mPFC DCC coupling with CaMKII+ neuronal excitation participates in behavioral despair in male mice DOI Creative Commons

Ping Cheng,

Keke Ding,

Daokang Chen

et al.

Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 14, 2025

A longed lack of control over harmful stimuli can lead to learned helplessness (LH), a significant factor in depression. However, the cellular and molecular mechanisms underlying LH, eventually behavioral despair, remain largely unknown. The deleted colorectal cancer (dcc) gene is associated with risk therapeutic potential regulation mechanism DCC despair are still uncertain. In this study, we showed that depressive stimulators, including lipopolysaccharide, unpredictable chronic mild stress, triggered an elevation expression medial prefrontal cortex (mPFC). Additionally, elevated mPFC was crucial inducing as evidenced by induction normal mice exacerbation LH upon overexpression. By contrast, neutralizing activity ameliorated LH-induced despair. Importantly, elucidated pathological attributable excessive excitation CaMKII+ neurons manner dependent on calpain-mediated degradation SCOP aberrant phosphorylation ERK signaling pathway. addition, increase led decreased excitability threshold mPFC, which supported observation ligand netrin 1 increased frequency action firing spontaneous excitatory postsynaptic currents neurons. conclusion, our data indicate triggers activation calpain-SCOP/ERK promote expression, represents target for treatment male mice.

Language: Английский

Selecting an Appropriate Animal Model of Depression DOI Open Access
Yuanzheng Hao, Huixiang Ge,

Mengyun Sun

et al.

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(19), P. 4827 - 4827

Published: Sept. 28, 2019

Depression has become one of the most severe psychiatric disorders and endangers health living beings all over world. In order to explore molecular mechanism that underlies depression, different kinds animal models depression are used in laboratory experiments. However, a credible reasonable model is capable imitating pathologic mankind yet be found, resulting barrier further investigation depression. Nevertheless, it possible explain great extent by rational modeling method behavioral testing. This review aims provide reference for researchers comparing advantages disadvantages some common models.

Language: Английский

Citations

193
Polygonatum sibiricum polysaccharide prevents depression-like behaviors by reducing oxidative stress, inflammation, and cellular and synaptic damage DOI

Fengming Shen,

Zhujin Song,

Pan Xie

et al.

Journal of Ethnopharmacology, Journal Year: 2021, Volume and Issue: 275, P. 114164 - 114164

Published: April 28, 2021

Language: Английский

Citations

124
Curculigoside inhibits ferroptosis in ulcerative colitis through the induction of GPX4 DOI
Shujun Wang, Wei Liu, Jin Wang

et al.

Life Sciences, Journal Year: 2020, Volume and Issue: 259, P. 118356 - 118356

Published: Aug. 28, 2020

Language: Английский

Citations

124
Ginsenoside Rg1 Prevents PTSD-Like Behaviors in Mice Through Promoting Synaptic Proteins, Reducing Kir4.1 and TNF-α in the Hippocampus DOI Open Access
Zhengrong Zhang,

Zhujin Song,

Fengming Shen

et al.

Molecular Neurobiology, Journal Year: 2020, Volume and Issue: 58(4), P. 1550 - 1563

Published: Nov. 19, 2020

Language: Английский

Citations

72
cAMP-PKA cascade: An outdated topic for depression? DOI Open Access
Feng Gao, Shaojie Yang, Juan Wang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 150, P. 113030 - 113030

Published: April 26, 2022

Depression is a common neuropsychiatric disorder characterized by persistent depressed mood and causes serious socioeconomic burden worldwide. Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis, deficiency monoamine transmitters, neuroinflammation abnormalities gut flora are strongly associated with onset depression. The cyclic AMP (cAMP)/protein kinase A (PKA) cascade, major cross-species cellular signaling pathway, supposed as important player regulator depression controlling synaptic plasticity, cytokinesis, transcriptional regulation HPA axis. In central nervous system, cAMP-PKA cascade can dynamically shape neural circuits enhancing affect K+ channels phosphorylating Kir4.1, thereby regulating neuronal excitation. reduction affects excitation well ultimately leading to pathological outcome depression, while activation would provide rapid antidepressant effect. this review, we proposed reconsider function especially in Local or indirect PKA through adjusting anchor proteins new idea for acute treatment

Language: Английский

Citations

54
Astragalus species: Phytochemistry, biological actions and molecular mechanisms underlying their potential neuroprotective effects on neurological diseases DOI
Heba‐Tallah Abd Elrahim Abd Elkader, Amina E. Essawy, Ahmed S. Al‐Shami

et al.

Phytochemistry, Journal Year: 2022, Volume and Issue: 202, P. 113293 - 113293

Published: June 30, 2022

Language: Английский

Citations

44
Utility of 7,8-dihydroxyflavone in preventing astrocytic and synaptic deficits in the hippocampus elicited by PTSD DOI
Juan Wang, Feng Gao, Shuai Cui

et al.

Pharmacological Research, Journal Year: 2022, Volume and Issue: 176, P. 106079 - 106079

Published: Jan. 10, 2022

Language: Английский

Citations

42
Polysaccharides from Polygonatum cyrtonema Hua prevent post-traumatic stress disorder behaviors in mice: Mechanisms from the perspective of synaptic injury, oxidative stress, and neuroinflammation DOI

Pan Xie,

Lixia Chen, Juan Wang

et al.

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 319, P. 117165 - 117165

Published: Sept. 9, 2023

Language: Английский

Citations

35
AKT and MAPK signaling pathways in hippocampus reveals the pathogenesis of depression in four stress-induced models DOI Creative Commons
Xuemei Li, Teng Teng, Wei Yan

et al.

Translational Psychiatry, Journal Year: 2023, Volume and Issue: 13(1)

Published: June 12, 2023

Abstract Major depressive disorder (MDD) is a highly heterogeneous psychiatric disorder. The pathogenesis of MDD remained unclear, and it may be associated with exposure to different stressors. Most previous studies have focused on molecular changes in single stress-induced depression model, which limited the identification MDD. depressive-like behaviors were induced by four well-validated stress models rats, including chronic unpredictable mild stress, learned helplessness restraint social defeat stress. We applied proteomic metabolomic investigate hippocampus those revealed 529 proteins 98 metabolites. Ingenuity Pathways Analysis (IPA) Kyoto Encyclopedia Genes Genomes (KEGG) analysis identified differentially regulated canonical pathways, then we presented schematic model that simulates AKT MAPK signaling pathways network their interactions cascade reactions. Further, western blot confirmed p-AKT, p-ERK12, GluA1, p-MEK1, p-MEK2, p-P38, Syn1, TrkB, changed at least one model. Importantly, p-MEK1 p-P38 as common alterations models. level caused stressors dramatically different, even opposite, between However, converge pathway. Further these could contribute better understanding depression, ultimate goal helping develop or select more effective treatment strategies for

Language: Английский

Citations

26
Exploring the effect of Anshen Dingzhi prescription on hippocampal mitochondrial signals in single prolonged stress mouse model DOI
Juan Wang, Panpan Zhao,

Ping Cheng

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 323, P. 117713 - 117713

Published: Jan. 4, 2024

Language: Английский

Citations

14