Trends in Cell Biology, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Redox Biology, Journal Year: 2024, Volume and Issue: 71, P. 103092 - 103092
Published: Feb. 16, 2024
In this review, we explore how short-chain fatty acids (SCFAs) produced by the gut microbiome affect Parkinson's disease (PD) through their modulatory interactions with alpha-synuclein, neuroinflammation, and oxidative stress mediated reactive oxygen nitrogen species (ROS/RNS). particular, SCFAs-such as acetate, propionate, butyrate-are involved in gut-brain communication can modulate alpha-synuclein aggregation, a hallmark of PD. The patients PD has lower levels SCFAs than healthy individuals. Probiotics may be potential strategy to restore alleviate symptoms, but underlying mechanisms are not fully understood. Also discuss present guts brains PD, induce neuroinflammation via ROS/RNS. Alpha-synuclein is considered an early biomarker for link axis pathogenesis. Therefore, elucidating role impact on alpha-synuclein-induced microglia ROS/RNS crucial pathogenesis treatment.
Language: Английский
Citations
39
Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12
Published: March 18, 2024
The global challenge posed by cancer, marked rising incidence and mortality rates, underscores the urgency for innovative therapeutic approaches. PI3K/Akt signaling pathway, frequently amplified in various cancers, is central regulating essential cellular processes. Its dysregulation, often stemming from genetic mutations, significantly contributes to cancer initiation, progression, resistance therapy. Concurrently, ferroptosis, a recently discovered form of regulated cell death characterized iron-dependent processes lipid reactive oxygen species buildup, holds implications diseases, including cancer. Exploring interplay between dysregulated pathway ferroptosis unveils potential insights into molecular mechanisms driving or inhibiting ferroptotic cells. Evidence suggests that may sensitize cells induction, offering promising strategy overcome drug resistance. This review aims provide comprehensive exploration this interplay, shedding light on disrupting enhance as an alternative route inducing improving treatment outcomes.
Language: Английский
Citations
28
Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)
Published: Aug. 16, 2024
Cuproptosis is a newly identified form of cell death induced by excessive copper (Cu) accumulation within cells. Mechanistically, cuproptosis results from Cu-induced aggregation dihydrolipoamide S-acetyltransferase, correlated with the mitochondrial tricarboxylic acid cycle and loss iron–sulfur cluster proteins, ultimately resulting in proteotoxic stress triggering death. Recently, has garnered significant interest tumor research due to its potential as crucial therapeutic strategy against cancer. In this review, we summarized cellular molecular mechanisms relationship other types Additionally, reviewed current drugs or strategies available induce cells, including Cu ionophores, small compounds, nanomedicine. Furthermore, targeted metabolism specific regulatory genes cancer therapy enhance sensitivity cuproptosis. Finally, discussed feasibility targeting overcome chemotherapy immunotherapy resistance suggested future directions. This study that could open new avenues for developing therapy.
Language: Английский
Citations
22
Gut Microbes, Journal Year: 2023, Volume and Issue: 15(2)
Published: Oct. 5, 2023
Ferroptosis is a distinctive form of iron-dependent necrotic cell death, characterized by excessive lipid peroxidation on cellular membranes and compromised antioxidant defenses. Multiple metabolic pathways, including iron metabolism, as well systems, contribute to the execution ferroptosis. The gut microbiota exerts regulatory effects ferroptosis through its microbial composition, biological functions, metabolites. Notably, most pathogenic bacteria tend promote ferroptosis, thereby inducing or exacerbating diseases, while probiotics have been shown protect against death. Given colonization in gut, an intimate association found between intestinal diseases microbiota. This review consolidates essential aspects ferroptotic processes, emphasizing key molecules delineating intricate interplay Moreover, this underscores potential utility modulation regulating for treatment diseases.
Language: Английский
Citations
25
Gastroenterology, Journal Year: 2024, Volume and Issue: 167(2), P. 231 - 249
Published: March 1, 2024
Language: Английский
Citations
13
International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 114034 - 114034
Published: Jan. 12, 2025
Language: Английский
Citations
2
Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(1)
Published: Jan. 6, 2025
Multiple sclerosis (MS) is a chronic autoimmune disorder marked by neuroinflammation, demyelination, and neuronal damage. Recent advancements highlight novel interaction between iron-dependent cell death, known as ferroptosis, gut microbiota, which may significantly influences the pathophysiology of MS. Ferroptosis, driven lipid peroxidation tightly linked to iron metabolism, pivotal contributor oxidative stress observed in Concurrently, affect systemic immunity neurological health, emerges an important regulator homeostasis inflammatory responses, thereby influencing ferroptotic pathways. This review investigates how microbiota dysbiosis ferroptosis impact MS, emphasizing their potential therapeutic targets. Through integrated examination mechanistic pathways clinical evidence, we discuss targeting these interactions could lead interventions that not only modulate disease progression but also offer personalized treatment strategies based on profiling. synthesis aims at deepening insights into microbial contributions implications setting stage for future research exploration.
Language: Английский
Citations
1
Archives of Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 761, P. 110172 - 110172
Published: Oct. 4, 2024
Language: Английский
Citations
8
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: May 27, 2024
Colorectal cancer (CRC) poses a significant global health challenge, ranking as the third most diagnosed and second leading cause of cancer-related deaths. Despite advancements in treatment, challenges such delayed diagnosis, multidrug resistance, limited therapeutic effectiveness persist, emphasizing need for innovative approaches. This review explores potential natural products, nutraceuticals, phytochemicals targeting ferroptosis-related regulators novel strategy CRC. Ferroptosis, form regulated cell death characterized by iron-dependent lethal lipid peroxide accumulation, holds substantial importance CRC progression therapy resistance. Natural known their diverse bioactive effects favorable safety profiles, emerge promising candidates to induce ferroptosis cells. Exploring amino acid, iron, metabolism regulators, oxidative stress reveals avenues inducing comprehensive provides insights into multifaceted products on proteins integral regulation, including GPX4, SLC7A11, ACSL4, NCOA4, HO-1. By elucidating intricate mechanisms through which modulate these proteins, this lays foundation
Language: Английский
Citations
7
Food and Chemical Toxicology, Journal Year: 2023, Volume and Issue: 178, P. 113925 - 113925
Published: July 4, 2023
Language: Английский
Citations
15