Hazardous drinking and alcohol use disorders

Nature Reviews Disease Primers, Journal Year: 2022, Volume and Issue: 8(1)

Published: Dec. 22, 2022

Language: Английский

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Recent Perspectives on Sex Differences in Compulsion-Like and Binge Alcohol Drinking

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(7), P. 3788 - 3788

Published: April 6, 2021

Alcohol use disorder remains a substantial social, health, and economic problem drinking levels in women have been increasing recent years. Understanding whether how the underlying mechanisms that drive vary by sex is critical could provide novel, more targeted therapeutic treatments. Here, we examine results from our laboratories others which believe useful insights into similarities differences alcohol patterns across sexes. Findings for binge intake aversion-resistant, compulsion-like are considered, since both likely significant contributors to problems humans. We also describe studies regarding may underlie maladaptive drinking, with some focus on importance of nucleus accumbens (NAcb) core shell regions, several receptor types (dopamine, orexin, AMPA-type glutamate), possible contributions hormones. Finally, discuss stressors such as early life stress anxiety-like states interact contribute drinking. Together, these findings underscore relevance studying female male co-morbid conditions gain true clinically understanding addiction neuropsychiatric treatment.

Language: Английский

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Habit, choice, and addiction

Neuropsychopharmacology, Journal Year: 2020, Volume and Issue: 46(4), P. 689 - 698

Published: Nov. 9, 2020

Language: Английский

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Context, attention, and the switch between habit and goal-direction in behavior

Learning & Behavior, Journal Year: 2021, Volume and Issue: 49(4), P. 349 - 362

Published: Oct. 28, 2021

Abstract This article reviews recent findings from the author’s laboratory that may provide new insights into how habits are made and broken. Habits extensively practiced behaviors automatically evoked by antecedent cues performed without their goal (or reinforcer) “in mind.” Goal-directed actions, in contrast, instrumental because is remembered valued. New results suggest actions transition to habit after extended practice when conditions encourage reduced attention behavior. Consistent with theories of learning, a behavior command less (and become habitual) as its reinforcer becomes well-predicted environment; learning prevented if presentation uncertain. Other not permanent, goal-direction can be restored several environmental manipulations, including exposure unexpected reinforcers or context change. more context-dependent than goal-directed are. Habit causes retroactive interference way reminiscent extinction: It inhibits, but does erase, way. The have implications for understanding habitual control well disordered like addictions.

Language: Английский

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Is addiction a brain disease? A plea for agnosticism and heterogeneity

Psychopharmacology, Journal Year: 2021, Volume and Issue: 239(4), P. 993 - 1007

Published: Nov. 26, 2021

Language: Английский

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The etiologic, theory-based, ontogenetic hierarchical framework of alcohol use disorder: A translational systematic review of reviews.

Psychological Bulletin, Journal Year: 2021, Volume and Issue: 147(10), P. 1075 - 1123

Published: Oct. 1, 2021

Modern nosologies (e.g., ICD-11, DSM-5) for alcohol use disorder (AUD) and dependence prioritize reliability clinical presentation over etiology, resulting in a diagnosis that is not always strongly grounded basic theory research. Within these nosologies, DSM-5 AUD treated as discrete, largely categorical, but graded, phenomenon, which results additional challenges significant phenotypic heterogeneity). Efforts to increase the compatibility between modern conceptualizations of dependence, describe it dimensional partially overlapping with other psychopathology substance disorders) will inspire stronger scientific framework strengthen AUD's validity. We conducted systematic review 144 reviews integrate addiction constructs theories into comprehensive aim identifying fundamental mechanisms implicated AUD. The product this effort was Etiologic, Theory-Based, Ontogenetic Hierarchical Framework (ETOH Framework) mechanisms, outlines superdomains cognitive control, reward, well negative valence emotionality, each subsume narrower, hierarchically-organized components. also outline opponent processes self-awareness key moderators mechanisms. In contrast frameworks, we recommend an increased conceptual role compulsion ETOH serves critical step towards heterogeneous. It has potential improve assessment aid development evidence-based diagnostic measures focus on AUD, consequently facilitating treatment matching.

Language: Английский

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Dopamine Circuit Mechanisms of Addiction-Like Behaviors

Frontiers in Neural Circuits, Journal Year: 2021, Volume and Issue: 15

Published: Nov. 9, 2021

Addiction is a complex disease that impacts millions of people around the world. Clinically, addiction formalized as substance use disorder (SUD), with three primary symptom categories: exaggerated use, social or lifestyle impairment, and risky use. Considerable efforts have been made to model features these criteria in non-human animal research subjects, for insight into underlying neurobiological mechanisms. Here we review evidence from rodent models SUD-inspired criteria, focusing on role striatal dopamine system. We identify distinct mesostriatal nigrostriatal circuit functions behavioral outcomes are relevant addictions SUDs. This work suggests essential not only positive SUDs, such elevated intake craving, but also impairments decision making underlie compulsive behavior, reduced sociality, risk taking. Understanding functional heterogeneity system related networks can offer this symptomatology may lead more targeted treatments.

Language: Английский

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Evaluating the Brain Disease Model of Addiction

Routledge eBooks, Journal Year: 2022, Volume and Issue: unknown

Published: Jan. 4, 2022

Language: Английский

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Pathways to the persistence of drug use despite its adverse consequences

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(6), P. 2228 - 2237

Published: March 30, 2023

Abstract The persistence of drug taking despite its adverse consequences plays a central role in the presentation, diagnosis, and impacts addiction. Eventual recognition appraisal these is to decisions reduce or cease use. However, most appropriate ways conceptualizing face remain unclear. Here we review evidence that there are at least three pathways persistent use negative A cognitive pathway for consequences, motivational valuation behavioral responding consequences. These dynamic, not linear, with multiple possible trajectories between them, each sufficient produce persistence. We describe pathways, their characteristics, brain cellular circuit substrates, highlight relevance different self- treatment-guided behavior change.

Language: Английский

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Covalent organic polymer/chitosan multifunctional granular aerogels for diclofenac sodium removal from water

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 492, P. 152334 - 152334

Published: May 17, 2024

Language: Английский

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