The occurrence and development mechanisms of esophageal stricture: state of the art review DOI Creative Commons
Fang Yang,

Yiwei Hu,

Zewen Shi

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 31, 2024

Abstract Background Esophageal strictures significantly impair patient quality of life and present a therapeutic challenge, particularly due to the high recurrence post-ESD/EMR. Current treatments manage symptoms rather than addressing disease's etiology. This review concentrates on mechanisms esophageal stricture formation recurrence, seeking highlight areas for potential intervention. Methods A literature search was conducted through PUBMED using terms: stricture, mucosal resection, submucosal dissection. Relevant articles were identified manual with reference lists reviewed additional articles. Results Preclinical studies data from animal suggest that may lead include overdifferentiation fibroblasts, inflammatory response is not healed in time, impaired epithelial barrier function, multimethod factors leading it. Dysfunction be initiating mechanism stricture. Achieving perfect in-epithelialization by tissue-engineered fabrication cell patches has been shown effective treatment prevention strictures. Conclusion The development involves three stages: structural damage (EEB), chronic inflammation, severe fibrosis, which dysfunction or EEB Re-epithelialization essential information will help clinicians scientists develop techniques treat future.

Language: Английский

Fibrosis: Types, Effects, Markers, Mechanisms for Disease Progression, and Its Relation with Oxidative Stress, Immunity, and Inflammation DOI Open Access
Samar A. Antar,

Nada A. Ashour,

Mohamed E. Marawan

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 4004 - 4004

Published: Feb. 16, 2023

Most chronic inflammatory illnesses include fibrosis as a pathogenic characteristic. Extracellular matrix (ECM) components build up in excess to cause or scarring. The fibrotic process finally results organ malfunction and death if it is severely progressive. Fibrosis affects nearly all tissues of the body. associated with inflammation, metabolic homeostasis, transforming growth factor-β1 (TGF-β1) signaling, where balance between oxidant antioxidant systems appears be key modulator managing these processes. Virtually every system, including lungs, heart, kidney, liver, can affected by fibrosis, which characterized an excessive accumulation connective tissue components. Organ frequently caused remodeling, also linked high morbidity mortality. Up 45% fatalities industrialized world are damage any organ. Long believed persistently progressing irreversible, has now been revealed very dynamic preclinical models clinical studies variety systems. pathways from and/or main topics this review. Furthermore, different organs their effects was discussed. Finally, we highlight many principal mechanisms fibrosis. These could considered promising targets for development potential therapies important human diseases.

Language: Английский

Citations

133
Protective Factors and the Pathogenesis of Complications in Diabetes DOI Creative Commons
Marc Gregory Yu, Daniel Gordin, Jialin Fu

et al.

Endocrine Reviews, Journal Year: 2023, Volume and Issue: 45(2), P. 227 - 252

Published: Aug. 25, 2023

Chronic complications of diabetes are due to myriad disorders numerous metabolic pathways that responsible for most the morbidity and mortality associated with disease. Traditionally, divided into those microvascular macrovascular origin. We suggest revising this antiquated classification vascular, parenchymal, hybrid (both vascular parenchymal) tissue origin, since profile ranges from involving only tissues mostly parenchymal organs. A major paradigm shift has occurred in recent years regarding pathogenesis complications, which focus shifted studies on risks interplay between risk protective factors. While factors clearly important development chronic diabetes, have established equally significant modulating severity complications. These responses may help explain differential even lack pathologies, some tissues. Nevertheless, despite growing number field, comprehensive reviews their mechanisms action not available. This review thus focused clinical, biochemical, molecular support idea endogenous factors, roles initiation progression diabetes. In addition, also aimed identify main needs field future studies.

Language: Английский

Citations

58
H3K18 lactylation promotes the progression of arsenite-related idiopathic pulmonary fibrosis via YTHDF1/m6A/NREP DOI

Peiwen Wang,

Daxiao Xie,

Tian Xiao

et al.

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 461, P. 132582 - 132582

Published: Sept. 19, 2023

Language: Английский

Citations

56
Mechanisms of assembly and remodelling of the extracellular matrix DOI
Alexandra Naba

Nature Reviews Molecular Cell Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Language: Английский

Citations

42
Cuproptosis Cell Death Molecular Events and Pathways to Liver Disease DOI Creative Commons
Yun Mao, Huilan Chen,

Weihan Zhu

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 883 - 894

Published: Jan. 1, 2025

Chronic liver disease ranks as the 11th leading cause of death worldwide, while hepatocellular carcinoma (HCC) is fourth cancer-related mortality, representing a substantial risk to public health. Over past few decades, global landscape chronic diseases, including hepatitis, metabolic dysfunction-associated steatotic (MASLD), fibrosis, and HCC, has undergone changes. Copper, vital trace element for human health, predominantly regulated by liver. Both copper deficiency excess can lead cellular damage dysfunction. Copper deposition genetic process copper-dependent cell associated with mitochondrial respiration, which cardiovascular IBD. However, roles overload cuproptosis in remain largely underexplored. This article examines recent studies on metabolism disease, investigating potential targeting ions therapeutic approach. The objective offer insights guidance future investigations this developing field study.

Language: Английский

Citations

2
Mechanisms of kidney fibrosis and routes towards therapy DOI
N. Yamashita, Rafael Kramann

Trends in Endocrinology and Metabolism, Journal Year: 2023, Volume and Issue: 35(1), P. 31 - 48

Published: Sept. 28, 2023

Language: Английский

Citations

32
Extracellular vesicles: emerging roles, biomarkers and therapeutic strategies in fibrotic diseases DOI Creative Commons
Junyan Zhu, Sicong Wang,

Dakai Yang

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: May 24, 2023

Abstract Extracellular vesicles (EVs), a cluster of cell-secreted lipid bilayer nanoscale particles, universally exist in body fluids, as well cell and tissue culture supernatants. Over the past years, increasing attention have been paid to important role EVs effective intercellular communicators fibrotic diseases. Notably, EV cargos, including proteins, lipids, nucleic acids, metabolites, are reported be disease-specific can even contribute fibrosis pathology. Thus, considered biomarkers for disease diagnosis prognosis. Emerging evidence shows that derived from stem/progenitor cells great prospects cell-free therapy various preclinical models diseases engineered improve targeting effectiveness their treatment. In this review, we will focus on biological functions mechanisms diseases, potential novel therapeutic strategies.

Language: Английский

Citations

30
Wharton’s jelly mesenchymal stem cells: a concise review of their secretome and prospective clinical applications DOI Creative Commons

Hana Drobiova,

Sardar Sindhu,

Rasheed Ahmad

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 11

Published: June 27, 2023

Accumulating evidence indicates that most primary Wharton’s jelly mesenchymal stem cells (WJ-MSCs) therapeutic potential is due to their paracrine activity, i.e., ability modulate microenvironment by releasing bioactive molecules and factors collectively known as secretome. These can either be released directly into the surrounding or embedded within membrane-bound extracellular nano-sized (usually 30–150 nm) messenger particles vesicles of endosomal origin with specific route biogenesis, exosomes carried relatively larger (100 nm–1 μm) formed outward blebbing plasma membrane called microvesicles (MVs); MVs are (EVs). The found in secretome various types, including cytokines, chemokines, cytoskeletal proteins, integrins, growth factors, angiogenic mediators, hormones, metabolites, regulatory nucleic acid molecules. As expected, performs different biological functions, such immunomodulation, tissue replenishment, cellular homeostasis, besides possessing anti-inflammatory anti-fibrotic effects. This review highlights current advances research on WJ-MSCs’ its prospective clinical applications.

Language: Английский

Citations

23
Fibrotic phenotype of IgG4-related disease DOI
Marco Lanzillotta, Emma Culver, Amita Sharma

et al.

The Lancet Rheumatology, Journal Year: 2024, Volume and Issue: 6(7), P. e469 - e480

Published: April 1, 2024

Language: Английский

Citations

12
Deciphering the fibrotic process: mechanism of chronic radiation skin injury fibrosis DOI Creative Commons
Yiren Wang,

Shouying Chen,

Shuilan Bao

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 15, 2024

This review explores the mechanisms of chronic radiation-induced skin injury fibrosis, focusing on transition from acute radiation damage to a fibrotic state. It reviewed cellular and molecular responses radiation, highlighting role myofibroblasts significant impact Transforming Growth Factor-beta (TGF-β) in promoting fibroblast-to-myofibroblast transformation. The delves into epigenetic regulation gene expression, contribution extracellular matrix proteins microenvironment, immune system context fibrosis. Additionally, it discusses potential biomaterials artificial intelligence medical research advance understanding treatment suggesting future directions involving bioinformatics personalized therapeutic strategies enhance patient quality life.

Language: Английский

Citations

11