Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
15(2), P. 852 - 875
Published: Nov. 23, 2024
Cancer
immunotherapy
is
currently
a
very
promising
therapeutic
strategy
for
treating
tumors.
However,
its
effectiveness
restricted
by
insufficient
antigenicity
and
an
immunosuppressive
tumor
microenvironment
(ITME).
Pyroptosis,
unique
form
of
programmed
cell
death
(PCD),
causes
cells
to
swell
rupture,
releasing
pro-inflammatory
factors
that
can
enhance
immunogenicity
remodel
the
ITME.
Nanomaterials,
with
their
distinct
advantages
different
techniques,
are
increasingly
popular,
nanomaterial-based
delivery
systems
demonstrate
significant
potential
potentiate,
enable,
augment
pyroptosis.
This
review
summarizes
discusses
emerging
field
nanomaterials-induced
pyroptosis,
focusing
on
mechanisms
pyroptosis
pathways
strategies
activate
or
specific
Additionally,
we
provide
perspectives
development
this
field,
aiming
accelerate
further
clinical
transition.
Journal of Hematology & Oncology,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: April 2, 2024
Abstract
Cancer
immunotherapy
and
vaccine
development
have
significantly
improved
the
fight
against
cancers.
Despite
these
advancements,
challenges
remain,
particularly
in
clinical
delivery
of
immunomodulatory
compounds.
The
tumor
microenvironment
(TME),
comprising
macrophages,
fibroblasts,
immune
cells,
plays
a
crucial
role
response
modulation.
Nanoparticles,
engineered
to
reshape
TME,
shown
promising
results
enhancing
by
facilitating
targeted
These
nanoparticles
can
suppress
fibroblast
activation,
promote
M1
macrophage
polarization,
aid
dendritic
cell
maturation,
encourage
T
infiltration.
Biomimetic
further
enhance
increasing
internalization
agents
cells
such
as
cells.
Moreover,
exosomes,
whether
naturally
secreted
body
or
bioengineered,
been
explored
regulate
TME
immune-related
affect
cancer
immunotherapy.
Stimuli-responsive
nanocarriers,
activated
pH,
redox,
light
conditions,
exhibit
potential
accelerate
co-application
with
checkpoint
inhibitors
is
an
emerging
strategy
boost
anti-tumor
immunity.
With
their
ability
induce
long-term
immunity,
nanoarchitectures
are
structures
development.
This
review
underscores
critical
overcoming
current
driving
advancement
modification.
Journal of Translational Medicine,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: March 4, 2025
Although
photothermal
therapy
(PTT)
can
induce
antitumour
immunity,
the
mechanisms
underlying
its
effects
in
pancreatic
cancer
(PC)
require
further
exploration.
In
this
study,
mechanism
of
action
PTT
and
connection
to
pyroptosis
as
well
therapeutic
potential
alone
combination
with
STING
agonists,
were
investigated.
addition,
a
biomarker
PC
was
found
stratify
patients
who
are
suitable
for
PTT.
We
explored
whether
vitro
evaluated
efficacy
immunity-inducing
ability
combined
agonist
(c-di-GMP)
immune
adjuvant
vivo
PC.
also
gasdermin
D
(GSDMD)
expression
tumour
tissues
investigated
drug
sensitivity
patient-derived
organoids
(PDOs)
differential
GSDMD
expression.
Our
study
demonstrated
that
local
induces
via
caspase-1/GSDMD
pathway
elicits
immunity.
exhibits
better
than
while
limiting
distant
metastasis,
enhances
response
by
promoting
dendritic
cell
maturation,
increasing
frequency
infiltrating
T
cells,
converting
macrophages
from
M2
M1
phenotype.
we
is
highly
expressed
overexpression
might
suggest
increased
resistance
chemotherapy
benefits
therapy.
confirmed
PDOs
higher
less
sensitive
chemotherapeutic
agent
(5-Fluorouracil)
lower
expression,
making
new
identifying
may
benefit
work,
c-di-GMP
used
an
treat
first
time,
results
provide
clues
development
novel
immunotherapies
simultaneously
suppress
primary
tumours
metastases.
has
great
selection
individualized
treatment
modalities.
Nanoscale,
Journal Year:
2024,
Volume and Issue:
16(25), P. 11825 - 11848
Published: Jan. 1, 2024
An
overview
of
the
advancements
in
protein
nanoparticles
for
immunotherapy
across
diseases
include
cancer
and
other
like
influenza,
pneumonia,
hepatitis.
