Frontiers in Psychology,
Journal Year:
2022,
Volume and Issue:
13
Published: March 3, 2022
Childhood
adversity
is
associated
with
altered
or
dysregulated
stress
reactivity;
these
patterns
of
physiological
functioning
persist
into
adulthood.
Evidence
from
both
preclinical
animal
models
and
human
neuroimaging
studies
indicates
that
early
life
experience
differentially
influences
stressor-evoked
activity
within
central
visceral
neural
circuits
proximally
involved
in
the
control
responses,
including
subgenual
anterior
cingulate
cortex
(sgACC),
paraventricular
nucleus
hypothalamus
(PVN),
bed
stria
terminalis
(BNST)
amygdala.
However,
relationship
between
childhood
resting-state
connectivity
this
network
remains
unclear.
To
end,
we
examined
relationships
threat
socioeconomic
deprivation,
our
regions
interest
(ROIs),
affective
symptom
severity
diagnoses.
We
recruited
a
transdiagnostic
sample
young
adult
males
females
(
n
=
100;
mean
age
27.28,
SD
3.99;
59
females)
full
distribution
maltreatment
history
across
multiple
disorders.
Resting-state
data
were
acquired
using
7.2-min
functional
magnetic
resonance
imaging
(fMRI)
sequence;
noted
ROIs
applied
as
masks
to
determine
ROI-to-ROI
connectivity.
Threat
was
determined
by
measures
traumatic
events
abuse.
Socioeconomic
deprivation
(SED)
measure
status
(parental
education
level).
Covarying
for
age,
race
sex,
greater
significantly
lower
BNST-PVN,
amygdala-sgACC
PVN-sgACC
No
significant
found
SED
BNST-PVN
number
lifetime
Exposure
during
development
may
entrain
stress-related
ways
contribute
responses
subsequent
psychopathology.
Journal of Child and Adolescent Psychopharmacology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 6, 2025
Interest
in
psychedelic
therapies
for
adults
is
rapidly
growing,
with
substances
like
3,4-methylenedioxymethamphetamine
posttraumatic
stress
disorder,
psilocybin
treatment-resistant
depression,
and
lysergic
acid
diethylamide
generalized
anxiety
disorder
showing
promise.
However,
research
on
these
children
adolescents
limited,
no
recent
trials.
Despite
this
lack
of
scientific
exploration,
may
still
experiment
both
recreational
therapeutic
purposes
as
accessibility
continues
to
increase.
This
raises
significant
concerns,
are
a
vulnerable
population
requiring
heightened
caution
safety
measures.
Therefore,
we
advocate
structured,
safe,
well-controlled
exploration
adolescents.
Brain Behavior & Immunity - Health,
Journal Year:
2022,
Volume and Issue:
26, P. 100541 - 100541
Published: Oct. 30, 2022
Stress-associated
disruptions
in
the
development
of
frontolimbic
regions
may
play
a
critical
role
emergence
adolescent-onset
depression.
These
are
particularly
sensitive
to
Hypothalamic-Pituitary-Adrenal
(HPA)
axis
signaling.
The
HPA
is
hyperactive
adolescent
depression,
and
interventions
that
attenuate
such
hyperactivity
hold
promise
as
potential
treatments.
Microbiome-Gut-Brain
(MGB)
an
important
pathway
through
which
stress
dysregulates
HPA-axis
activity
thus
exerts
deleterious
effects
on
brain.
Probiotic
agents,
alter
gut
microbiota
composition
by
introducing
bacterial
strains
with
beneficial
physiological
effects,
normalize
aberrant
reduce
depressive
symptoms
both
animal
studies
adult
clinical
trials.
While
utility
agents
treating
or
preventing
depression
remains
largely
unexplored,
recent
data
suggest
existence
window
during
probiotics
be
especially
efficacious
reducing
compared
observed
populations.
In
this
review,
we
outline
evidence
probiotic
use
development,
providing
novel
means
improving
among
Translational Psychiatry,
Journal Year:
2022,
Volume and Issue:
12(1)
Published: Oct. 4, 2022
Abstract
Adverse
childhood
experiences
have
been
consistently
linked
with
physical
and
mental
health
disorders
in
adulthood
that
may
be
mediated,
part,
via
the
effects
of
such
exposures
on
biological
aging.
Using
recently
developed
“epigenetic
clocks”,
which
provide
an
estimate
age,
several
studies
demonstrated
a
link
between
cumulative
exposure
to
adversities
accelerated
epigenetic
However,
not
all
are
equivalent
less
is
known
about
how
distinct
dimensions
adversity
relate
aging
metrics.
two
measures
exposure,
we
assess
Maltreatment
Household
Dysfunction
using
“second-generation”
clocks,
GrimAge
PhenoAge,
cohort
unmedicated
somatically
healthy
adults
moderate
severe
major
depression
(
n
=
82).
Our
results
demonstrate
dimension
associated
age
acceleration
(EAA)
PhenoAge
but
clock.
This
association
was
observed
both
Childhood
Trauma
questionnaire
(CTQ;
β
0.272,
p
0.013
)
Experiences
(ACEs)
(β
0.307,
0.005
remained
significant
when
adjusting
for
0.322,
0.009
).
In
contrast,
deceleration
−0.194,
0.083
achieved
significance
after
−0.304,
0.022
study
first
investigate
these
among
individuals
Major
Depressive
Disorder
suggests
disease
mechanisms.
Neuroscience & Biobehavioral Reviews,
Journal Year:
2023,
Volume and Issue:
145, P. 105033 - 105033
Published: Jan. 4, 2023
Trauma-related
disorders
are
debilitating
psychiatric
conditions
that
affect
people
who
have
directly
or
indirectly
witnessed
adversities.
Experiencing
multiple
types
of
traumas
appears
to
be
common
during
childhood,
and
even
more
so
adolescence.
Dramatic
brain/body
transformations
occurring
adolescence
may
provide
a
highly
responsive
substrate
external
stimuli
lead
trauma-related
vulnerability
conditions,
such
as
internalizing
(anxiety,
depression,
anhedonia,
withdrawal)
externalizing
(aggression,
delinquency,
conduct
disorders)
problems.
Analyzing
relations
among
neuronal,
endocrine,
immune,
biochemical
signatures
trauma
behaviors,
including
the
role
personality
traits
in
shaping
these
conducts,
this
review
highlights
marked
effects
traumatic
experience
on
involve
changes
at
nearly
every
level
analysis,
from
brain
structure,
function
connectivity
endocrine
immune
systems,
gene
expression
(including
gut)
development
personality.
Development and Psychopathology,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 31
Published: April 8, 2024
Growing
evidence
supports
the
unique
pathways
by
which
threat
and
deprivation,
two
core
dimensions
of
adversity,
confer
risk
for
youth
psychopathology.
However,
extent
to
these
differ
in
their
direct
associations
with
psychopathology
remains
unclear.
The
primary
aim
this
preregistered
meta-analysis
was
synthesize
between
threat,
internalizing,
externalizing,
trauma-specific
Because
is
proposed
be
directly
linked
socioemotional
development,
we
hypothesized
that
magnitude
would
larger
than
those
deprivation.
We
conducted
a
search
peer-reviewed
articles
English
using
PubMed
PsycINFO
databases
through
August
2022.
Studies
assessed
both
deprivation
used
previously
validated
measures
were
included.
One
hundred
twenty-seven
included
synthesis
(
International Journal of Obesity,
Journal Year:
2024,
Volume and Issue:
48(8), P. 1157 - 1163
Published: May 30, 2024
Childhood
adversity
has
previously
been
associated
with
overweight
and
obesity
in
adult
life,
but
there
is
a
need
for
larger
population-based
studies
using
prospectively
obtained
trajectories
across
childhood
to
confirm
these
associations.
Moreover,
may
also
be
underweight,
which
less
often
studied.
The
aim
of
the
current
study
investigate
association
between
from
0-15
years
weight
categories
young
men.