The evolving process of ferroptosis in thyroid cancer: Novel mechanisms and opportunities DOI Creative Commons

Lin Yin,

Xiaodan Luo, Xian Zhang

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(16)

Published: Aug. 1, 2024

Thyroid cancer (TC) is a prevalent endocrine malignancy, with significant increase in incidence worldwide. Ferroptosis novel form of programmed cell death, primarily caused by iron overload and reactive oxygen species (ROS)-dependent accumulation lipid peroxides. The main manifestations cellular ferroptosis are rupture the outer membrane, crumpling mitochondria shrinkage or disappearance mitochondrial cristae, thus leading to death. an important phenomenon tumour progression, crosstalk tumour-associated signalling pathways profoundly affecting immune effects treatment outcomes. functions mechanisms TC have also attracted increasing attention, mainly terms influencing proliferation, invasion, migration, response, therapeutic susceptibility genetic susceptibility. However, at present, biology morphological, biological mechanism much less deep than other malignancies. Hence, this review, we highlighted emerging role including potential opportunities for diagnosis treatment, as well discussed limitations prospects. Ferroptosis-based diagnostic strategies can potentially provide complementary management TCs.

Language: Английский

The role of RNA methylation in tumor immunity and its potential in immunotherapy DOI Creative Commons
Yan Li,

Haoer Jin,

Qingling Li

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: June 20, 2024

Abstract RNA methylation, a prevalent post-transcriptional modification, has garnered considerable attention in research circles. It exerts regulatory control over diverse biological functions by modulating splicing, translation, transport, and stability. Notably, studies have illuminated the substantial impact of methylation on tumor immunity. The primary types encompass N6-methyladenosine (m6A), 5-methylcytosine (m5C), N1-methyladenosine (m1A), N7-methylguanosine (m7G), 3-methylcytidine (m3C). Compelling evidence underscores involvement regulating microenvironment (TME). By affecting translation stability through "writers", "erasers" "readers", influence dysregulation immune cells factors. Consequently, plays pivotal role immunity mediating various behaviors, encompassing proliferation, invasion, metastasis, etc. In this review, we discussed mechanisms several methylations, providing comprehensive overview their roles underlying within among immunocytes. exploring how these modifications mediate evasion, also examine potential applications immunotherapy. This review aims to provide novel insights strategies for identifying targets advancing cancer immunotherapy efficacy.

Language: Английский

Citations

30
New insights into the role of macrophages in cancer immunotherapy DOI Creative Commons
Zhou Li, Tiantian Zhao,

Ruzhe Zhang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 28, 2024

Macrophages are the main component of tumor microenvironment, which differentiated from monocytes in blood and play an important role cancer development. Tumor-associated macrophages (TAMs) can promote growth, invasion, metastasis, resistance to anti–programmed death receptor 1 therapy by regulating programmed cell ligand expression interacting with other immune cells microenvironment. However, when activated properly, also anti-tumor enhancing phagocytosis cytotoxicity cells. TAM is associated poor prognosis drug patients treated immunotherapy, indicating that attractive targets for combined treatment. Combination targeting TAMs immunotherapy overcomes achieved excellent results some cancers, may be a promising strategy treatment future. Herein, we review recent findings on development, immunotherapy. We focus mainly macrophage-centered therapy, including strategies deplete reprogram TAMs, represent potential improving efficacy.

Language: Английский

Citations

19
Targeting the PD-1/PD-L1 Signaling Pathway for Cancer Therapy: Focus on Biomarkers DOI Open Access
Αreti Strati, Christos Adamopoulos, Ioannis Kotsantis

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1235 - 1235

Published: Jan. 31, 2025

The PD1/PD-L1 axis plays an important immunosuppressive role during the T-cell-mediated immune response, which is essential for physiological homeostasis of system. biology immunological microenvironment extremely complex and crucial development treatment strategies immunotherapy. Characterization immunological, genomic or transcriptomic landscape cancer patients could allow discrimination between responders non-responders to anti-PD-1/PD-L1 therapy. Immune checkpoint inhibitor (ICI) therapy has shown remarkable efficacy in a variety malignancies landmark trials fundamentally changed Current research focuses on maximize patient selection therapy, clarify mechanisms resistance, improve existing biomarkers, including PD-L1 expression tumor mutational burden (TMB), discover new biomarkers. In this review, we focus function PD-1/PD-L1 signaling pathway discuss genomic, epigenetic receiving Finally, provide overview clinical testing antibodies against PD-1/PD-L1.

Language: Английский

Citations

2
LncRNA-encoded peptides in cancer DOI Creative Commons

Yaguang Zhang

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: Aug. 12, 2024

Long non-coding RNAs (lncRNAs), once considered transcriptional noise, have emerged as critical regulators of gene expression and key players in cancer biology. Recent breakthroughs revealed that certain lncRNAs can encode small open reading frame (sORF)-derived peptides, which are now understood to contribute the pathogenesis various cancers. This review synthesizes current knowledge on detection, functional roles, clinical implications lncRNA-encoded peptides cancer. We discuss technological advancements detection validation sORFs, including ribosome profiling mass spectrometry, facilitated discovery these peptides. The roles processes such transcription, translation regulation, signal transduction, metabolic reprogramming explored types potential is highlighted, with a focus their utility diagnostic biomarkers, prognostic indicators, therapeutic targets. challenges future directions translating findings into practice also discussed, need for large-scale validation, development sensitive methods, optimization peptide stability delivery.

Language: Английский

Citations

15
RNA modifications in cancer DOI Creative Commons

Han Wu,

Shi Chen, Xiang Li

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(1)

Published: Jan. 1, 2025

Abstract RNA modifications are emerging as critical cancer regulators that influence tumorigenesis and progression. Key modifications, such N6‐methyladenosine (m 6 A) 5‐methylcytosine 5 C), implicated in various cellular processes. These regulated by proteins write, erase, read modulate stability, splicing, translation, degradation. Recent studies have highlighted their roles metabolic reprogramming, signaling pathways, cell cycle control, which essential for tumor proliferation survival. Despite these scientific advances, the precise mechanisms affect remain inadequately understood. This review comprehensively examines role play proliferation, metastasis, programmed death, including apoptosis, autophagy, ferroptosis. It explores effects on epithelial–mesenchymal transition (EMT) immune microenvironment, particularly metastasis. Furthermore, modifications’ potential therapies, conventional treatments, immunotherapy, targeted is discussed. By addressing aspects, this aims to bridge current research gaps underscore therapeutic of targeting improve treatment strategies patient outcomes.

Language: Английский

Citations

1
Exosome crosstalk between cancer stem cells and tumor microenvironment: cancer progression and therapeutic strategies DOI Creative Commons
Qi Li, Guangpeng He, Yifan Yu

et al.

Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 22, 2024

Abstract Cancer stem cells (CSCs) represent a small yet pivotal subset of tumor endowed with self-renewal capabilities. These are intricately linked to progression and central drug resistance, metastasis, recurrence. The microenvironment (TME) encompasses the cancer their surrounding milieu, including immune inflammatory cells, cancer-associated fibroblasts, adjacent stromal tissues, vasculature, variety cytokines chemokines. Within TME, such as endothelial adipocytes, fibroblasts release growth factors, cytokines, chemokines, exosomes, which can either sustain or disrupt CSCs, thereby influencing progression. Conversely, CSCs also secrete affecting various components TME. Exosomes, extracellular vesicles (EVs), carry complex cargo nucleic acids, proteins, lipids, playing crucial role in communication between This review primarily focuses on impact exosomes secreted by (CSC-exo) progression, roles maintaining stemness, promoting angiogenesis, facilitating inducing suppression, contributing resistance. Additionally, we discuss how different within TME affect CSCs. Finally, explore potential utilizing mitigate detrimental effects target eliminate them. A thorough understanding exosome-mediated crosstalk could provide valuable insights for developing targeted therapies against

Language: Английский

Citations

8
Extracellular vesicles as modifiers of epigenomic profiles DOI
Haifeng Zhou, Sheng Hu, Wei Yan

et al.

Trends in Genetics, Journal Year: 2024, Volume and Issue: 40(9), P. 797 - 809

Published: June 5, 2024

Language: Английский

Citations

7
SETMAR Facilitates the Differentiation of Thyroid Cancer by Regulating SMARCA2‐Mediated Chromatin Remodeling DOI Creative Commons
Wei Zhang, Xianhui Ruan, Yue Huang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(32)

Published: June 20, 2024

Abstract Thyroid cancer is the most common type of endocrine cancer, and patients have a good prognosis. However, thyroid differentiation status strongly affects patient response to conventional treatment Therefore, exploring molecular mechanisms that influence very important for understanding progression this disease improving therapeutic options. In study, SETMAR as key gene identified. significantly regulates proliferation, epithelial‐mesenchymal transformation (EMT), differentiation‐related expression, radioactive iodine uptake, sensitivity MAPK inhibitor‐based redifferentiation therapies cells. Mechanistically, methylates dimethylated H3K36 in SMARCA2 promoter region promote transcription. can bind enhancers transcription factors (TTFs) PAX8, FOXE1 their expression by enhancing chromatin accessibility. Moreover, METTL3‐mediated m6A methylation SETAMR mRNA observed showed medication affect an IGF2BP3‐dependent manner. Finally, METTL3‐14‐WTAP activator effectively facilitates cells via SETMAR‐SMARCA2‐TTF axis utilized. The research provides novel insights into underlying dedifferentiation new approach therapeutically promoting redifferentiation.

Language: Английский

Citations

7
Macrophage-coated tumor cluster aggravates hepatoma invasion and immunotherapy resistance via generating local immune deprivation DOI Creative Commons
Junya Ning, Yingnan Ye,

Hongru Shen

et al.

Cell Reports Medicine, Journal Year: 2024, Volume and Issue: 5(5), P. 101505 - 101505

Published: April 12, 2024

Immune checkpoint inhibitors (ICIs) represent a promising treatment for hepatocellular carcinoma (HCC) due to their capacity abundant lymphocyte infiltration. However, some patients with HCC respond poorly ICI therapy the presence of various immunosuppressive factors in tumor microenvironment. Our research reveals that macrophage-coated cluster (MCTC) signifies unique spatial structural organization correlating diminished recurrence-free survival and overall total 572 cases from 3 internal cohorts 2 independent external validation cohorts. Mechanistically, tumor-derived macrophage-associated lectin Mac-2 binding protein (M2BP) induces MCTC formation traps immunocompetent cells at edge MCTCs induce intratumoral cytotoxic T cell exclusion local immune deprivation. Blocking M2BP antagonist might provide an effective approach prevent formation, enhance infiltration, thereby improve efficacy HCC.

Language: Английский

Citations

6
Kushenol O Regulates GALNT7/NF-κB axis-Mediated M2 Macrophage Polarization and Efferocytosis in Papillary Thyroid Carcinoma DOI
Yutong Li,

Jianhang Miao,

Chizhuai Liu

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 138, P. 156373 - 156373

Published: Jan. 14, 2025

Language: Английский

Citations

0