Neutrophil extracellular traps in homeostasis and disease

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Sept. 20, 2024

Language: Английский

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Toll‐like receptors in health and disease

MedComm, Journal Year: 2024, Volume and Issue: 5(5)

Published: April 29, 2024

Toll-like receptors (TLRs) are inflammatory triggers and belong to a family of pattern recognition (PRRs) that central the regulation host protective adaptive immune responses. Activation TLRs in innate myeloid cells directs lymphocytes produce most appropriate effector responses eliminate infection maintain homeostasis body's internal environment. Inappropriate TLR stimulation can lead development general autoimmune diseases as well chronic acute inflammation, even cancer. Therefore, expected be targets for therapeutic treatment inflammation-related diseases, microbial infections, human cancers. This review summarizes recent discoveries molecular structural biology TLRs. The role different signaling pathways such diabetes, cardiovascular respiratory digestive cancers (oral, gastric, breast, colorectal) is highlighted new drugs related clinical treatments trials, providing an overview potential prospects TLR-related diseases.

Language: Английский

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A Versatile Passivated Protein‐Adsorption Platform for Rapid Healing of Vascular Stents by Modulating the Microenvironment

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(16)

Published: Jan. 4, 2024

Abstract Biodegradable stents have paved the way to treat coronary artery disease. However, rapid reendothelialization is required solve problems of mismatched degradation rates, localized inflammation, and insufficient biocompatibility. Herein, a novel passivated protein‐adsorption coating synthesized by coordination chelation, oxidation, cross‐linking, polymerization, deposition dopamine, (‐)‐epigallocatechin gallate (EGCG), copper ions (Cu 2+ ) using two‐electron oxidation. This exhibits hierarchical functionality, that is, at macroscale, its superhydrophilicity conveys antifouling ability; whereas microscale, active groups (quinone‐, amino‐, hydroxyphenyl aromatic ring) facilitate protein adsorption. Antifouling ability prevents acute thrombosis inflammation maintains initial microenvironment stability post‐implantation. The gradual endothelial cells (ECs) adhesion. Meanwhile, decomposition nitric oxide (NO) donors release NO catalyzed Cu , EGCG alleviates or oxidative stress damage, inflammatory responses, formation, excessive smooth muscle proliferation in stent microenvironment. provides favorable conditions for healthy growth ECs. study proposes strategy neointima formation comprising ECs on surfaces biodegradable depositing (polydopamine/EGCG/Cu), opening new possibilities efficient treatment

Language: Английский

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Gegen Qinlian decoction ameliorates TNBS-induced ulcerative colitis by regulating Th2/Th1 and Tregs/Th17 cells balance, inhibiting NLRP3 inflammasome activation and reshaping gut microbiota

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 328, P. 117956 - 117956

Published: Feb. 29, 2024

Language: Английский

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Kaempferol efficacy in metabolic diseases: Molecular mechanisms of action in diabetes mellitus, obesity, non-alcoholic fatty liver disease, steatohepatitis, and atherosclerosis

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116694 - 116694

Published: May 6, 2024

The incidence of metabolic diseases has progressively increased, which a negative impact on human health and life safety globally. Due to the good efficacy limited side effects, there is growing interest in developing effective drugs treat from natural compounds. Kaempferol (KMP), an important flavonoid, exists many vegetables, fruits, traditional medicinal plants. Recently, KMP received widespread attention worldwide due its potential treatment diseases. To promote basic research clinical application KMP, this review provides timely comprehensive summary pharmacological advances four molecular mechanisms action, including diabetes mellitus, obesity, non-alcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH), atherosclerosis. According research, shows remarkable therapeutic effects by regulating multiple signaling transduction pathways such as NF-κB, Nrf2, AMPK, PI3K/AKT, TLR4, ER stress. In addition, most recent literature KMP's source, pharmacokinetics studies, well toxicity are also discussed review, thus providing foundation evidence for further studies develop novel Collectively, our manuscript strongly suggested that could be promising candidate

Language: Английский

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Lactate and lactylation in cardiovascular diseases: current progress and future perspectives

Metabolism, Journal Year: 2024, Volume and Issue: 158, P. 155957 - 155957

Published: June 21, 2024

Language: Английский

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Association of systemic immune-inflammation index with all-cause and cardiovascular mortality among adults with depression: evidence from NHANES 2005–2018

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 8, 2025

The relationship between the systemic immune-inflammatory index (SII) and mortality of adults with depression is uncertain. This study included who were surveyed in National Health Nutrition Examination Survey (NHANES) from 2005 to 2018. Cox proportional hazards regression models compute hazard ratios (HR) 95% confidence intervals (CI) for mortality.The restricted cubic spline(RCS), Kaplan-Meier curve analysis, time-dependent ROC subgroup sensitivity analyses also used. A total 2442 final analysis(average age: 46.51 ± 0.44 years). During a median follow-up 89 months, there 302 all-cause deaths 74 cardiovascular deaths. fully adjusted model showed that an increment 100 unit SII corresponded increased HR 1.05(95% CI,1.02,1.08, p = 0.003) 1.06(95% CI,1.02,1.10, 0.004) mortality, respectively. RCS analysis indicated J-shape positive linear association exhibited excellent efficacy predicting at 1, 3, 5 10 years. Higher levels associated risk depression. Not applicable.

Language: Английский

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Mechanisms of wogonoside in the treatment of atherosclerosis based on network pharmacology, molecular docking, and experimental validation

BMC Complementary Medicine and Therapies, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 27, 2025

Atherosclerosis serves as the fundamental pathology for a variety of cardiovascular disorders, with its pathogenesis being closely tied to complex interplay among lipid metabolism, oxidative stress, and inflammation. Wogonoside is natural flavonoid extracted from Scutellaria baicalensis biological activities, including anti-inflammatory, hypolipidemic, cardiac function improvement properties. Despite these known effects, specific role wogonoside in context atherosclerosis remains be elucidated. To validate efficacy treatment investigate possible therapeutic mechanisms. Network pharmacology was used obtain core targets signaling pathways that may efficacious wogonoside, which were validated using molecular docking dynamics simulations. further pathway, we performed vivo experiments apolipoprotein E (ApoE)-/- mice. This included pathological morphology deposition analysis mouse aorta, serum level analysis, Elisa stress reactive oxygen species (ROS) fluorescence assay, immunohistochemical protein blot analysis. Predictions obtained has 31 targets, are mainly focused on such Toll-like receptor (TLR) pathway NF-kappa B (NF-κB ) pathway. Molecular simulations showed good binding properties targets. In experimental results significantly inhibited aortic inflammatory response deposition, reduced release levels total cholesterol (TC), triglycerides (TG), low-density-lipoprotein (LDL-C), oxidized low density (ox-LDL) free fatty acid (FFA), factors TNF-α, IL-1β, IL-6 ApoE-/- Further mechanism studies activation TLR4/NF-κB an effective drug monomer atherosclerosis, action related inhibition

Language: Английский

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Antimicrobial peptide biological activity, delivery systems and clinical translation status and challenges

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 7, 2025

Antibiotic resistance is currently one of the most significant threats to global public health and safety. And studies have found that over next 25 years, 39 million people will die directly 169 indirectly due antibiotic-resistant diseases. Consequently, development new types antimicrobial drugs urgently needed. Antimicrobial peptides (AMPs) constitute an essential component innate immune response in all organisms. They exhibit a distinctive mechanism action endows them with broad spectrum biological activities, including antimicrobial, antibiofilm, antiviral, anti-inflammatory effects. However, AMPs also present certain limitations, such as cytotoxicity, susceptibility protein hydrolysis, poor pharmacokinetic properties, which impeded their clinical application. The delivery systems can address these challenges by modifying AMP enabling precise, controlled release at site infection or disease. This review offers comprehensive analysis mechanisms advantages AMPs. systematically evaluate how emerging drug systems, nanoparticles hydrogels, enhance stability bioavailability AMPs, discussing both strengths limitations. Moreover, unlike previous reviews, this highlight recent clinically approved AMP-based those development, emphasizing key translating into practice. With perspectives, it hoped provide some insights overcoming translational barriers advancing

Language: Английский

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Detecting mitochondrial hypochlorous acid and viscosity in atherosclerosis models via NIR fluorescent probes

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 156, P. 108191 - 108191

Published: Jan. 20, 2025

Language: Английский

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