Molecular Therapy — Nucleic Acids,
Journal Year:
2020,
Volume and Issue:
21, P. 792 - 803
Published: July 15, 2020
Emerging
knowledge
indicates
that
non-coding
RNAs,
including
microRNAs
(miRNAs)
and
long-noncoding
RNAs
(lncRNAs),
have
a
pivotal
role
in
bone
development
the
pathogenesis
of
bone-related
disorders.
Most
recently,
miRNAs
started
to
be
regarded
as
potential
biomarkers
or
targets
for
various
sets
diseases,
while
lncRNAs
gained
attention
new
layer
gene
expression
control
acting
through
versatile
interactions,
also
with
miRNAs.
The
rapid
RNA
sequencing
techniques
based
on
next-generation
(NGS)
gives
us
better
insight
into
molecular
pathways
regulated
by
miRNA-lncRNA
network.
In
this
review,
we
summarize
current
related
function
regulators
genes
are
crucial
proper
metabolism
homeostasis.
We
characterized
important
their
signatures,
relationship
bone.
Analysis
biological
lncRNAs,
well
network,
will
pave
way
understanding
think
may
lead
innovative
diagnostic
tools
therapeutic
approaches
International Journal of Molecular Sciences,
Journal Year:
2019,
Volume and Issue:
20(14), P. 3430 - 3430
Published: July 12, 2019
The
normal
bone
regeneration
process
is
a
complex
and
coordinated
series
of
events
involving
different
cell
types
molecules.
However,
this
impaired
in
critical-size/large
defects,
with
non-unions
or
delayed
unions
remaining
major
clinical
problem.
Novel
strategies
are
needed
to
aid
the
current
therapeutic
approaches.
Mesenchymal
stem/stromal
cells
(MSCs)
able
promote
regeneration.
Their
beneficial
effects
can
be
improved
by
modulating
expression
levels
specific
genes
purpose
stimulating
MSC
proliferation,
osteogenic
differentiation
their
immunomodulatory
capacity.
In
context,
genetic
engineering
MSCs
expected
further
enhance
pro-regenerative
properties
accelerate
healing.
Herein,
we
review
most
promising
molecular
candidates
(protein-coding
non-coding
transcripts)
discuss
methodologies
engineer
deliver
MSCs,
mainly
focusing
on
vivo
animal
studies.
Considering
potential
secretome
for
repair,
topic
has
also
been
addressed.
Furthermore,
results
studies
using
discussed.
Finally,
debate
advantages
limitations
genetically-engineered
as
promoters
fracture
regeneration/repair.
Biomedical Reports,
Journal Year:
2020,
Volume and Issue:
13(1), P. 15 - 21
Published: May 15, 2020
Osteogenic
differentiation
originating
from
mesenchymal
stem
cells
(MSCs)
requires
tight
co‑ordination
of
transcriptional
factors,
signaling
pathways
and
biomechanical
cues.
Dysregulation
such
reciprocal
networks
may
influence
the
proliferation
apoptosis
MSCs
osteoblasts,
thereby
impairing
bone
metabolism
homeostasis.
An
increasing
number
studies
have
shown
that
long
non‑coding
(lnc)RNAs
are
involved
in
osteogenic
thus
serve
an
important
role
initiation,
development,
progression
diseases
as
tumors,
osteoarthritis
osteoporosis.
It
has
been
reported
lncRNA,
maternally
expressed
gene
3
(MEG3),
regulates
multiple
also
acts
a
critical
mediator
development
formation
associated
diseases.
In
present
review,
proposed
mechanisms
underlying
roles
MEG3
its
potential
effects
on
discussed.
These
discussions
help
elucidate
highlight
biomarkers
therapeutic
targets
for
treatment
Journal of Applied Microbiology,
Journal Year:
2020,
Volume and Issue:
130(6), P. 2041 - 2062
Published: Sept. 25, 2020
In
this
study,
we
investigated
the
anti‐osteoporotic
effect
of
two
fermented
milk
products
(FMPs)
by
Lactobacillus
plantarum
A41
and
fermentum
SRK414
on
a
rat
model
ovariectomy‐induced
post‐menopausal
primary
osteoporosis.
The
FMPs
increased
bone
volume
mineral
density
(BMD)
in
ovariectomized
(OVX)
rats,
normalized
biomarkers
serum.
Additionally,
they
altered
gene
expression
levels
bone‐metabolism‐related
markers.
Furthermore,
downregulated
bone‐apoptosis‐related
genes
stimulated
ovariectomy.
Interestingly,
decreased
inflammation
markers
serum,
bone,
ileum
colon
rats.
Gut
bacterial
populations
were
also
affected
upon
FMP
treatment
due
to
increase
abundance
genus
Faecalibacterium
prausnitzii.
Milk
L.
can
exhibit
effects
osteoporosis
via
regulating
used
study
be
an
ideal
method
that
has
its
potential
treating
instead
drug
treatments.
Molecular Therapy — Nucleic Acids,
Journal Year:
2020,
Volume and Issue:
21, P. 792 - 803
Published: July 15, 2020
Emerging
knowledge
indicates
that
non-coding
RNAs,
including
microRNAs
(miRNAs)
and
long-noncoding
RNAs
(lncRNAs),
have
a
pivotal
role
in
bone
development
the
pathogenesis
of
bone-related
disorders.
Most
recently,
miRNAs
started
to
be
regarded
as
potential
biomarkers
or
targets
for
various
sets
diseases,
while
lncRNAs
gained
attention
new
layer
gene
expression
control
acting
through
versatile
interactions,
also
with
miRNAs.
The
rapid
RNA
sequencing
techniques
based
on
next-generation
(NGS)
gives
us
better
insight
into
molecular
pathways
regulated
by
miRNA-lncRNA
network.
In
this
review,
we
summarize
current
related
function
regulators
genes
are
crucial
proper
metabolism
homeostasis.
We
characterized
important
their
signatures,
relationship
bone.
Analysis
biological
lncRNAs,
well
network,
will
pave
way
understanding
think
may
lead
innovative
diagnostic
tools
therapeutic
approaches
