suggest that remodeling aged gut microbiota improves aging-related imbalance in intestinal homeostasis. However, evidence favor of the beneficial effect on stress and immune responses during aging is scarce. The current study revealed old mice presented impaired barrier integrity. Transcriptome sequencing coupled with bioinformatics analysis altered gene expression profiles colon mesenteric lymph nodes, which are involved mainly responses, respectively. Notably, was closely related to differentially expressed genes. Microbiota depletion ameliorated integrity partially reversed inflammatory factors upregulated mice. Furthermore, fecal transplantation from young resulted a significant improvement These findings highlight potential microbiota-targeted interventions physiological processes call for further investigation.

Language: Английский

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Gastro-Intestinal Microbiota in Equines and Its Role in Health and Disease: The Black Box Opens

Microorganisms, Journal Year: 2022, Volume and Issue: 10(12), P. 2517 - 2517

Published: Dec. 19, 2022

Horses are large non-ruminant herbivores and rely on microbial fermentation for energy, with more than half of their maintenance energy requirement coming from occurring in enlarged caecum colon. To achieve that, the gastro-intestinal tract (GIT) horses harbors a broad range various microorganisms, differing each GIT segment, which essential efficient utilization feed, especially to use nutrients that not or little degraded by endogenous enzymes. In addition, like other animal species, microbiota is permanent interplay host's cells involved lot functions among inflammation, immune homeostasis, metabolism. As animals humans, horse gut microbiome sensitive diet, consumption starch, fiber, fat. Age, breeds, stress during competitions, transportation, exercise may also impact microbiome. Because its size complexity, equine prone perturbations caused external internal stressors result digestive diseases gastric ulcer, diarrhea, colic, colitis, thought be linked systemic laminitis, metabolic syndrome obesity. Thus, this review we aim at understanding common core -in terms structure function- segment GIT, as well identifying potential biomarkers health disease crucial anticipate putative perturbations, optimize global practices develop adapted nutritional strategies personalized nutrition.

Language: Английский

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