Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Jan. 4, 2024
Abstract
This
study
was
conducted
to
assess
the
effect
of
Evodiae
Fructus
70%
ethanol
extract
(EFE)
on
pathology
atopic
dermatitis
using
in
vitro
and
vivo
models.
The
major
compounds
EFE
were
identified
by
ultra-performance
liquid
chromatography
with
tandem
mass
spectrometry
as
rutaecarpine,
evodiamine,
evodol,
dehydroevodiamine,
limonin,
synephrine,
evocarpine,
dihydroevocarpine,
hydroxyevodiamine.
significantly
decreased
chemokine
levels
tumor
necrosis
factor-α/interferon-γ-stimulated
HaCaT
cells.
In
house
dust
mite-treated
NC/Nga
mice,
topical
application
score,
epidermal
hyperplasia
thickening,
mast
cell
infiltration,
plasma
histamine
corticosterone.
Thymic
stromal
lymphopoietin,
CD4
+
T
cells,
interleukin-4,
intercellular
adhesion
molecule-1
expression
lesioned
skin
reduced
treated
mice.
mechanism
elucidated
transcriptome
analysis,
followed
experimental
validation
Western
blotting
down-regulated
activation
Janus
kinase
(JAK)-signal
transducers
activators
transcription
(STAT)
mitogen-activated
protein
kinases
(MAPK)
signaling
pathways
improves
dermatitis-like
symptoms
suppressing
inflammatory
mediators,
cytokines,
chemokines
regulating
JAK-STAT
MAPK
pathways,
suggesting
its
use
a
potential
agent
for
treatment
dermatitis.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(2), P. 200 - 200
Published: Feb. 7, 2024
Cancer
has
become
one
of
the
most
multifaceted
and
widespread
illnesses
affecting
human
health,
causing
substantial
mortality
at
an
alarming
rate.
After
cardiovascular
problems,
condition
a
high
occurrence
rate
ranks
second
in
terms
mortality.
The
development
new
drugs
been
facilitated
by
increased
research
deeper
understanding
mechanisms
behind
emergence
advancement
disease.
Numerous
preclinical
clinical
studies
have
repeatedly
demonstrated
protective
effects
natural
terpenoids
against
range
malignancies.
potential
bioactive
investigated
sources
for
their
chemopreventive
chemoprotective
properties.
In
practically
all
body
cells,
signaling
molecule
referred
to
as
signal
transducer
activator
transcription
3
(STAT3)
is
widely
expressed.
that
STAT3
regulates
its
downstream
target
genes,
including
Bcl-2,
Bcl-xL,
cyclin
D1,
c-Myc,
survivin,
promote
growth
differentiation,
cell
cycle
progression,
angiogenesis,
immune
suppression
addition
chemotherapy
resistance.
Researchers
viewed
primary
cancer
therapy
because
crucial
involvement
formation.
This
primarily
focuses
on
directly
indirectly
preventing
expression
tumor
cells.
By
explicitly
targeting
both
vitro
vivo
settings,
it
possible
explain
effect
malignant
this
study,
we
provide
complete
overview
transduction
processes,
carcinogenesis,
related
persistent
activation.
article
also
thoroughly
summarizes
inhibition
certain
terpenoid
phytochemicals,
which
strong
efficacy
several
models.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
14
Published: Jan. 3, 2024
Signal
transducer
and
activator
of
transcription
(STAT)
proteins,
pivotal
regulators
signaling
cascades,
undergo
activation
in
response
to
the
stimulation
cytokines
growth
factors,
participate
biological
processes,
including
inflammation,
immune
responses,
cell
proliferation,
differentiation.
During
process
pregnancy,
STAT
is
involved
regulating
embryonic
implantation,
endometrial
decidualization,
establishing
maintaining
maternal-fetal
tolerance.
Increasing
evidence
suggests
that
aberrant
contributes
occurrence
development
pregnancy
disorders,
repeated
implantation
failure
(RIF),
preeclampsia
(PE),
recurrent
spontaneous
abortion
(RSA),
preterm
birth
(PTB)
gestational
diabetes
mellitus
(GDM).
Elucidating
molecular
mechanisms
pathway
holds
promise
for
further
understanding
establishment
maintenance
normal
thereby
providing
potent
targets
strategic
avenues
prevention
management
ailments
associated
with
pregnancy.
In
this
review,
we
summarized
roles
its
related
regulatory
function
conclusion,
in-depth
research
on
mechanism
not
only
enhances
our
processes
but
also
offers
STAT-based
therapeutic
approaches
protect
women
from
burden
pregnancy-related
disorders.
Signal Transduction and Targeted Therapy,
Journal Year:
2025,
Volume and Issue:
10(1)
Published: Feb. 4, 2025
Abstract
As
a
highly
complex
organ
with
digestive,
endocrine,
and
immune-regulatory
functions,
the
liver
is
pivotal
in
maintaining
physiological
homeostasis
through
its
roles
metabolism,
detoxification,
immune
response.
Various
factors
including
viruses,
alcohol,
metabolites,
toxins,
other
pathogenic
agents
can
compromise
function,
leading
to
acute
or
chronic
injury
that
may
progress
end-stage
diseases.
While
sharing
common
features,
diseases
exhibit
distinct
pathophysiological,
clinical,
therapeutic
profiles.
Currently,
contribute
approximately
2
million
deaths
globally
each
year,
imposing
significant
economic
social
burdens
worldwide.
However,
there
no
cure
for
many
kinds
of
diseases,
partly
due
lack
thorough
understanding
development
these
Therefore,
this
review
provides
comprehensive
examination
epidemiology
characteristics
covering
spectrum
from
conditions
manifestations.
We
also
highlight
multifaceted
mechanisms
underlying
initiation
progression
spanning
molecular
cellular
levels
networks.
Additionally,
offers
updates
on
innovative
diagnostic
techniques,
current
treatments,
potential
targets
presently
under
clinical
evaluation.
Recent
advances
pathogenesis
hold
critical
implications
translational
value
novel
strategies.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(21), P. 4607 - 4607
Published: Oct. 30, 2023
Pentadecanoic
acid
(C15:0)
is
an
essential
odd-chain
saturated
fatty
with
broad
activities
relevant
to
protecting
cardiometabolic,
immune,
and
liver
health.
C15:0
activates
AMPK
inhibits
mTOR,
both
of
which
are
core
components
the
human
longevity
pathway.
To
assess
potential
for
enhance
processes
associated
healthspan,
we
used
cell-based
molecular
phenotyping
assays
compare
three
longevity-enhancing
candidates:
acarbose,
metformin,
rapamycin.
(n
=
36
in
10
12
cell
systems)
rapamycin
32
had
most
clinically
relevant,
dose-dependent
activities.
At
their
optimal
doses,
(17
µM)
(9
shared
24
across
systems,
including
anti-inflammatory
(e.g.,
lowered
MCP-1,
TNFα,
IL-10,
IL-17A/F),
antifibrotic,
anticancer
activities,
further
supported
by
previously
published
vitro
vivo
studies.
Paired
prior
demonstrated
abilities
target
pathways,
hallmarks
aging,
aging
rate
biomarkers,
type
2
diabetes,
heart
disease,
cancer,
nonalcoholic
our
results
support
as
nutrient
equivalent
to,
or
surpassing,
leading
candidate
compounds.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Oct. 26, 2023
Autoimmune
diseases
arise
from
atypical
immune
responses
that
attack
self-tissue
epitopes,
and
their
development
is
intricately
connected
to
the
disruption
of
JAK-STAT
signaling
pathway,
where
SOCS
proteins
play
crucial
roles.
Conditions
such
as
autoimmune
uveitis,
psoriasis,
lupus,
encephalitis
exhibit
system
dysfunctions
associated
with
dysregulation.
Emerging
therapeutic
strategies
utilize
inhibitors
mimetics
modulate
alleviate
manifestations.
Although
more
research
clinical
studies
are
required
assess
effectiveness,
safety
profiles,
potential
for
personalized
approaches
in
conditions,
show
promise
treatment
options.
This
review
explores
action,
future
prospects
JAK
agents
systemic
lupus
erythematosus,
encephalitis.
The
findings
underscore
importance
investigating
these
targeted
therapies
advance
options
individuals
suffering
diseases.
MedComm – Oncology,
Journal Year:
2024,
Volume and Issue:
3(1)
Published: March 1, 2024
Abstract
Janus
Kinases
(JAKs)
play
a
crucial
role
as
therapeutic
targets
for
various
cancers.
However,
the
current
JAK
inhibitors
(JAKi)
available
have
limited
benefits
due
to
their
lack
of
selectivity.
This
review
focuses
on
structural
analysis
elucidate
molecular
determinants
JAKs
specificity
and
discovery
design
selective
JAKi.
It
includes
descriptions
comparison
different
structures
binding
sites,
comparative
JAKi
modes,
detailed
interaction
fingerprints
(IFPs),
an
extensive
structure‐selectivity
relationship
(SSRs).
Moreover,
also
explores
challenges
possibilities
using
computational
structure‐based
methods
discovering
designing
Other
approaches,
such
targeting
pseudokinase
domain,
well
covalent
allosteric
designs,
are
covered.
Based
this
analysis,
key
corresponding
rational
medicinal
chemistry
strategies
proposed
facilitate
development
highly
Overall,
we
aim
enhance
understanding
explore
that
can
lead
effective
in
cancer
therapy,
thus
improving
prognosis
patients.
