Non-coding RNAs modulate function of extracellular matrix proteins DOI Open Access
Nader Akbari Dilmaghani, Hamed Shoorei, Guive Sharifi

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 136, P. 111240 - 111240

Published: Jan. 19, 2021

The extracellular matrix (ECM) creates a multifaceted system for the interaction of diverse structural proteins, matricellular molecules, proteoglycans, hyaluronan, and various glycoproteins that collaborate bind with each other to produce bioactive polymer. Alterations in composition configuration ECM elements influence cellular phenotype, thus participating pathogenesis several human disorders. Recent studies indicate crucial roles non-coding RNAs modulation ECM. Several miRNAs such as miR-21, miR-26, miR-19, miR-140, miR-29, miR-30, miR-133 have been dysregulated disorders are associated disruption or breakdown Moreover, expression MALAT1, PVT1, SRA1, n379519, RMRP, PFL, TUG1, TM1P3, FAS-AS1, PART1, XIST, lncRNAs is altered modification components. In current review, we discuss role their relevance pathophysiology cardiac/ lung fibrosis, cardiomyopathy, heart failure, asthma, osteoarthritis, cancers.

Language: Английский

Gasdermin D in pyroptosis DOI Creative Commons
Brandon E. Burdette, Ashley N. Esparza, Hua Zhu

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2021, Volume and Issue: 11(9), P. 2768 - 2782

Published: April 28, 2021

Pyroptosis is the process of inflammatory cell death. The primary function pyroptosis to induce strong responses that defend host against microbe infection. Excessive pyroptosis, however, leads several diseases, including sepsis and autoimmune disorders. can be canonical or noncanonical. Upon infection, pathway responds pathogen-associated molecular patterns (PAMPs) damage-associated (DAMPs), while noncanonical intracellular lipopolysaccharides (LPS) Gram-negative bacteria. last step requires cleavage gasdermin D (GsdmD) at D275 (numbering after human GSDMD) into N- C-termini by caspase 1 in 4/5/11 (caspase 4/5 humans, 11 mice) pathway. cleavage, N-terminus GsdmD (GsdmD-N) forms a transmembrane pore releases cytokines such as IL-1β IL-18 disturbs regulation ions water, eventually resulting inflammation Since effector promising inhibitors have been developed for diseases. This review will focus on roles during

Language: Английский

Citations

449
The interplay of ROS and the PI3K/Akt pathway in autophagy regulation DOI

Lakhan Kma,

Taranga Jyoti Baruah

Biotechnology and Applied Biochemistry, Journal Year: 2021, Volume and Issue: 69(1), P. 248 - 264

Published: Jan. 15, 2021

Autophagy causes the breakdown of damaged proteins and organelles to their constituent components. The phosphatidylinositol 3-kinase (PI3K) pathway played an important role in regulating autophagic response cells changing reactive oxygen species (ROS) levels. PI3K α catalytic subunit inhibits autophagy, while its β promotes autophagy changes ROS downstream Akt protein acts against initiation increases levels under nutrient-rich conditions. by activating a mechanistic target rapamycin complex 1 (mTORC1) arresting gene expression. AMP-activated kinase (AMPK) counteracts actions. mTORC1 mTORC2 inhibit moderate levels, but high can promote cellular senescence via autophagy. Phosphatase tensin homolog (PTEN) are negative regulators pathway, it has proautophagic activities. Studies conducted on treated with flavonoids ionizing radiation showed that increase flavonoid-treated groups corresponded higher PTEN lowered leading occurrence In contrast, evoked caused lowering incidence

Language: Английский

Citations

246
Biological drug and drug delivery-mediated immunotherapy DOI Creative Commons
Qingqing Xiao, Xiaotong Li, Yi Li

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2020, Volume and Issue: 11(4), P. 941 - 960

Published: Dec. 31, 2020

The initiation and development of major inflammatory diseases, i.e., cancer, vascular inflammation, some autoimmune diseases are closely linked to the immune system. Biologics-based immunotherapy is exerting a critical role against these whereas usage immunomodulators always limited by various factors such as susceptibility digestion enzymes in vivo, poor penetration across biological barriers, rapid clearance reticuloendothelial Drug delivery strategies potent promote their delivery. Herein, we reviewed potential targets for discussed biologics drug systems involved immunotherapy, particularly highlighted approved therapy tactics, finally offer perspectives this field.

Language: Английский

Citations

156
Glioma: molecular signature and crossroads with tumor microenvironment DOI Creative Commons
Lennart Barthel, Martin Hadamitzky, Philipp Dammann

et al.

Cancer and Metastasis Reviews, Journal Year: 2021, Volume and Issue: 41(1), P. 53 - 75

Published: Oct. 23, 2021

Abstract In patients with glioblastoma, the average survival time current treatments is short, mainly due to recurrences and resistance therapy. This insufficient treatment success is, in large parts, tremendous molecular heterogeneity of gliomas, which affects overall prognosis response therapies plays a vital role gliomas’ grading. addition, tumor microenvironment major player for glioma development Active communication between cells local or neighboring healthy immune environment promotes cancerogenic processes contributes establishing stem cells, drives therapy resistance. Besides genetic alterations primary tumor, tumor-released factors, cytokines, proteins, extracellular vesicles, environmental influences like hypoxia provide ability evade host surveillance machinery promote disease progression. Moreover, there increasing evidence that these players affect biological properties gliomas enable inter-cell supports pro-cancerogenic cell properties. Identifying characterizing complex mechanisms are inevitably necessary adapt therapeutic strategies develop novel measures. Here we an update about junctions where constant traffic biomolecules adds complexity management glioblastoma. Graphical abstract

Language: Английский

Citations

137
Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns DOI Creative Commons
Harshani Nadeeshani, Jinyao Li, Tianlei Ying

et al.

Journal of Advanced Research, Journal Year: 2021, Volume and Issue: 37, P. 267 - 278

Published: Aug. 11, 2021

Elderly population has been progressively rising in the world, thus demand for anti-aging heath products to assure longevity as well ameliorate age-related complications is also on rise. Among various health products, nicotinamide mononucleotide (NMN) gaining attentions of consumers and scientific community.This article intends provide an overview current knowledge promises safety concerns NMN product.Nicotinamide adenine dinucleotide (NAD+) levels body deplete with aging it associated downregulation energy production mitochondria, oxidative stress, DNA damage, cognitive impairment inflammatory conditions. However, NMN, precursor NAD+, can slow down this process by elevating NAD+ body. A number vivo studies have indicated affirmative results therapeutic effects age-induced supplementation. One preclinical one clinical study conducted investigate administration while a few more human trials are being conducted. As there large influx based market, proper investigations urgently needed find out effectiveness

Language: Английский

Citations

134
Role of miRNA and lncRNAs in organ fibrosis and aging DOI Open Access
Soudeh Ghafouri‐Fard, Atefe Abak,

Seyedeh Fahimeh Talebi

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 143, P. 112132 - 112132

Published: Sept. 1, 2021

Fibrosis is the endpoint of pathological remodeling. This process contributes to pathogenesis several chronic disorders and aging-associated organ damage. Different molecular cascades contribute this process. TGF-β, WNT, YAP/TAZ signaling pathways have prominent roles in A number long non-coding RNAs microRNAs been found regulate fibrosis through modulation activity related pathways. miR-144-3p, miR-451, miR-200b, miR-328 are among that participate pathology cardiac fibrosis. Meanwhile, miR-34a, miR-17-5p, miR-122, miR-146a, miR-350 liver different situations. PVT1, MALAT1, GAS5, NRON, PFL, MIAT, HULC, ANRIL, H19 We review impact aging-related pathologies.

Language: Английский

Citations

118
Colorectal cancer: the facts in the case of the microbiota DOI Creative Commons
Slater L. Clay, Diogo Fonseca‐Pereira, Wendy S. Garrett

et al.

Journal of Clinical Investigation, Journal Year: 2022, Volume and Issue: 132(4)

Published: Feb. 14, 2022

The importance of the microbiota in development colorectal cancer (CRC) is increasingly evident, but identifying specific microbial features that influence CRC initiation and progression remains a central task for investigators. Studies determining mechanisms directly contribute to or are revealing bacterial factors such as toxins carcinogenesis. However, even when investigators have identified bacteria express toxins, questions remain about host determinants toxin's cancer-potentiating effects. For other cancer-correlating lack challenge define cancer-relevant virulence factors. Herein, we evaluate three CRC-correlating bacteria, colibactin-producing Escherichia coli, enterotoxigenic Bacteroides fragilis, Fusobacterium nucleatum, their relevant CRC. We also consider beneficial bioactivity gut microbes by highlighting metabolite may enhance antitumor immunity. In doing so, aim elucidate unique shared underlying microbiota's contributions accelerate investigation from target validation therapeutic discovery.

Language: Английский

Citations

112
A Review of Gut Microbiota‐Derived Metabolites in Tumor Progression and Cancer Therapy DOI Creative Commons
Qiqing Yang, Bin Wang, Qinghui Zheng

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(15)

Published: March 23, 2023

Abstract Gut microbiota‐derived metabolites are key hubs connecting the gut microbiome and cancer progression, primarily by remodeling tumor microenvironment regulating signaling pathways in cells multiple immune cells. The use of microbial radiotherapy chemotherapy mitigates severe side effects from treatment improves efficacy treatment. Immunotherapy combined with effectively activates system to kill tumors overcomes drug resistance. Consequently, various novel strategies have been developed modulate metabolites. Manipulation genes involved metabolism using synthetic biology approaches directly affects levels metabolites, while fecal transplantation phage affect altering composition microbiome. However, some harbor paradoxical functions depending on context (e.g., type cancer). Furthermore, metabolic microorganisms certain anticancer drugs such as irinotecan gemcitabine, render ineffective or exacerbate their adverse effects. Therefore, a personalized comprehensive consideration patient's condition is required when employing treat cancer. purpose this review summarize correlation between cancer, provide fresh ideas for future scientific research.

Language: Английский

Citations

100
The microbial landscape of colorectal cancer DOI
Maxwell T. White, Cynthia L. Sears

Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 22(4), P. 240 - 254

Published: Oct. 4, 2023

Language: Английский

Citations

55
Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson's disease DOI Creative Commons
Kai Zhang, Shiou Zhu, Jiamei Li

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2021, Volume and Issue: 11(10), P. 3015 - 3034

Published: Feb. 26, 2021

Parkinson's disease (PD), known as one of the most universal neurodegenerative diseases, is a serious threat to health elderly. The current treatment has been demonstrated relieve symptoms, and discovery new small-molecule compounds regarded promising strategy. Of note, homeostasis autolysosome pathway (ALP) closely associated with PD, impaired autophagy may cause death neurons thereby accelerating progress PD. Thus, pharmacological targeting drawn rising attention so far. In this review, we focus on summarizing several autophagy-associated targets, such AMPK, mTORC1, ULK1, IMPase, LRRK2, beclin-1, TFEB, GCase, ERRα, C-Abelson, well their relevant in PD models, which will shed light clue exploiting more potential targeted drugs tracking near future.

Language: Английский

Citations

93