Life Sciences, Journal Year: 2024, Volume and Issue: 358, P. 123150 - 123150
Published: Oct. 30, 2024
Language: Английский
BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)
Published: Jan. 14, 2025
Head and neck squamous cell carcinoma (HNSCC), a highly invasive malignancy with poor prognosis, is one of the most common cancers globally. Circular RNAs (circRNAs) have become key regulators human malignancies, but further studies are necessary to fully understand their functions possible causes in HNSCC. CircCCT2 expression levels HNSCC tissues cells were measured via qPCR. was characterized by Sanger sequencing, qRT-PCR, RNase R & Actinomycin D treatment, nucleoplasmic separation FISH experiments. CCK-8 colony formation assays performed determine proliferation, Transwell used migration invasion. A xenograft tumor model study influence circCCT2 on vivo. Dual-luciferase gene reporter, RIP, western blotting, rescue experiments, explore target-binding relationships regulatory mechanisms. significantly upregulated cells. High associated advanced T stage, N clinical stage prognosis. Functionally, we verified that promotes development vitro Mechanistically, functioning as competitive endogenous RNA (ceRNA) or miRNA sponge, binds directly miR-146a-5p increases interleukin-1 receptor-associated kinase 1 (IRAK1) levels, which enhances malignant driving epithelial-mesenchymal transition (EMT). through miR-146a-5p/IRAK1 axis, revealing potential biomarker target for
Language: Английский
Citations
1
Extracellular Vesicle, Journal Year: 2025, Volume and Issue: 5, P. 100075 - 100075
Published: April 3, 2025
Language: Английский
Citations
1
Biomedicines, Journal Year: 2024, Volume and Issue: 12(4), P. 721 - 721
Published: March 25, 2024
MicroRNAs (miRNAs) are non-coding RNAs that act as master regulators of gene expression, fine-tuning the activity thousands genes in our cells, by modulating expression at post-transcriptional level [...]
Language: Английский
Citations
4
Cancer Science, Journal Year: 2024, Volume and Issue: 115(7), P. 2235 - 2253
Published: May 3, 2024
Triple-negative breast cancer (TNBC) has greater infiltration of M2-like macrophages (TAMs), which enhances cell invasion and leads to a poor prognosis. TNBC progression is mediated by both tumor cells the microenvironment (TME). Here we elucidate mechanism interaction between TAMs. In this study, confirmed that CD44v5 highly expressed in TNBC, drives metastasis promotes TAM polarization co-localizing with IL4Rα inhibiting its internalization degradation, thereby promoting activation STAT3/IL6 signaling axis. At same time, TAMs also facilitate secreting IL-4, IL-6, other cytokines, IL-4/IL-4R/STAT3/IL-6 axis plays role for responding Moreover, found above progress could be suppressed when domain was blocked. We demonstrated CD44v5/IL-4R/STAT3/IL-6 pathway key metastasis, inducing TAMs, metastasis. Collectively, suggest may promising target regulating TME as well treating TNBC.
Language: Английский
Citations
4
Bone, Journal Year: 2024, Volume and Issue: 190, P. 117323 - 117323
Published: Nov. 5, 2024
Language: Английский
Citations
4
Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111704 - 111704
Published: March 1, 2025
Language: Английский
Citations
0
npj Precision Oncology, Journal Year: 2025, Volume and Issue: 9(1)
Published: May 2, 2025
Glioblastoma is the most aggressive and lethal cancer of central nervous system, presenting substantial treatment challenges. The current standard treatment, which includes surgical resection followed by temozolomide radiation, offers limited success. While immunotherapies, such as immune checkpoint inhibitors, have proven effective in other cancers, they not demonstrated significant efficacy GBM. Emerging research highlights pivotal role tumor-associated macrophages (TAMs) supporting tumor growth, fostering resistance, shaping an immunosuppressive microenvironment. Preclinical studies show promising results for therapies targeting TAMs, suggesting potential overcoming these barriers. TAMs consist brain-resident microglia bone marrow-derived macrophages, both exhibiting diverse phenotypes functions within This review delves into origin, heterogeneity, functional roles GBM, underscoring their dual promotion suppression. It also summarizes recent progress TAM-targeted therapies, may, combination with treatments like immunotherapy, pave way more personalized strategies against this malignancy.
Language: Английский
Citations
0
Neuro-Oncology Advances, Journal Year: 2024, Volume and Issue: 6(1)
Published: Jan. 1, 2024
Standard treatment for newly diagnosed high-grade gliomas remains suboptimal. Preclinical data indicate that mesenchymal transition and radiation resistance in glioblastoma are driven by NF-κB microglia activation, which can be inhibited minocycline. We assessed the safety efficacy of minocycline combined with standard temozolomide gliomas.
Language: Английский
Citations
3
Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13
Published: Nov. 24, 2023
Glioblastoma (GB) tumors are one of the most insidious cancers which take over brain and defy therapy. Over time in response to treatment tumor cells microenvironment (TME) undergo many genetic/epigenetic driven changes their phenotypes this is reflected cellular contents within extracellular vesicles (EVs) they produce. With result that some EVs try subdue (friends brain), while others participate glioblastoma takeover (foes brain) a dynamic ever changing process. Monitoring these biofluids can inform decisions based on GB status guide therapeutic intervention. This review covers primarily recent research describing different cell types brain, as well cells, EV deluge. includes produced by manipulate transcriptome normal environment support growth (foes), responses restrict invasion, including traveling cervical lymph nodes present neo-antigens dendritic (DCs). In addition released into report living via cargo thus serving biomarkers. However, influence major factor immune suppression coercion join “band wagon”. Efforts being made deploy vehicles for drugs small inhibitory RNAs. Increasing knowledge about TME utilized track progression therapy even weaponize fight tumor.
Language: Английский
Citations
7
Animals, Journal Year: 2024, Volume and Issue: 14(2), P. 285 - 285
Published: Jan. 17, 2024
The ubiquitous Gram-negative bacterial pathogen Aeromonas veronii (A. veronii) can easily cause inflammatory reactions in aquatic organisms, resulting high mortality and huge economic losses. MicroRNAs (miRNAs) participate immune regulation have certain conserved properties. MiRNAs are involved the responses of a variety teleost fish infected with bacteria, whereas there is no related report silver carp (Hypophthalmichthys molitrix). Therefore, we identified expression profiles miRNA stimulated by A. LPS. Among them, quantity differentially expressed miRNAs (DEmiRNAs) obtained challenge group was 73 90 (LPS). GO enrichment analysis KEGG pathways shown that predicted target genes mainly associated lipid metabolism response carp. This indicates possibility play role regulating immune-related pathways. In addition, total eight DEmiRNAs validated accuracy sequencing result via quantitative real-time PCR (qRT-PCR). Finally, selected head kidney macrophage cells (HKCs) as model proved miR-30b-5p regulate HKCs. study lays foundation for exploring during pathogenic infection. it provides reference future development non-coding RNA antibacterial drugs.
Language: Английский
Citations
2