Life Sciences,
Journal Year:
2023,
Volume and Issue:
320, P. 121558 - 121558
Published: March 6, 2023
Glioma
is
the
most
common
tumor
of
primary
central
nervous
system,
and
its
malignant
phenotype
has
been
shown
to
be
closely
related
glioma
stem
cells
(GSCs).
Although
temozolomide
significantly
improved
therapeutic
outcome
with
a
high
penetration
rate
blood-brain
barrier,
resistance
often
present
in
patients.
Moreover,
evidence
that
crosstalk
between
GSCs
tumor-associated
microglia/macrophages
(TAMs)
affect
clinical
occurrence,
growth,
multi-tolerance
chemoradiotherapy
gliomas.
Here,
we
highlight
vital
roles
maintenance
stemness
ability
recruit
TAMs
microenvironment
promote
their
polarization
into
tumor-promoting
macrophages,
hence
providing
groundwork
for
future
research
new
treatment
strategies
cancer.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: March 15, 2023
Exosome
is
a
subgroup
of
extracellular
vesicles,
which
has
been
serving
as
an
efficient
therapeutic
tool
for
various
diseases.
Engineered
exosomes
are
the
sort
modified
with
surface
decoration
and
internal
molecules.
After
appropriate
modification,
engineered
able
to
deliver
antitumor
drugs
tumor
sites
efficiently
precisely
fewer
treatment-related
adverse
effects.
However,
there
still
exist
many
challenges
clinical
translation
exosomes.
For
instance,
what
sources
modification
strategies
could
endow
most
activity
poorly
understood.
Additionally,
how
choose
appropriately
in
different
therapies
another
unresolved
problem.
In
this
review,
we
summarized
characteristics
exosomes,
especially
spatial
temporal
properties.
concluded
recent
advances
cancer
fields,
including
sources,
isolation
technologies,
strategies,
labeling
imaging
methods
Furthermore,
applications
were
summarized,
such
photodynamic
therapy,
gene
immunotherapy.
Consequently,
above
provides
researchers
community
latest
ideas
on
exosome
new
direction
drug
development,
prospective
accelerate
cancer-targeted
therapy.
Journal of Clinical Investigation,
Journal Year:
2023,
Volume and Issue:
133(1)
Published: Jan. 2, 2023
Glioblastoma
(GBM)
is
the
most
aggressive
tumor
in
central
nervous
system
and
contains
a
highly
immunosuppressive
microenvironment
(TME).
Tumor-associated
macrophages
microglia
(TAMs)
are
dominant
population
of
immune
cells
GBM
TME
that
contribute
to
hallmarks,
including
immunosuppression.
The
understanding
TAMs
has
been
limited
by
lack
powerful
tools
characterize
them.
However,
recent
progress
on
single-cell
technologies
offers
an
opportunity
precisely
at
level
identify
new
TAM
subpopulations
with
specific
tumor-modulatory
functions
GBM.
In
this
Review,
we
discuss
heterogeneity
plasticity
summarize
current
TAM-targeted
therapeutic
potential
We
anticipate
use
followed
functional
studies
will
accelerate
development
novel
effective
therapeutics
for
patients.
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: July 20, 2023
Abstract
Extracellular
vesicles
(EVs)
are
nano-sized,
natural,
cell-derived
that
contain
the
same
nucleic
acids,
proteins,
and
lipids
as
their
source
cells.
Thus,
they
can
serve
natural
carriers
for
therapeutic
agents
drugs,
have
many
advantages
over
conventional
nanocarriers,
including
low
immunogenicity,
good
biocompatibility,
blood
–
brain
barrier
penetration,
capacity
gene
delivery.
This
review
first
introduces
classification
of
EVs
then
discusses
several
currently
popular
methods
isolating
purifying
EVs,
EVs-mediated
drug
delivery,
functionalization
carriers.
Thereby,
it
provides
new
avenues
development
EVs-based
strategies
in
different
fields
medicine.
Finally,
highlights
some
challenges
future
perspectives
with
regard
to
clinical
application
EVs.
Graphical
Molecules,
Journal Year:
2023,
Volume and Issue:
28(13), P. 5145 - 5145
Published: June 30, 2023
Cancer
continues
to
pose
a
severe
threat
global
health,
making
pursuing
effective
treatments
more
critical
than
ever.
Traditional
therapies,
although
pivotal
in
managing
cancer,
encounter
considerable
challenges,
including
drug
resistance,
poor
solubility,
and
difficulties
targeting
tumors,
specifically
limiting
their
overall
efficacy.
Nanomedicine's
application
cancer
therapy
signals
new
epoch,
distinguished
by
the
improvement
of
specificity,
efficacy,
tolerability
treatments.
This
review
explores
mechanisms
advantages
nanoparticle-mediated
delivery,
highlighting
passive
active
strategies.
Furthermore,
it
transformative
potential
nanomedicine
tumor
therapeutics,
delving
into
its
applications
across
various
treatment
modalities,
surgery,
chemotherapy,
immunotherapy,
radiotherapy,
photodynamic
photothermal
therapy,
gene
as
well
diagnosis
imaging.
Meanwhile,
outlook
therapeutics
is
discussed,
emphasizing
need
for
addressing
toxicity
concerns,
improving
delivery
strategies,
enhancing
carrier
stability
controlled
release,
simplifying
nano-design,
exploring
novel
manufacturing
technologies.
Overall,
integrating
holds
immense
revolutionizing
patient
outcomes.
Advances in Biology & Earth Sciences,
Journal Year:
2024,
Volume and Issue:
9(Special Issue), P. 11 - 34
Published: April 11, 2024
An
important
characteristic
of
cancer
is
aberrant
metabolism.
Drug
resistance,
stem
cells,
metastasis
and
tumorigenesis
are
all
significantly
impacted
by
abnormal
metabolism,
which
includes
enhanced
anabolic
pathways
aerobic
glycolysis.
The
Hippo
pathway,
Myc
PI3K/AKT
recognized
oncogenic
signaling
networks
that
control
the
expression
metabolic
genes
increase
level
activity
enzymes.
On
other
hand,
result
in
disruptions
to
internal
signal
transduction
providing
energy,
building
blocks
redox
capabilities
necessary
for
uncontrolled
cell
proliferation.
Studies
clinical
trials
being
carried
out
investigate
impact
minute
substances
or
dietary
modifications,
such
as
calorie
restriction,
fasting
intermittent
fasting,
on
inhibition
phenotypes
malignancies
remarkably
diverse,
much
like
genetic
variability.
Genetic
abnormalities
a
variety
signals
found
tumor
microenvironment
contribute
this
Therefore,
one
main
objectives
contemporary
therapies
overcome
plasticity.
This
overview
explains
relationships
between
biochemical
emphasizes
recent
research
properties
cancer.
We
also
present
fresh
justifications
upcoming
class
medications
target
an
our
latest
studies
progress
nanomedicine
disease
detection
at
tiny
nano-bio
interactions
biological
systems
nanoparticles.
Significant
field
has
been
accomplished
last
20
years.
However,
absence
thorough
knowledge
situation
makes
it
difficult
improve
overall
patient
survival
with
nanomedicine.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(17)
Published: April 20, 2023
Extracellular
vesicles
(EVs)
are
transport
secreted
by
living
cells
and
released
into
the
extracellular
environment.
Recent
studies
have
shown
that
EVs
serve
as
"messengers"
in
intercellular
inter-organismal
communication,
both
normal
pathological
processes.
EVs,
natural
nanocarriers,
can
deliver
bioactivators
therapy
with
their
endogenous
properties.
This
review
article
describes
engineering
of
sources,
isolation
method,
cargo
loading,
boosting
approach,
adjustable
targeting
EVs.
Furthermore,
summarizes
recent
progress
made
EV-based
delivery
systems
applications,
including
cancer,
cardiovascular
diseases,
liver,
kidney,
nervous
system
COVID-19
emphasizes
obstacles
challenges
therapies
possible
strategies.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(21)
Published: Feb. 14, 2024
Activation
of
the
cyclic
GMP-AMP
synthase-stimulator
interferon
genes
(cGAS-STING)
pathway
has
emerged
as
an
efficient
strategy
to
improve
therapeutic
outcomes
immunotherapy.
However,
"constantly
active"
mode
current
STING
agonist
delivery
strategies
typically
leads
off-target
toxicity
and
hyperimmunity.
To
address
this
critical
issue,
herein
a
metal-organic
frameworks-based
nanoagonist
(DZ@A7)
featuring
tumor-specific
near-infrared
(NIR)
light-enhanced
decomposition
is
constructed
for
precisely
localized
activation
photodynamic-metalloimmunotherapy.
The
engineered
enabled
generation
mitochondria-targeted
reactive
oxygen
species
under
NIR
irradiation
specifically
release
mitochondrial
DNA
(mtDNA)
inhibit
repair
nuclear
via
hypoxia-responsive
drugs.
Oxidized
tumor
mtDNA
serves
endogenous
danger-associated
molecular
pattern
that
activates
cGAS-STING
pathway.
Concurrently,
NIR-accelerated
zinc
ions
overloading
in
cancer
cells
further
enhance
cGAS
enzymatic
activity
through
metalloimmune
effects.
By
combining
synergistically
enhanced
triggered
by
irradiation,
facilitated
maturation
dendritic
infiltration
cytotoxic
T
lymphocytes
primary
eradication,
which
also
established
long-term
anti-tumor
immunity
suppress
metastasis.
Therefore,
developed
NIR-triggered,
agonist-free,
tandem-amplified
pathway,
thereby
offering
distinct
paradigm
Cell Death and Disease,
Journal Year:
2024,
Volume and Issue:
15(4)
Published: April 1, 2024
Abstract
Macrophages,
as
pivotal
cells
within
the
tumour
microenvironment,
significantly
influence
impact
of
and
reactions
to
treatments
for
solid
tumours.
The
rapid
evolution
bioengineering
technology
has
revealed
vast
potential
engineered
macrophages
in
immunotherapy,
disease
diagnosis,
tissue
engineering.
Given
this
landscape,
goal
harnessing
innovating
a
novel
strategy
immunotherapy
cannot
be
overstated.
diverse
strategies
realm
cancer
encompassing
macrophage
drug
delivery
systems,
chimeric
antigen
receptor
therapy,
synergistic
treatment
approaches
involving
bacterial
outer
membrane
vesicles
macrophages,
are
meticulously
examined
review.
These
methodologies
designed
enhance
therapeutic
efficacy
against
tumours,
particularly
those
that
drug-resistant
metastatic.
Collectively,
these
immunotherapies
poised
supplement
refine
current
paradigms,
thus
heralding
new
frontier
fight
malignant
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
30, P. 101443 - 101443
Published: Jan. 5, 2025
Glioblastoma
(GBM)
is
the
most
prevalent
primary
malignant
brain
tumor,
characterized
by
a
high
mortality
rate
and
poor
prognosis.
The
blood-brain
barrier
(BBB)
blood-tumor
(BTB)
present
significant
obstacles
to
efficacy
of
tumor-targeted
pharmacotherapy,
thereby
impeding
therapeutic
potential
numerous
candidate
drugs.
Targeting
delivery
adequate
doses
drug
across
BBB
treat
GBM
has
become
prominent
research
area
in
recent
years.
This
emphasis
driven
exploration
evaluation
diverse
technologies
for
with
some
already
undergoing
clinical
trials.
review
provides
thorough
overview
advancements
challenges
targeted
treatment.
It
specifically
emphasizes
systemic
administration
strategies
assess
their
limitations
Furthermore,
this
highlights
promising
future
directions
development
intelligent
systems
aimed
at
overcoming
current
enhancing
against
GBM.
These
not
only
support
foundational
on
but
also
offer
methodological
approaches
applications.
