Synthetic extracellular matrices with function-encoding peptides

Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 1(7), P. 518 - 536

Published: April 25, 2023

Language: Английский

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The immunomodulatory role of matrix metalloproteinases in colitis-associated cancer

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 19, 2023

Matrix metalloproteinases (MMPs) are an important class of enzymes in the body that function through extracellular matrix (ECM). They involved diverse pathophysiological processes, such as tumor invasion and metastasis, cardiovascular diseases, arthritis, periodontal disease, osteogenesis imperfecta, diseases central nervous system. MMPs participate occurrence development numerous cancers closely related to immunity. In present study, we review immunomodulatory role colitis-associated cancer (CAC) discuss relevant clinical applications. We analyze more than 300 pharmacological studies retrieved from PubMed Web Science, MMPs, cancer, colitis, CAC, immunomodulation. Key interfere with pathological processes CAC MMP-2, MMP-3, MMP-7, MMP-9, MMP-10, MMP-12, MMP-13, well their corresponding mechanisms elaborated. cell proliferation, differentiation, angiogenesis, ECM remodeling, inflammatory response CAC. also affect immune system by modulating differentiation activity cells, recruitment macrophages, neutrophils. Herein describe facilitate treatment this special type colon which is preceded detectable bowel disease populations.

Language: Английский

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Targeting the tumor microenvironment: Potential strategy for cancer therapeutics

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2023, Volume and Issue: 1869(6), P. 166746 - 166746

Published: May 7, 2023

Cellular and stromal components including tumor cells, immune mesenchymal cancer-linked fibroblasts, extracellular matrix, constituent microenvironment (TME). TME plays a crucial role in reprogramming initiation, uncontrolled proliferation, invasion metastasis as well response to therapeutic modalities. In recent years targeting the has developed potential strategy for treatment of cancer because its life-threatening functions restricting development modulating responses standard-of-care medicines. Cold atmospheric plasma, oncolytic viral therapy, bacterial nano-vaccine, repurposed pharmaceuticals with combination antiangiogenic drugs, immunotherapies are among most effective therapies directed by that have either been clinically authorized or currently being studied. This article discusses above-mentioned light TME. We also cover problems related TME-targeted therapies, future insights practical uses this rapidly growing field.

Language: Английский

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Mechanism insights and therapeutic intervention of tumor metastasis: latest developments and perspectives

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 2, 2024

Abstract Metastasis remains a pivotal characteristic of cancer and is the primary contributor to cancer-associated mortality. Despite its significance, mechanisms governing metastasis are not fully elucidated. Contemporary findings in domain biology have shed light on molecular aspects this intricate process. Tumor cells undergoing invasion engage with other cellular entities proteins en route their destination. Insights into these engagements enhanced our comprehension principles directing movement adaptability metastatic cells. The tumor microenvironment plays role facilitating proliferation by enabling navigate through stromal barriers. Such attributes influenced genetic epigenetic changes occurring surrounding milieu. A profound understanding process’s biological indispensable for devising efficacious therapeutic strategies. This review delves recent developments concerning metastasis-associated genes, important signaling pathways, microenvironment, metabolic processes, peripheral immunity, mechanical forces metastasis. In addition, we combine advances particular emphasis prospect developing effective interventions including most popular immunotherapies nanotechnology combat We also identified limitations current research metastasis, encompassing drug resistance, restricted animal models, inadequate biomarkers early detection methods, as well heterogeneity among others. It anticipated that comprehensive will significantly contribute advancement research.

Language: Английский

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Circulating tumor cells: from new biological insights to clinical practice

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Sept. 2, 2024

Abstract The primary reason for high mortality rates among cancer patients is metastasis, where tumor cells migrate through the bloodstream from original site to other parts of body. Recent advancements in technology have significantly enhanced our comprehension mechanisms behind bloodborne spread circulating (CTCs). One critical process, DNA methylation, regulates gene expression and chromosome stability, thus maintaining dynamic equilibrium Global hypomethylation locus-specific hypermethylation are examples changes methylation patterns that pivotal carcinogenesis. This comprehensive review first provides an overview various processes contribute formation CTCs, including epithelial-mesenchymal transition (EMT), immune surveillance, colonization. We then conduct in-depth analysis how modifications within CTCs impact each these stages during CTC dissemination. Furthermore, we explored potential clinical implications with cancer. By understanding epigenetic modifications, can gain insights into metastatic process identify new biomarkers early detection, prognosis, targeted therapies. aims bridge gap between basic research application, highlighting significance context metastasis offering avenues improving patient outcomes.

Language: Английский

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The role and regulation of integrins in cell migration and invasion

Nature Reviews Molecular Cell Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 30, 2024

Language: Английский

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Plasticity of cancer invasion and energy metabolism

Trends in Cell Biology, Journal Year: 2022, Volume and Issue: 33(5), P. 388 - 402

Published: Oct. 31, 2022

Energy deprivation is a frequent adverse event in tumors that caused by mutations, malperfusion, hypoxia, and nutrition deficit. The resulting bioenergetic stress leads to signaling metabolic adaptation responses tumor cells, secures survival, adjusts migration activity. kinetic of cancer cells energy deficit were recently identified, including switch invasive energy-conservative amoeboid an enhanced capability for distant metastasis. We review the programs employed different invasion modes collective, mesenchymal, migration, as well their interconversion response deprivation, we discuss consequences metastatic escape. Understanding requirements other dissemination strategies offers rationales improving therapeutic targeting progression.

Language: Английский

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Targeting matrix metalloproteinases by E3 ubiquitin ligases as a way to regulate the tumor microenvironment for cancer therapy

Seminars in Cancer Biology, Journal Year: 2022, Volume and Issue: 86, P. 259 - 268

Published: June 18, 2022

Language: Английский

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Polysaccharide‐Based Stimulus‐Responsive Nanomedicines for Combination Cancer Immunotherapy

Small, Journal Year: 2023, Volume and Issue: 19(23)

Published: March 8, 2023

Cancer immunotherapy is a promising antitumor approach, whereas nontherapeutic side effects, tumor microenvironment (TME) intricacy, and low immunogenicity limit its therapeutic efficacy. In recent years, combination with other therapies has been proven to considerably increase However, achieving codelivery of the drugs site remains major challenge. Stimulus-responsive nanodelivery systems show controlled drug delivery precise release. Polysaccharides, family potential biomaterials, are widely used in development stimulus-responsive nanomedicines due their unique physicochemical properties, biocompatibility, modifiability. Here, activity polysaccharides several combined strategies (e.g., chemotherapy, photodynamic therapy, or photothermal therapy) summarized. More importantly, progress polysaccharide-based for cancer discussed, focus on construction nanomedicine, targeted delivery, release, enhanced effects. Finally, limitations application prospects this new field discussed.

Language: Английский

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Baicalin and baicalein in modulating tumor microenvironment for cancer treatment: A comprehensive review with future perspectives

Pharmacological Research, Journal Year: 2023, Volume and Issue: 199, P. 107032 - 107032

Published: Dec. 5, 2023

Cancer is a leading cause of death worldwide. The burden cancer incidence and mortality increasing rapidly. New approaches to prevention treatment are urgently needed. Natural products reliable powerful sources for anticancer drug discovery. Baicalin baicalein, two major flavones isolated from Scutellaria baicalensis Georgi, multi-purpose traditional medicinal plant in China, exhibit activities against multiple cancers. Of note, these phytochemicals extremely low toxicity normal cells. Besides their cytotoxic cytostatic toward diverse tumor cells, recent studies demonstrated that baicalin baicalein modulate variety stromal cells extracellular matrix (ECM) the microenvironment (TME), which essential tumorigenesis, progression metastasis. In this review, we summarize therapeutic potential mechanism action regulation microenvironmental immune endothelial fibroblasts, ECM reshape TME signaling, inhibition angiogenesis, progression, addition, discuss biotransformation pathways related challenges future research directions improve bioavailability clinical applications. Recent advances warrant continued study as important natural ways interception therapy.

Language: Английский

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