Published: Jan. 1, 2025
Language: Английский
Cellular Signalling, Journal Year: 2024, Volume and Issue: 122, P. 111333 - 111333
Published: Aug. 3, 2024
Language: Английский
Citations
6
Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 20, 2024
Language: Английский
Citations
6
Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(2), P. 429 - 436
Published: Feb. 5, 2024
CircRNAs are a class of single-stranded RNAs characterized by covalently looped structures. Emerging advances have promoted our understanding circRNA biogenesis, nuclear export, biological functions, and functional mechanisms. Roles circRNAs in diverse diseases been increasingly recognized the past decade, with novel approaches bioinformatics analysis new strategies modulating levels, which made hot spot for therapeutic applications. Moreover, due to intrinsic features such as high stability, conservation, tissue-/stage-specific expression, believed be promising prognostic diagnostic markers diseases. Aiming cardiovascular disease (CVD), one leading causes mortality worldwide, we briefly summarize current circRNAs, provide recent progress functions mechanisms CVD, discuss future perspectives both research therapeutics based on existing knowledge.
Language: Английский
Citations
5
Chinese Medicine, Journal Year: 2023, Volume and Issue: 18(1)
Published: Dec. 10, 2023
Salvianolic acid B (Sal B), a water-soluble phenolic compound derived from Salvia miltiorrhiza Bunge, is commonly used in Traditional Chinese Medicine to treat cardiovascular disease. In our previous study, Sal protected against myocardial fibrosis induced by diabetic cardiomyopathy (DCM). This study aimed investigate the ameliorative effects and potential mechanisms of mitigating DCM.Various methods were on DCM vivo vitro. These included blood glucose measurement, echocardiography, HE staining, Masson's trichrome Sirius red cell proliferation assessment, determination hydroxyproline levels, immunohistochemical evaluation fibrosis-related protein expression (Collagen-I, Collagen-III, TGF-β1, p-Smad3, Smad3, Smad7, α-smooth muscle actin), analysis Smad7 gene expression, ubiquitin modification.The animal test results indicated that significantly improved cardiac function, inhibited collagen deposition phenotypic transformation, ameliorated upregulating thereby inhibiting TGF-β1 signaling pathway. addition, experiments demonstrated proliferation, migration, secretion fibroblasts (CFs) high (HG). decreased ubiquitination stabilized increasing CFs pathway, which may be mechanism mitigates DCM.This revealed can improve deubiquitinating stabilizing blocking
Language: Английский
Citations
12
Cell & Bioscience, Journal Year: 2023, Volume and Issue: 13(1)
Published: Dec. 15, 2023
Abstract In multicellular organisms, regulatory cell death is a crucial aspect of growth and development. Ferroptosis, which was postulated roughly ten years ago, mode that differs from apoptosis, autophagy, pyrodeath. This distinct pattern triggered by an imbalance between oxidants antioxidants strongly associated with the metabolism iron, lipids, amino acids, glutathione. A growing body research has implicated ferroptosis in incidence progression many organ traumas degenerative diseases. Recently, gained attention as mechanism underlying initiation development variety cardiovascular diseases, including myocardial ischemia/reperfusion injury, cardiomyopathy, arrhythmia, chemotherapy, Corona Virus-2-induced cardiac injury. Pharmacological therapies inhibit have great potential for management disorders. review discusses prevalence mechanisms ferroptosis, effect on immune system, significance therapeutic value regulating heart
Language: Английский
Citations
11
Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(2)
Published: March 1, 2024
Abstract Over the past decade, prevalence of diabetes has increased significantly worldwide, leading to an increase in vascular complications (VCD), such as diabetic cardiomyopathy (DCM), nephropathy (DN), and retinopathy (DR). Noncoding RNAs (ncRNAs), microRNAs (miRNAs), long (lncRNAs), circular (circRNAs), play a key role cellular processes, including pathophysiology VCD via pyroptosis. ncRNAs (e.g., miR‐17, lnc‐MEG3, lnc‐KCNQ1OT1) can regulate pyroptosis pancreatic β cells. Some are involved progression. For example, miR‐21, lnc‐KCNQ1OT1, lnc‐GAS5, lnc‐MALAT1 were reported DN DCM, lnc‐MIAT was identified DCM DR. Herein, this review aimed summarize recent research findings related ncRNAs‐mediated at onset progression VCD.
Language: Английский
Citations
4
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116631 - 116631
Published: April 25, 2024
Diabetes mellitus (DM) is a prevalent chronic disease in the 21st century due to increased lifespan and unhealthy lifestyle choices. Extensive research indicates that exercise can play significant role regulating systemic metabolism by improving energy mitigating various metabolic disorders, including DM. Irisin, well-known exerkine, was initially reported enhance expenditure indicating browning of white adipose tissue (WAT) through peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) signaling. In this review, we summarize potential mechanisms underlying beneficial effects Irisin on glucose dysmetabolism, reducing gluconeogenesis, enhancing insulin expenditure, promoting glycogenesis. Additionally, highlight Irisin's improve diabetic vascular diseases stimulating nitric oxide (NO) production, oxidative nitrosative stress, curbing inflammation, attenuating endothelial cell aging. Furthermore, discuss cardiomyopathy preventing cardiomyocyte loss myocardial hypertrophy fibrosis. Given promising functions managing diseases, targeting for therapeutic purposes could be fruitful avenue future clinical interventions.
Language: Английский
Citations
4
International Heart Journal, Journal Year: 2024, Volume and Issue: 65(4), P. 703 - 712
Published: July 12, 2024
This study aimed to evaluate the clinical value of circ_0008842 in acute myocardial infarction (AMI) and explore potential mechanisms.GSE149051 GSE160717 datasets analyze common differentially expressed circRNAs (coDEcircRNA) AMI. RT-qPCR analysis mRNA levels patients with ROC curve assesses diagnostic A cell model AMI was constructed by hypoxia-reoxygenation (H/R) -induced H9c2. Cell viability apoptosis were examined CCK-8 flow cytometry. Enzyme-linked immunosorbent assay used injury markers CK-MB cTnI secretion. Dual luciferase reporter assays validate binding miRNA. PPI network gene ontology Kyoto Encyclopedia Genes Genomes pathway enrichment reveal functions pathways targets from miRNA AMI.circ_0008842 is recognized as coDEcircRNA AMI-related databases. greatly lower miR-574-5p significantly higher than healthy individuals. a target circ_0008842. The sensitivity specificity for diagnosing 87.40% 83.50%, respectively. Overexpression inhibited H/R induced apoptosis, increased viability, decreased levels, which partially abrogated overexpression miR-574-5p. Calmodulin-like protein 4 (CALML4) most connected hub predicted genes.circ_0008842 biomarker participates regulating Our provides new insights into diagnosis
Language: Английский
Citations
4
Epigenetics, Journal Year: 2024, Volume and Issue: 19(1)
Published: July 17, 2024
Doxorubicin (DOX)-mediated cardiotoxicity can impair the clinical efficacy of chemotherapy, leading to heart failure (HF). Given importance circRNAs and miRNAs in HF, this paper intended delineate mechanism circular RNA 0006332 (circ -0,006,332)/microRNA (miR)-143/Toll-like receptor 2 (TLR2) axis doxorubicin (DOX)-induced HF. The binding miR-143 circ -0,006,332 TLR2 was assessed with dual-luciferase assay, between determined FISH, RIP, pull-down assays. and/or were overexpressed rats cardiomyocytes, followed by DOX treatment. In expression, cell viability, LDH release, ATP contents, levels IL-1β, IL-18, TNF-α, pyroptosis-related molecules examined. rats, cardiac function, serum enzymes, apoptosis, myocardial fibrosis, TLR2, detected. diminished expression bound downregulate expression. reduced augmented DOX-induced cardiomyocytes. inhibited cytotoxicity suppressing pyroptosis H9C2 dysfunction, levels, pyroptosis. Furthermore, overexpression blocked these effects on cardiomyocytes rats. Circ stimulates cardiomyocyte downregulating upregulating thus promoting injury.
Language: Английский
Citations
4
PubMed, Journal Year: 2025, Volume and Issue: 45(3), P. 587 - 594
Published: March 20, 2025
To explore the mechanism of Circ-MYOCD back-splicing and its regulatory role in myocardial hypertrophy. Sanger sequencing RNase R assays were performed to verify circularity stability Circ-MYOCD, whose subcellular distribution was determined by nuclear-cytoplasmic fractionation. Bioinformatics analysis mass spectrometry from pull-down conducted predict RNA-binding proteins (RBPs) interacting with Circ-MYOCD. In rat cardiomyocytes H9C2 cells, effects HNRNPH1 HNRNPL knockdown overexpression on evaluated. a cell model angiotensin II (Ang II)-induced hypertrophy, expression detected, progression hypertrophy assessed, effect analyzed. confirmed that junction primers could amplify correct sequence. fractionation showed stable predominantly localized cytoplasm. assay identified as RBPs significantly enhanced while inhibited back-splicing; obviously increased expressions markers ANP BNP, produced opposite effect. Ang II-induced which exhibited significant increase expression, decreased MYOCD lowered both BNP expressions. regulates influence
Language: Английский
Citations
0