Inflammation, Journal Year: 2024, Volume and Issue: unknown
Published: May 13, 2024
Language: Английский
Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)
Published: March 14, 2023
Doxorubicin (DOX) is a powerful and commonly used chemotherapeutic drug, alone or in combination variety of cancers, while it has been found to cause serious cardiac side effects clinical application. More more researchers are trying explore the molecular mechanisms DOX-induced cardiomyopathy (DIC), which oxidative stress inflammation considered play significant role. This review summarizes signaling pathways related DIC compounds that exert cardioprotective by acting on relevant pathways, including role Nrf2/Keap1/ARE, Sirt1/p66Shc, Sirt1/PPAR/PGC-1α NOS, NOX, Fe2+ stress, as well NLRP3/caspase-1/GSDMD, HMGB1/TLR4/MAPKs/NF-κB, mTOR/TFEB/NF-κB inflammation. Hence, we attempt explain terms inflammation, provide theoretical basis new idea for further drug research reducing DIC. Video Abstract.
Language: Английский
Citations
111
Advanced Science, Journal Year: 2023, Volume and Issue: 10(26)
Published: July 12, 2023
In recent years, the incidence of gastrointestinal cancers is increasing, particularly in younger population. Effective treatment crucial for improving patients' survival outcomes. Programmed cell death, regulated by various genes, plays a fundamental role growth and development organisms. It also critical maintaining tissue organ homeostasis takes part multiple pathological processes. addition to apoptosis, there are other types programmed such as ferroptosis, necroptosis, pyroptosis, which can induce severe inflammatory responses. Notably, besides pyroptosis contribute occurrence cancers. This review aims provide comprehensive summary on biological roles molecular mechanisms well their regulators hope open up new paths tumor targeted therapy near future.
Language: Английский
Citations
44
Light Science & Applications, Journal Year: 2025, Volume and Issue: 14(1)
Published: Jan. 2, 2025
Abstract The microenvironment of immunosuppression and low immunogenicity tumor cells has led to unsatisfactory therapeutic effects the currently developed nanoplatforms. Immunogenic cell death, such as pyroptosis ferroptosis, can efficiently boost antitumor immunity. However, exploration nanoplatform for dual function inducers combined immune activators that simultaneously trigger ferroptosis remains limited. Herein, a multifunctional pH-responsive theranostic (M@P) is designed constructed by self-assembly aggregation-induced emission photosensitizer MTCN-3 immunoadjuvant Poly(I: C), which are further encapsulated in amphiphilic polymers. This found have characteristics cancer targeting, pH response, near-infrared fluorescence imaging, lysosome targeting. Therefore, after targeting lysosomes, M@P cause dysfunction through generation reactive oxygen species heat under light irradiation, triggering cells, achieving immunogenic enhancing immunotherapy effect with C). anti-tumor been demonstrated vivo experiment 4T1 tumor-bearing mouse model poor immunogenicity. research would provide an impetus well novel strategy enhanced photoimmunotherapy.
Language: Английский
Citations
5
Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13
Published: Sept. 30, 2022
Pyroptosis is a relatively newly discovered programmed cell death accompanied by an inflammatory response. In the classical view, pyroptosis mediated caspases-1,-4,-5,-11 and executed GSDMD, however, recently it was demonstrated that caspase-3 and-8 also participate in process of pyroptosis, cleaving GSDMD/E GSDMD respectively. Different from autophagy apoptosis, many pores are formed on membrane during which makes lose its integrity, eventually leading to release cytokines interleukin(IL)-1β IL-18. When body infected with pathogens or exposed some stimulations, could play immune defense role. It found exists widely infectious respiratory diseases such as acute lung injury, bronchial dysplasia, chronic obstructive pulmonary disease, asthma. Excessive may accompany airway inflammation, tissue damage, induce reaction, more serious damage poor prognosis diseases. This review summarizes relationship between related
Language: Английский
Citations
48
Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13
Published: Aug. 25, 2022
Aim The term “Cuproptosis” was coined to describe a novel type of cell death triggered by intracellular copper buildup that is fundamentally distinct from other recognized types such as autophagy, ferroptosis, and pyroptosis in recent days. As the underlying mechanism newly identified, its potential connection pancreatic adenocarcinoma (PAAD) still an open issue. Methods A set machine learning algorithms used develop Cuproptosis-related gene index (CRGI). Its immunological characteristics were studied exploring implications on expression checkpoints, prospective immunotherapy responses, etc. Moreover, sensitivity chemotherapeutic drugs predicted. Unsupervised consensus clustering performed more precisely identify different CRGI-based molecular subtypes investigate chemotherapy efficacy. DLAT, LIPT1 LIAS also investigated, through real-time quantitative polymerase chain reaction (RT-qPCR), western blot, immunofluorescence staining (IFS). Results CRGI identified validated. Additionally, correlation analysis revealed major changes tumor immunology across high- low-CRGI groups. Through in-depth study each medication, it determined predictive efficacy 32 regularly anticancer differed between results subtyping provided support for theories. Expressional assays at transcriptomic proteomic levels suggested aforementioned genes might serve reliable diagnostic biomarkers PAAD. Significance This is, best our knowledge, first examine prognostic prediction PAAD standpoint Cuproptosis. These findings may benefit future therapies.
Language: Английский
Citations
47
Experimental Gerontology, Journal Year: 2023, Volume and Issue: 174, P. 112119 - 112119
Published: Feb. 9, 2023
Low back pain (LBP) is one of the most common health problems in people's lives, which brings a massive burden to clinicians, and leading cause LBP intervertebral disc degeneration (IDD). IDD mainly caused by factors such as aging, mechanical stress, lack nutrition. The pathological mechanism very complex, involving inflammatory response, cell metabolism disorder, so on. Unfortunately, current treatment IDD, only relieving symptoms primary means patient's cannot effectively inhibit or reverse progression IDD. Tumor necrosis factor-α (TNF-α) multifunctional pro-inflammatory factor involved many diseases' processes. With in-depth study more evidence has shown that TNF-α an essential activator related metabolic responses, apoptosis, other processes extracellular dissociation disc. Therefore, anti-TNF-α therapy effective therapeutic target for alleviating especially inhibiting matrix degradation reducing responses. This article reviews role latest research progress inhibitors treating
Language: Английский
Citations
30
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: May 25, 2023
Triple-negative breast cancer (TNBC) is characterized by a high degree of malignancy, early metastasis, limited treatment, and poor prognosis. Immunotherapy, as new most promising treatment for cancer, has efficacy in TNBC because the immunosuppressive tumor microenvironment (TME). Inducing pyroptosis activating cyclic guanosine monophosphate-adenosine monophosphate synthase/interferon gene stimulator (cGAS/STING) signaling pathway to upregulate innate immunity have become an emerging strategy enhancing immunotherapy. In this study, albumin nanospheres were constructed with photosensitizer-IR780 encapsulated core cGAS–STING agonists/H 2 S producer-ZnS loaded on shell (named IR780-ZnS@HSA). vitro , IR780-ZnS@HSA produced photothermal therapy (PTT) photodynamic (PDT) effects. addition, it stimulated immunogenic cell death (ICD) activated cells via caspase-3–GSDME pathway. also The two pathways synergistically boost immune response. vivo + laser significantly inhibited growth 4T1 tumor-bearing mice triggered response, improving anti-APD-L1 antibody (aPD-L1). conclusion, IR780-ZnS@HSA, novel inducer pyroptosis, can inhibit improve aPD-L1.
Language: Английский
Citations
23
Journal of Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 66(18), P. 13072 - 13085
Published: Sept. 13, 2023
To develop next-generation metal drugs with high efficiency and low toxicity for targeting inhibition of gastric tumor growth metastasis, we not only optimized a series ruthenium (Ru, III) 2-hydroxy-1-naphthaldehyde thiosemicarbazone complexes to obtain Ru(III) complex (4b) remarkable cytotoxicity in vitro but also constructed 4b-decitabine (DCT)/liposome (Lip) delivery system (4b-DCT-Lip). The vivo results showed that 4b-DCT-Lip had stronger capacity inhibit metastasis than 4b-DCT addressed the co-delivery problems improved their ability. Furthermore, confirmed mechanism 4b-DCT/4b-DCT-Lip inhibiting tumor. DCT-upregulated gasdermin E (GSDME) was cleaved by 4b-activated caspase-3 afford GSDME-N terminal then aggregated form nonselective pores on cell membrane tumor, thereby inducing pyroptosis pyroptosis-induced immune response.
Language: Английский
Citations
23
MedComm, Journal Year: 2024, Volume and Issue: 5(9)
Published: Sept. 1, 2024
Abstract Cell death regulation is essential for tissue homeostasis and its dysregulation often underlies cancer development. Understanding the different pathways of cell can provide novel therapeutic strategies battling cancer. This review explores several key mechanisms apoptosis, necroptosis, autophagic death, ferroptosis, pyroptosis. The research gap addressed involves a thorough analysis how these be precisely targeted therapy, considering tumor heterogeneity adaptation. It delves into genetic epigenetic factors signaling cascades like phosphatidylinositol 3‐kinase/protein kinase B/mammalian target rapamycin (PI3K/AKT/mTOR) mitogen‐activated protein kinase/extracellular signal‐regulated (MAPK/ERK) pathways, which are critical death. Additionally, interaction microenvironment with cells, particularly influence hypoxia, nutrient deprivation, immune cellular interactions, explored. Emphasizing strategies, this highlights emerging modulators inducers such as B lymphoma 2 (BCL2) homology domain 3 (BH3) mimetics, tumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL), chloroquine, innovative approaches to induce ferroptosis provides insights therapy's future direction, focusing on multifaceted circumvent drug resistance. examination evolving underlines considerable clinical potential continuous necessity in‐depth exploration within scientific domain.
Language: Английский
Citations
14
Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)
Published: Nov. 30, 2024
In the realm of cancer research, tumor microenvironment (TME) plays a crucial role in initiation and progression, shaped by complex interactions between cells surrounding non-cancerous cells. Cytokines, as essential immunomodulatory agents, are secreted various cellular constituents within TME, including immune cells, cancer-associated fibroblasts, themselves. These cytokines facilitate intricate communication networks that significantly influence initiation, metastasis, suppression. Pyroptosis contributes to TME remodeling promoting release pro-inflammatory sustaining chronic inflammation, impacting processes such escape angiogenesis. However, challenges remain due interplay among cytokines, pyroptosis, along with dual effects pyroptosis on progression therapy-related complications like cytokine syndrome. Unraveling these complexities could strategies balance inflammatory responses while minimizing tissue damage during therapy. This review delves into crosstalk elucidating their contribution metastasis. By synthesizing emerging therapeutic targets innovative technologies concerning this aims provide novel insights enhance treatment outcomes for patients.
Language: Английский
Citations
12