Bioelectrochemistry, Journal Year: 2025, Volume and Issue: 164, P. 108917 - 108917
Published: Feb. 3, 2025
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: May 11, 2023
Abstract Angiogenesis, the formation of new blood vessels, is a complex and dynamic process regulated by various pro- anti-angiogenic molecules, which plays crucial role in tumor growth, invasion, metastasis. With advances molecular cellular biology, biomolecules such as growth factors, chemokines, adhesion factors involved angiogenesis has gradually been elucidated. Targeted therapeutic research based on these molecules driven treatment to become promising strategy anti-tumor therapy. The most widely used agents include monoclonal antibodies tyrosine kinase inhibitors (TKIs) targeting vascular endothelial factor (VEGF) pathway. However, clinical benefit this modality still limited due several defects adverse events, acquired drug resistance, recurrence, lack validated biomarkers, impel further mechanisms angiogenesis, development multiple drugs combination therapy figure out how improve efficacy. Here, we broadly summarize signaling pathways discuss current challenges We also propose approaches efficacy provide perspective for
Language: Английский
Citations
543
International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 23(1), P. 146 - 146
Published: Dec. 23, 2021
Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which affect tissue integrity, immune cell recruitment, turnover by degrading extracellular (ECM) components releasing matrikines, surface-bound cytokines, growth factors, or their receptors. Among MMPs, MMP-14 is driving force behind destruction during cancer invasion metastasis. also influences both intercellular as well cell-matrix communication regulating many plasma membrane-anchored proteins. cells other stroma, embedded in a common matrix, interact means various adhesive structures, particularly invadopodia are capable to remodel through spatially temporally finely tuned proteolysis. As deeper understanding underlying functional mechanisms beneficial for development new prognostic predictive markers targeted therapies, this review examined current knowledge interplay MMPs context protein, subcellular, cellular level focus MMP14.
Language: Английский
Citations
290
ACS Applied Bio Materials, Journal Year: 2022, Volume and Issue: 5(9), P. 4028 - 4054
Published: Aug. 31, 2022
Research on the role of reactive oxygen species (ROS) in aging process has advanced significantly over last two decades. In light recent findings, ROS takes part cells along with contributing to various physiological signaling pathways. Antioxidants being cells' natural defense mechanism against ROS-mediated alteration, play an imperative maintain intracellular homeostasis. Although complete understanding regulated is yet be fully comprehended, current insights into sources cellular and their correlation age-related diseases are portrayed this review. addition, results effect antioxidants homeostasis as well advances clinical trials also discussed detail. The future perspective ROS-antioxidant dynamics antiaging research marshaled provide directions for fields.
Language: Английский
Citations
93
Food Bioscience, Journal Year: 2025, Volume and Issue: 64, P. 105853 - 105853
Published: Jan. 6, 2025
Language: Английский
Citations
3
The EPMA Journal, Journal Year: 2021, Volume and Issue: 12(3), P. 243 - 264
Published: Aug. 17, 2021
An increasing interest in a healthy lifestyle raises questions about optimal body weight. Evidently, it should be clearly discriminated between the standardised "normal" weight and individually To this end, basic principle of personalised medicine "one size does not fit all" has to applied. Contextually, but e.g. borderline mass index might for one person apparently suboptimal another strongly depending on individual genetic predisposition, geographic origin, cultural nutritional habits relevant parameters-all included into comprehensive patient profile. Even if only slightly deviant, both overweight underweight are acknowledged risk factors shifted metabolism which, being optimised, may contribute development progression severe pathologies. Development innovative screening programmes is essential promote population health by application risks assessment, individualised profiling multi-parametric analysis, further used cost-effective targeted prevention treatments tailored person. The following healthcare areas considered potentially benefiting from above proposed measures: conditions, sports medicine, stress overload associated complications, planned pregnancies, periodontal dentistry, sleep eye disorders, inflammatory healing pain management, metabolic cardiovascular disease, cancers, psychiatric neurologic stroke known unknown aetiology, improved outcomes under pandemic conditions such as COVID-19. In long-term way, significantly economy benefits paradigm shift reactive Predictive, Preventive Personalised Medicine (PPPM/3PM). A tight collaboration all stakeholders including scientific community, givers, organisations, policy-makers educators smooth implementation 3PM concepts daily practice.
Language: Английский
Citations
104
Cellular and Molecular Immunology, Journal Year: 2021, Volume and Issue: 19(1), P. 33 - 45
Published: Aug. 20, 2021
Abstract Decades of advancements in immuno-oncology have enabled the development current immunotherapies, which provide long-term treatment responses certain metastatic cancer patients. However, cures remain infrequent, and most patients ultimately succumb to treatment-refractory disease. Recent insights suggest that tumors at organ sites exhibit distinctive response patterns immunotherapy can even reduce antitumor immunity within anatomically distant tumors, suggesting activation tissue-specific immune tolerogenic mechanisms some cases therapy resistance. Specialized cells known as regulatory T (Tregs) are present all tissues body coordinate suppression excessive curb autoimmunity maintain homeostasis. Despite high volume research on Tregs, findings failed reconcile Treg functions organs, such tolerance, tissue repair, regeneration, with their local systemic tumor context To improve understanding how Tregs impact immunotherapy, we review specialized role clinically common challenging metastasis, highlight describes impacts regulation summarize ongoing work reporting feasible strategies combine specific targeting immunotherapy. Improved knowledge framework biology clinical metastasis will enable more precise profound implications for treating cancer.
Language: Английский
Citations
89
Nature reviews. Cancer, Journal Year: 2022, Volume and Issue: 22(10), P. 593 - 602
Published: Aug. 23, 2022
Language: Английский
Citations
55
Molecular Cancer, Journal Year: 2022, Volume and Issue: 21(1)
Published: May 10, 2022
Abstract Brain metastasis (BrM) is a major problem associated with cancer-related mortality, and currently, no specific biomarkers are available in clinical settings for early detection. Liquid biopsy widely accepted as non-invasive method diagnosing cancer other diseases. We have reviewed the evidence that shows how molecular alterations involved BrM, majorly from breast (BC), lung (LC), melanoma, an inception they can be employed biomarker development. discussed genetic epigenetic changes influence cells to breach blood-brain barrier (BBB) help establish metastatic lesions uniquely distinct brain microenvironment. Keeping abreast recent breakthroughs context of various biomolecules detections identifications, circulating tumor (CTC), cell-free nucleotides, non-coding RNAs, secretory proteins, metabolites pursued human body fluids such blood, serum, cerebrospinal fluid (CSF), urine obtain potential candidates The liquid biopsy-based overlay current imaging techniques amplify signal viable improving detection treatments occult BrM.
Language: Английский
Citations
45
The EPMA Journal, Journal Year: 2022, Volume and Issue: 13(4), P. 535 - 545
Published: Nov. 17, 2022
Due to the reactive medical approach applied disease management, stroke has reached an epidemic scale worldwide. In 2019, global prevalence was 101.5 million people, wherefrom 77.2 (about 76%) suffered from ischemic stroke; 20.7 and 8.4 intracerebral subarachnoid haemorrhage, respectively. Globally in year 2019 - 3.3, 2.9 0.4 individuals died of stroke, During last three decades, absolute number cases increased substantially. The current is 110 patients worldwide with more than 60% below age 70 years. Prognoses by World Stroke Organisation are pessimistic: globally, it predicted that 1 4 adults over 25 will suffer their lifetime. Although best known contributing factor, 16% all strokes occur teenagers young aged 15-49 years incidence trend this population increasing. corresponding socio-economic burden which leading cause disability, enormous. Global costs estimated at 721 billion US dollars, 0.66% GDP. Clinically manifested only "tip iceberg": total about 14 times greater currently capable identify manage. Specifically, lacunar (LS), characteristic for silent brain infarction, represents up 30% strokes. Silent LS, diagnosed mainly routine health check-up autopsy without history, a reported infarction 55% investigated populations. To end, independent predictor stroke. Further, small vessel considered strong contributors cognitive impairments, dementia, depression suicide, amongst others general population. sub-populations such as diabetes mellitus type 2, proliferative diabetic retinopathy According various statistical sources, cryptogenic account 15 40% entire incidence. question consider here is, whether fully referable unidentifiable aetiology or rather underestimated risks. Considering latter, translational research might be great clinical utility realise innovative predictive preventive approaches, potentially benefiting high risk society large. position paper, consortium combined multi-professional expertise provide clear statements towards paradigm change predictive, personalised medicine crucial elements are:Consolidation multi-disciplinary including family medicine, in-depth diagnostics followed targeted primary secondary (e.g. treated cancer) prevention infarctionApplication assessment focused on sub-optimal conditions effectively prevent health-to-disease transitionApplication AI machine learning treatment algorithms tailored robust biomarker patternsApplication screening programmes adequately needs
Language: Английский
Citations
43
Frontiers in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 10
Published: Aug. 17, 2022
Metastasis, a primary cause of death in patients with malignancies, is promoted by intrinsic changes both tumor and non-malignant cells the microenvironment (TME). As major components TME, tumor-associated neutrophils (TANs) promote progression metastasis through communication multiple growth factors, chemokines, inflammatory other immune cells, which together establish an immunosuppressive TME. In this review, we describe potential mechanisms TANs participate based on recent experimental evidence. We have focused drugs chemotherapeutic regimens that target TANs, thereby providing promising future for cancer immunotherapy.
Language: Английский
Citations
39