Consequences of Inadequate Caregiving for Children’s Attachment, Neurobiological Development, and Adaptive Functioning DOI
Stacia Bourne, Marta Korom, Mary Dozier

et al.

Clinical Child and Family Psychology Review, Journal Year: 2022, Volume and Issue: 25(1), P. 166 - 181

Published: Feb. 24, 2022

Language: Английский

Psychedelic Treatments in Adolescent Psychopharmacology: Considering Safety, Ethics, and Scientific Rigor DOI

Isabella Sutherland,

Ming‐Fen Ho, Paul E. Croarkin

et al.

Journal of Child and Adolescent Psychopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Interest in psychedelic therapies for adults is rapidly growing, with substances like 3,4-methylenedioxymethamphetamine posttraumatic stress disorder, psilocybin treatment-resistant depression, and lysergic acid diethylamide generalized anxiety disorder showing promise. However, research on these children adolescents limited, no recent trials. Despite this lack of scientific exploration, may still experiment both recreational therapeutic purposes as accessibility continues to increase. This raises significant concerns, are a vulnerable population requiring heightened caution safety measures. Therefore, we advocate structured, safe, well-controlled exploration adolescents.

Language: Английский

Citations

3
From neural circuits to communities: an integrative multidisciplinary roadmap for global mental health DOI Open Access
Michelle G. Craske, Mohammad M. Herzallah, Robin Nusslock

et al.

Nature Mental Health, Journal Year: 2023, Volume and Issue: 1(1), P. 12 - 24

Published: Jan. 17, 2023

Language: Английский

Citations

25
The gut microbiota, HPA axis, and brain in adolescent-onset depression: Probiotics as a novel treatment DOI Creative Commons
Daniel Freimer, Tony T. Yang, Tiffany C. Ho

et al.

Brain Behavior & Immunity - Health, Journal Year: 2022, Volume and Issue: 26, P. 100541 - 100541

Published: Oct. 30, 2022

Stress-associated disruptions in the development of frontolimbic regions may play a critical role emergence adolescent-onset depression. These are particularly sensitive to Hypothalamic-Pituitary-Adrenal (HPA) axis signaling. The HPA is hyperactive adolescent depression, and interventions that attenuate such hyperactivity hold promise as potential treatments. Microbiome-Gut-Brain (MGB) an important pathway through which stress dysregulates HPA-axis activity thus exerts deleterious effects on brain. Probiotic agents, alter gut microbiota composition by introducing bacterial strains with beneficial physiological effects, normalize aberrant reduce depressive symptoms both animal studies adult clinical trials. While utility agents treating or preventing depression remains largely unexplored, recent data suggest existence window during probiotics be especially efficacious reducing compared observed populations. In this review, we outline evidence probiotic use development, providing novel means improving among

Language: Английский

Citations

30
Interpersonal early adversity demonstrates dissimilarity from early socioeconomic disadvantage in the course of human brain development: A meta-analysis DOI Creative Commons
Anna Vannucci, Andrea Fields, Eleanor Hansen

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 150, P. 105210 - 105210

Published: May 3, 2023

Language: Английский

Citations

18
Dimensions of childhood adversity differentially affect biological aging in major depression DOI Creative Commons
Ryan Rampersaud, Ekaterina Protsenko, Ruoting Yang

et al.

Translational Psychiatry, Journal Year: 2022, Volume and Issue: 12(1)

Published: Oct. 4, 2022

Abstract Adverse childhood experiences have been consistently linked with physical and mental health disorders in adulthood that may be mediated, part, via the effects of such exposures on biological aging. Using recently developed “epigenetic clocks”, which provide an estimate age, several studies demonstrated a link between cumulative exposure to adversities accelerated epigenetic However, not all are equivalent less is known about how distinct dimensions adversity relate aging metrics. two measures exposure, we assess Maltreatment Household Dysfunction using “second-generation” clocks, GrimAge PhenoAge, cohort unmedicated somatically healthy adults moderate severe major depression ( n = 82). Our results demonstrate dimension associated age acceleration (EAA) PhenoAge but clock. This association was observed both Childhood Trauma questionnaire (CTQ; β 0.272, p 0.013 ) Experiences (ACEs) (β 0.307, 0.005 remained significant when adjusting for 0.322, 0.009 ). In contrast, deceleration −0.194, 0.083 achieved significance after −0.304, 0.022 study first investigate these among individuals Major Depressive Disorder suggests disease mechanisms.

Language: Английский

Citations

25
The body keeps the score: The neurobiological profile of traumatized adolescents DOI Creative Commons
Daniela Laricchiuta,

Anna Panuccio,

Eleonora Picerni

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 145, P. 105033 - 105033

Published: Jan. 4, 2023

Trauma-related disorders are debilitating psychiatric conditions that affect people who have directly or indirectly witnessed adversities. Experiencing multiple types of traumas appears to be common during childhood, and even more so adolescence. Dramatic brain/body transformations occurring adolescence may provide a highly responsive substrate external stimuli lead trauma-related vulnerability conditions, such as internalizing (anxiety, depression, anhedonia, withdrawal) externalizing (aggression, delinquency, conduct disorders) problems. Analyzing relations among neuronal, endocrine, immune, biochemical signatures trauma behaviors, including the role personality traits in shaping these conducts, this review highlights marked effects traumatic experience on involve changes at nearly every level analysis, from brain structure, function connectivity endocrine immune systems, gene expression (including gut) development personality.

Language: Английский

Citations

16
Early adolescent development in the face of violence: A systematic review running DOI
Emma Jagasia,

India Bloom,

Katie E. Nelson

et al.

Child Abuse & Neglect, Journal Year: 2024, Volume and Issue: 151, P. 106751 - 106751

Published: March 25, 2024

Language: Английский

Citations

4
Do dimensions of childhood adversity differ in their direct associations with youth psychopathology? A meta-analysis DOI Creative Commons
Amy Hyoeun Lee, Yukihiro Kitagawa, Rebecca Mirhashem

et al.

Development and Psychopathology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 31

Published: April 8, 2024

Growing evidence supports the unique pathways by which threat and deprivation, two core dimensions of adversity, confer risk for youth psychopathology. However, extent to these differ in their direct associations with psychopathology remains unclear. The primary aim this preregistered meta-analysis was synthesize between threat, internalizing, externalizing, trauma-specific Because is proposed be directly linked socioemotional development, we hypothesized that magnitude would larger than those deprivation. We conducted a search peer-reviewed articles English using PubMed PsycINFO databases through August 2022. Studies assessed both deprivation used previously validated measures were included. One hundred twenty-seven included synthesis (

Language: Английский

Citations

4
Early life stress and brain development: Neurobiological and behavioral effects of chronic stress DOI
Subia Jamil, Muhammad Liaquat Raza, Nasrollah Moradikor

et al.

Progress in brain research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Multivariate links between the developmental timing of adversity exposure and white matter tract connectivity in adulthood DOI
Lucinda M. Sisk, Taylor J. Keding, Emily M. Cohodes

et al.

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0