The emotional impact of disrupted environmental contexts: Enrichment loss and coping profiles influence stress response recovery in Long–Evans rats DOI Creative Commons

Molly Kent,

Dmitry Kovalev,

Benjamin L. Hart

et al.

Journal of Neuroendocrinology, Journal Year: 2022, Volume and Issue: 34(7)

Published: June 22, 2022

With increasing rates of anxiety and mood disorders across the world, there is an unprecedented need for preclinical animal models to generate translational results humans experiencing disruptive emotional symptoms. Considering that life events resulting in a perception loss are correlated with depressive symptoms, enrichment-loss rodent model offers promise as stress-initiated psychiatric disorders. Additionally, predisposed temperament characteristics such coping styles have been found influence individual's stress response. Accordingly, male rats were profiled either consistent or flexible copers assigned one three environments: standard laboratory housing, enriched environment, environment exposure followed by downsizing cages (i.e., group). Throughout study, several behaviors assessed determine stress, social, reward-processing responses. To assess recovery response, fecal samples collected following swim 3-h increments trajectory corticosterone (CORT) dehydroepiandrosterone (DHEA) metabolite levels. Upon death, neural markers neuroplasticity including doublecortin, glial fibrillary acidic factor, brain-derived neurotrophic factor via immunohistochemistry. Results indicated animals continuous group had higher DHEA/CORT ratios (consistent adaptive responses past research); furthermore, exhibited blunted CORT response throughout assessments faster than copers. Standard housed less exploratory behavior open field task enriched, consumed more food rewards other groups. No differences observed. In sum, present study support research indicating consequences enrichment-loss, providing evidence represents valuable approach investigation neurobiological mechanisms contributing interindividual variability changing experiential landscapes.

Language: Английский

The impact of acute and chronic stress on gastrointestinal physiology and function: a microbiota–gut–brain axis perspective DOI Creative Commons
Sarah‐Jane Leigh, Friederike Uhlig, Lars Wilmes

et al.

The Journal of Physiology, Journal Year: 2023, Volume and Issue: 601(20), P. 4491 - 4538

Published: Sept. 27, 2023

The physiological consequences of stress often manifest in the gastrointestinal tract. Traumatic or chronic is associated with widespread maladaptive changes throughout gut, although comparatively little known about effects acute stress. Furthermore, these stress-induced gut may increase susceptibility to disorders and infection, impact critical features neural behavioural response by impairing gut-brain axis communication. Understanding mechanisms behind enteric nervous system circuitry, visceral sensitivity, barrier function, permeability, microbiota following an important research objective pathophysiological implications both neurogastroenterology psychiatry. Moreover, has emerged as a key aspect physiology sensitive In this review, we focus on different aspects tract including function well immune, humoral neuronal elements involved discuss evidence for role disorders. Existing gaps current literature are highlighted, possible avenues future integrated perspective have been suggested. A more complete understanding spatial temporal dynamics host microbial kinds stressors will enable full exploitation diagnostic therapeutic potential fast-evolving field host-microbiome interactions.

Language: Английский

Citations

47
The neuroimmune response during stress: A physiological perspective DOI Creative Commons
Hedva Haykin, Asya Rolls

Immunity, Journal Year: 2021, Volume and Issue: 54(9), P. 1933 - 1947

Published: Sept. 1, 2021

Language: Английский

Citations

61
Hypothalamus and Post-Traumatic Stress Disorder: A Review DOI Creative Commons
Payman Raise‐Abdullahi,

Morvarid Meamar,

Abbas Ali Vafaei

et al.

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(7), P. 1010 - 1010

Published: June 29, 2023

Humans have lived in a dynamic environment fraught with potential dangers for thousands of years. While fear and stress were crucial the survival our ancestors, today, they are mostly considered harmful factors, threatening both physical mental health. Trauma is highly stressful, often life-threatening event or series events, such as sexual assault, war, natural disasters, burns, car accidents. can cause pathological metaplasticity, leading to long-lasting behavioral changes impairing an individual’s ability cope future challenges. If individual vulnerable, tremendously traumatic may result post-traumatic disorder (PTSD). The hypothalamus critical initiating hormonal responses stressful stimuli via hypothalamic–pituitary–adrenal (HPA) axis. Linked prefrontal cortex limbic structures, especially amygdala hippocampus, acts central hub, integrating physiological aspects response. Consequently, hypothalamic functions been attributed pathophysiology PTSD. However, apart from well-known role HPA axis, also play different roles development PTSD through other pathways, including hypothalamic–pituitary–thyroid (HPT) hypothalamic–pituitary–gonadal (HPG) axes, well by secreting growth hormone, prolactin, dopamine, oxytocin. This review aims summarize current evidence regarding neuroendocrine hypothalamus, which correlated A better understanding could help develop treatments this debilitating condition.

Language: Английский

Citations

29
The neurophysiological consequences of racism-related stressors in Black Americans DOI
E. Kate Webb, Sierra Carter, Kerry J. Ressler

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 161, P. 105638 - 105638

Published: March 24, 2024

Language: Английский

Citations

11
What we talk about when we talk about trauma: Content overlap and heterogeneity in the assessment of trauma exposure DOI Creative Commons
Karen‐Inge Karstoft, Chérie Armour

Journal of Traumatic Stress, Journal Year: 2022, Volume and Issue: 36(1), P. 71 - 82

Published: Sept. 25, 2022

The accurate definition and assessment of trauma exposure is the foundation for replicable studies mental health problems following exposure. However, scales developed to assess might vary widely in terms item content; overlap; specifications intensity, frequency, duration, timing. We compared eight frequently used self-report measures address content overlap measurement heterogeneity. Combined, these 44 disparate exposures. Mean across was moderate (M = 0.41, range: 0.25-0.48 scales). Pairwise between ranged from .19 .59. found 18 exposures (40.9%) that were included one scale three (6.8%) all scales. Four five intensity or perceived danger, two four implications heterogeneity clinical research as well comparability replication trauma-related are discussed.

Language: Английский

Citations

33
Gut microbiota alterations promote traumatic stress susceptibility associated with p-cresol-induced dopaminergic dysfunctions DOI
Samuele Laudani, Sebastiano Alfio Torrisi, Silvia Alboni

et al.

Brain Behavior and Immunity, Journal Year: 2022, Volume and Issue: 107, P. 385 - 396

Published: Nov. 16, 2022

Language: Английский

Citations

33
Enacting biosocial complexity: Stress, epigenetic biomarkers and the tools of postgenomics DOI Creative Commons
Luca Chiapperino

Social Studies of Science, Journal Year: 2024, Volume and Issue: 54(4), P. 598 - 625

Published: Jan. 12, 2024

This article analyses attempts to enact complexity in postgenomic experimentations using the case of epigenetic research on biomarkers psychosocial stress. Enacting this means dissecting multiple so-called biosocial processes health differentiation face stressful experiences. To characterize enactments complexity, develops concepts

Language: Английский

Citations

7
A systematic review of individual, social, and societal resilience factors in response to societal challenges and crises DOI Creative Commons
Sarah K. Schäfer, Max Supke, Corinna Kausmann

et al.

Communications Psychology, Journal Year: 2024, Volume and Issue: 2(1)

Published: Oct. 5, 2024

Language: Английский

Citations

7
Early life stress and perceived social isolation influence how children use value information to guide behavior DOI Creative Commons
Karen E. Smith, Seth D. Pollak

Child Development, Journal Year: 2021, Volume and Issue: 93(3), P. 804 - 814

Published: Dec. 31, 2021

Abstract Learning the value of environmental signals and using that information to guide behavior is critical for survival. Stress in childhood may influence these processes, but how it does so still unclear. This study examined stressful event exposures perceived social isolation affect ability learn use 72 children (8–9 years; 29 girls; 65.3% White). Stressful did not learned information. But, with high were worse at These data suggest alterations used, rather than learned, be one mechanism linking early experiences later behaviors.

Language: Английский

Citations

38
Effects of a True Prophylactic Treatment on Hippocampal and Amygdala Synaptic Plasticity and Gene Expression in a Rodent Chronic Stress Model of Social Defeat DOI Open Access
Eric T. Winzenried, Anna C. Everett, Erin R. Saito

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(13), P. 11193 - 11193

Published: July 7, 2023

Post-traumatic stress disorder (PTSD) is a complex stress-related induced by exposure to traumatic that characterized symptoms of re-experiencing, avoidance, and hyper-arousal. While it widely accepted brain regions involved in emotional regulation memory—e.g., the amygdala hippocampus—are dysregulated PTSD, pathophysiology not well defined therefore, pharmacological interventions are extremely limited. Because hormones norepinephrine cortisol (corticosterone rats) heavily implicated disorder, we explored whether preemptively systemically antagonizing β-adrenergic glucocorticoid receptors with propranolol mifepristone sufficient mitigate pathological changes synaptic plasticity, gene expression, anxiety modified social defeat (SD) protocol. Young adult, male Sprague Dawley rats were initially pre-screened for anxiety. The then exposed SD chronic light induce anxiety-like symptoms. Drug-treated administered injections prior continuing throughout stress. Using competitive ELISAs on plasma, field electrophysiology at CA1 ventral hippocampus (VH) basolateral (BLA), quantitative RT-PCR, behavior assays, demonstrate our increased behavior, elevated long-term potentiation (LTP) VH BLA, altered expression mineralocorticoid, glucocorticoid, glutamate receptors. These measures largely reverted control levels administration mifepristone. Our findings indicate increases LTP BLA prophylactic treatment may have potential mitigating these other stress-induced effects.

Language: Английский

Citations

12